Protein Alignment Nlg2 and nlgn4xa

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: XP_021330915.1
• Gene: nlgn4xa / 561122
• ZFINID: ZDB-GENE-100309-2
• Length: 844
• Species: Danio rerio
• Alignment Length: 907
• Identity: 275/907 - (30%)
• Similarity: 402/907 - (44%)
• Gaps: 253/907 - (27%)

  Fly   155 HPEA-CALLVLLLLTSLW---------PDCCECLHGGSNTVKTKYGLLRGIVVRSSPL------- 202
            ||.| ..|...::|.:.|         |           .|.|.||.|||:   .:||
Zfish    16 HPLATLRLFTWIVLAAAWLAITWAQQHP-----------IVTTNYGKLRGL---KTPLPNEILGP 66

  Fly   203 VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLE--VPRARL 265
            ||.:||||||.||.|..||.||..|.:|..:|:|.:|:|||||.:.     ...||.  :|....
Zfish    67 VEQYLGIPYALPPTGERRFQPPEPPMSWPGIRNATQFAPVCPQFLE-----DRFLLNDMLPVWFT 126

  Fly   266 AQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTT---GEPKT------KLSTVVFIHGES 321
            |.|..::..:::|||||||||||||.|.....:..|.|.   ||.|.      ....:|:|||.|
Zfish   127 ANLDTVVTYVQDQSEDCLYLNIYVPTEDVGANKGDDFTNNEGGENKDIHDENGLRPVMVYIHGGS 191

  Fly   322 YDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPA 386
            |...:||..|||.||::|||||||:|:|||:.|||.| |.::|:||:||:|.:..|.|:|||:.|
Zfish   192 YMEGTGNMIDGSILASYGNVIVVTLNYRLGVLGFLST-GDQAAKGNYGLLDQIQALRWIKENIQA 255

  Fly   387 FGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTG 451
            |.|||:.:|:.|.|.||...::|.:|..:.||.|:.::.||:|||.||:...|....|.:||:.|
Zfish   256 FKGDPKRVTIFGSGAGASCVSLLTLSHYSEDLFQKAIIQSGTALSSWAVNYQPAKYTRILAEKVG 320

  Fly   452 CHGDMLYD-DLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIV 515
            |  :||.. ||..||:.|:..||:...:...::.:.|.|.:||.||            |....|:
Zfish   321 C--NMLDSIDLVECLQNKNYKELIEQYITQAKYHIAFGPVIDGDVI------------PDDPQIL 371

  Fly   516 STSGIEYANFPKRDLIFCLTS----------VESYLDLSAQDLEFGFNETRRDRILRTFVRNNFH 570
            ...| |:.|:   |::..:..          |:|...:||.|.:|..::         ||.:.:.
Zfish   372 MEQG-EFLNY---DIMLGVNQGEGFKFVDGIVDSEDGVSANDFDFAVSD---------FVDHLYG 423

  Fly   571 Y-----HLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYF 630
            |     .|.|   .:|..||||... .||.:.|...:...:|....:|.:....:|:..|...||
Zfish   424 YPEGKDTLRE---TIKFMYTDWADK-ENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYF 484

  Fly   631 LHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPM---SPLFPHNYTTQERQIGRLMLRYLSNFAKTG 692
            ..|.|....|..|..|.|..|::||:..|:||   :.||..|::..:..:..:::.|.:||||||
Zfish   485 YAFYHHCQSEMKPSWSDSAHGDEVPYVFGIPMLGPTDLFNCNFSKNDVMLSAVVMTYWTNFAKTG 549

  Fly   693 NPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRR 757
            :|||       |.|.:.  ..:|         |.||
Zfish   550 DPNQ-------PVPQDT--KFIH---------TKPN----------------------------- 567

  Fly   758 LRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLI 822
             |..:.|                      |..|:..:|||:.:|.|..::.|||..|::.||.|:
Zfish   568 -RFEEVA----------------------WSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELV 609

  Fly   823 PQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTK-PAEDDNIIIMQRSRTTTPPPPSKN 886
            |.||   |||                :|::.|   ...|| |.:|           |||.|.:|.
Zfish   610 PHLH---NIN----------------ELFQYV---STTTKIPPQD-----------TTPFPYTKR 641

  Fly   887 PSTNATQALNPLGTGTPTTT-ECGIDGAMSVSELTTTQSPKDNRTG-------IVRVETQKDLAT 943
                       ||...|:|| ..|:..|       .|:...|.|.|       .|.:||::|
Zfish   642 -----------LGKTWPSTTRHPGVPPA-------NTKQTTDQRKGNDLSDDSAVVIETKRD--- 685

  Fly   944 ASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQREKRARDAKTK 1005
                                  |:|.|..|:|||..||.||:|.||.:|::::||..::..:
Zfish   686 ----------------------YSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHESNRR 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	202/583 (35%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:395084	217/682 (32%)