DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg2 and NLGN4X

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	XP_005274621.1	Gene:	NLGN4X / 57502	HGNCID:	14287	Length:	836	Species:	Homo sapiens

Alignment Length:	929	Identity:	277/929 - (29%)
Similarity:	408/929 - (43%)	Gaps:	259/929 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 CALL---VLLLLTSL------------WPDCCECLHGGSNTVKTKYGLLRGIVVRSSPL------ 202
            |.:|   |||.||:|            :|           .|.|.||.:||:   .:||
Human    18 CVMLNSNVLLWLTALAIKFTLIDSQAQYP-----------VVNTNYGKIRGL---RTPLPNEILG 68

  Fly   203 -VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLE--VPRAR 264
             ||.:||:||||||.|..||.||..||:|..:|:..:|:.||||::     ...:||.  :|...
Human    69 PVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHL-----DERSLLHDMLPIWF 128

  Fly   265 LAQLRRLLPLLKNQSEDCLYLNIYVPYET-RRQRRNTDDTT----GEPK------TKLSTVVFIH 318
            .|.|..|:..:::|:|||||||||||.|. ...::|.||.|    ||.:      :|...:|:||
Human   129 TANLDTLMTYVQDQNEDCLYLNIYVPTEDGANTKKNADDITSNDRGEDEDIHDQNSKKPVMVYIH 193

  Fly   319 GESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKEN 383
            |.||...:||..|||.||::|||||:|||:||||.|||.| |.::|:||:||:|.:..|.|::||
Human   194 GGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLST-GDQAAKGNYGLLDQIQALRWIEEN 257

  Fly   384 LPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAE 448
            :.||||||:.:|:.|.|.||...::|.:|..:..|.|:.::.||:|||.||:...|....|.:|:
Human   258 VGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILAD 322

  Fly   449 QTGCHGDML-YDDLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGS 512
            :.||  :|| ..|:..|||.|:..||:...:....:.:.|.|.:||.||            |...
Human   323 KVGC--NMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVI------------PDDP 373

  Fly   513 AIVSTSGIEYANFPKRDLIFCLTSVE--SYLDLSAQDLEFGFNETRRDRILRTFVRNNFHY---- 571
            .|:...| |:.|:   |::..:...|  .::| ...|.|.|......|..:..||.|.:.|
Human   374 QILMEQG-EFLNY---DIMLGVNQGEGLKFVD-GIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGK 433

  Fly   572 -HLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKH 635
             .|.|   .:|..||||... .||.:.|...:...:|....:|.:....:|:..|...||..|.|
Human   434 DTLRE---TIKFMYTDWADK-ENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYH 494

  Fly   636 KTIEEEYPQRSGSVRGEDVPFWLGLPM---SPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQS 697
            ....|..|..:.|..|::||:..|:||   :.||..|::..:..:..:::.|.:||||||:|||
Human   495 HCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQ- 558

  Fly   698 TAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSND 762
                  |.|.:.  ..:|         |.||                              |..:
Human   559 ------PVPQDT--KFIH---------TKPN------------------------------RFEE 576

  Fly   763 AAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHR 827
            .|                      |..|:..:|||:.:|.|..::.|||..|::.||.|:|.||
Human   577 VA----------------------WSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLH- 618

  Fly   828 HFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPSTNAT 892
              |:|:                                     |.|...|||..||....|.
Human   619 --NLNE-------------------------------------IFQYVSTTTKVPPPDMTSF--- 641

  Fly   893 QALNPLGTGT------PTTTECGIDGAMSVSELTTTQSPK----DNRTG----IVRVETQKDLAT 943
                |.||..      |||....|         |...:||    .::||    .|.:||::|
Human   642 ----PYGTRRSPAKIWPTTKRPAI---------TPANNPKHSKDPHKTGPEDTTVLIETKRD--- 690

  Fly   944 ASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQREKRARDAKTKEEL 1008
                                  |:|.|..|:|||..||.||:|.||.:|::::||..:...:...
Human   691 ----------------------YSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSP 733

  Fly  1009 QEGDNS-----KNSSILKL 1022
            |....:     :|..|:.|
Human   734 QRNTTNDIAHIQNEEIMSL 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	198/560 (35%)
NLGN4X	XP_005274621.1	COesterase	42..610	CDD:278561	216/680 (32%)
NLGN4X	XP_005274621.1	Aes	<179..>286	CDD:223730	53/107 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I954
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1598
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8600
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.960