Protein Alignment Nlg2 and NLGN2

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_065846.1
• Gene: NLGN2 / 57555
• HGNCID: 14290
• Length: 835
• Species: Homo sapiens
• Alignment Length: 1047
• Identity: 285/1047 - (27%)
• Similarity: 420/1047 - (40%)
• Gaps: 320/1047 - (30%)

  Fly   185 VKTKYGLLRGIVVRS-------SPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPV 242
            |.|.||.:||  ||.       .|:|: |||:|||:||:|:.||.||..|::|..||:|....|.
Human    44 VNTAYGRVRG--VRRELNNEILGPVVQ-FLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPA 105

  Fly   243 CPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEP 307
            ||||:    :|....:.:|......|......::||||||||||:|||.|.....:..|:.|..|
Human   106 CPQNL----HGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNP 166

  Fly   308 KT-------KLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQ 365
            ..       |...::|:||.||...:||.:|||.|||:|||||.|:|:|||:.|||.| |.::|:
Human   167 PDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLST-GDQAAK 230

  Fly   366 GNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSAL 430
            ||:||:|.:..|.||.||:..|||||:.||:.|.|.||...|:|::|..:..|.|:.:..||:|:
Human   231 GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAI 295

  Fly   431 SPWAIQKNPLFVKRRVAEQTGCHGDMLYD--DLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDG 493
            |.|::...||...|.:|.:.||..:   |  :...|||.|...||:...|...|:.:.|.|.|||
Human   296 SSWSVNYQPLKYTRLLAAKVGCDRE---DSAEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDG 357

  Fly   494 TVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVE--SYLDLSAQDLEFGFNETR 556
            .|:            |....|:...| |:.|:   |::..:...|  .:::.||:. |.|.:.:.
Human   358 DVV------------PDDPEILMQQG-EFLNY---DMLIGVNQGEGLKFVEDSAES-EDGVSASA 405

  Fly   557 RDRILRTFVRNNFHYH-----LNEIFAVLKNEYTDWEKAIR-NPLSSRDATLQFLSDGHTASPLI 615
            .|..:..||.|.:.|.     |.|   .:|..||||  |.| |....|...|...:|....:|.:
Human   406 FDFTVSNFVDNLYGYPEGKDVLRE---TIKFMYTDW--ADRDNGEMRRKTLLALFTDHQWVAPAV 465

  Fly   616 KLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPM---SPLFPHNYTTQERQI 677
            ....:|:......||..|.|....|..|:.:.:..|:::|:..|:||   :.|||.|::..:..:
Human   466 ATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVML 530

  Fly   678 GRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQR 742
            ..:::.|.:||||||:|||       |.|.:.  ..:|         |.||..|.:
Human   531 SAVVMTYWTNFAKTGDPNQ-------PVPQDT--KFIH---------TKPNRFEEV--------- 568

  Fly   743 RSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQ 807
                                                       .|..::...:.|:.:|.|..::
Human   569 -------------------------------------------VWSKFNSKEKQYLHIGLKPRVR 590

  Fly   808 SHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVR-PQLQTK-----PAED 866
            .:||.:|::.||.|:|.||   |:               :.:|:....| |...|:     ||..
Human   591 DNYRANKVAFWLELVPHLH---NL---------------HTELFTTTTRLPPYATRWPPRPPAGA 637

  Fly   867 DNIIIMQRSRTTTPPPPSKNPSTNATQALNPLGTGTPTTTECGIDGAMSVSELTTTQSPKDNRTG 931
            ..        |..||||       ||....|.....|...:               :.|.|:|
Human   638 PG--------TRRPPPP-------ATLPPEPEPEPGPRAYD---------------RFPGDSR-- 670

  Fly   932 IVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQRE 996
                                             .|:|.|..|||||..||.||:|.||.:|::|:
Human   671 ---------------------------------DYSTELSVTVAVGASLLFLNILAFAALYYKRD 702

  Fly   997 KRARDAKTKEELQEGDNSKNSSILKLNALMGGGGACGSG-PGDIADAYTLSGSVVDSKGGVGVVF 1060
            :|          ||         |:...|...||: ||| ||        .|.::.:.|.
Human   703 RR----------QE---------LRCRRLSPPGGS-GSGVPG--------GGPLLPAAGR----- 734

  Fly  1061 GEYSCYDEKTKQLKEEKLLVELPPSSSTGQTSLMIDNWGACSTSTLDLLKTKPGDPIEMVTYSAL 1125
                                ||||....  .||.:...|...           .||.|.:..:..
Human   735 --------------------ELPPEEEL--VSLQLKRGGGVG-----------ADPAEALRPACP 766

  Fly  1126 PSVMESTSAMSSKRGSFVDTTLQFNSPQQFDYAVQSSDQMSFKAIEDAVKAAAGHDSEITRDDDI 1190
            |                 |.||...                 :|.:|....|.|..:.:......
Human   767 P-----------------DYTLALR-----------------RAPDDVPLLAPGALTLLPSGLGP 797

  Fly  1191 PEPPPPP 1197
            |.|||||
Human   798 PPPPPPP 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	196/570 (34%)
NLGN2	NP_065846.1	COesterase	42..601	CDD:395084	205/659 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..668		14/74 (19%)
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	678..698		12/19 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..835		6/15 (40%)