DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg2 and nlgn4xa

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	XP_021330915.1	Gene:	nlgn4xa / 561122	ZFINID:	ZDB-GENE-100309-2	Length:	844	Species:	Danio rerio

Alignment Length:	907	Identity:	275/907 - (30%)
Similarity:	402/907 - (44%)	Gaps:	253/907 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 HPEA-CALLVLLLLTSLW---------PDCCECLHGGSNTVKTKYGLLRGIVVRSSPL------- 202
            ||.| ..|...::|.:.|         |           .|.|.||.|||:   .:||
Zfish    16 HPLATLRLFTWIVLAAAWLAITWAQQHP-----------IVTTNYGKLRGL---KTPLPNEILGP 66

  Fly   203 VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLE--VPRARL 265
            ||.:||||||.||.|..||.||..|.:|..:|:|.:|:|||||.:.     ...||.  :|....
Zfish    67 VEQYLGIPYALPPTGERRFQPPEPPMSWPGIRNATQFAPVCPQFLE-----DRFLLNDMLPVWFT 126

  Fly   266 AQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTT---GEPKT------KLSTVVFIHGES 321
            |.|..::..:::|||||||||||||.|.....:..|.|.   ||.|.      ....:|:|||.|
Zfish   127 ANLDTVVTYVQDQSEDCLYLNIYVPTEDVGANKGDDFTNNEGGENKDIHDENGLRPVMVYIHGGS 191

  Fly   322 YDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPA 386
            |...:||..|||.||::|||||||:|:|||:.|||.| |.::|:||:||:|.:..|.|:|||:.|
Zfish   192 YMEGTGNMIDGSILASYGNVIVVTLNYRLGVLGFLST-GDQAAKGNYGLLDQIQALRWIKENIQA 255

  Fly   387 FGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTG 451
            |.|||:.:|:.|.|.||...::|.:|..:.||.|:.::.||:|||.||:...|....|.:||:.|
Zfish   256 FKGDPKRVTIFGSGAGASCVSLLTLSHYSEDLFQKAIIQSGTALSSWAVNYQPAKYTRILAEKVG 320

  Fly   452 CHGDMLYD-DLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIV 515
            |  :||.. ||..||:.|:..||:...:...::.:.|.|.:||.||            |....|:
Zfish   321 C--NMLDSIDLVECLQNKNYKELIEQYITQAKYHIAFGPVIDGDVI------------PDDPQIL 371

  Fly   516 STSGIEYANFPKRDLIFCLTS----------VESYLDLSAQDLEFGFNETRRDRILRTFVRNNFH 570
            ...| |:.|:   |::..:..          |:|...:||.|.:|..::         ||.:.:.
Zfish   372 MEQG-EFLNY---DIMLGVNQGEGFKFVDGIVDSEDGVSANDFDFAVSD---------FVDHLYG 423

  Fly   571 Y-----HLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYF 630
            |     .|.|   .:|..||||... .||.:.|...:...:|....:|.:....:|:..|...||
Zfish   424 YPEGKDTLRE---TIKFMYTDWADK-ENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYF 484

  Fly   631 LHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPM---SPLFPHNYTTQERQIGRLMLRYLSNFAKTG 692
            ..|.|....|..|..|.|..|::||:..|:||   :.||..|::..:..:..:::.|.:||||||
Zfish   485 YAFYHHCQSEMKPSWSDSAHGDEVPYVFGIPMLGPTDLFNCNFSKNDVMLSAVVMTYWTNFAKTG 549

  Fly   693 NPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRR 757
            :|||       |.|.:.  ..:|         |.||
Zfish   550 DPNQ-------PVPQDT--KFIH---------TKPN----------------------------- 567

  Fly   758 LRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLI 822
             |..:.|                      |..|:..:|||:.:|.|..::.|||..|::.||.|:
Zfish   568 -RFEEVA----------------------WSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELV 609

  Fly   823 PQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTK-PAEDDNIIIMQRSRTTTPPPPSKN 886
            |.||   |||                :|::.|   ...|| |.:|           |||.|.:|.
Zfish   610 PHLH---NIN----------------ELFQYV---STTTKIPPQD-----------TTPFPYTKR 641

  Fly   887 PSTNATQALNPLGTGTPTTT-ECGIDGAMSVSELTTTQSPKDNRTG-------IVRVETQKDLAT 943
                       ||...|:|| ..|:..|       .|:...|.|.|       .|.:||::|
Zfish   642 -----------LGKTWPSTTRHPGVPPA-------NTKQTTDQRKGNDLSDDSAVVIETKRD--- 685

  Fly   944 ASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQREKRARDAKTK 1005
                                  |:|.|..|:|||..||.||:|.||.:|::::||..::..:
Zfish   686 ----------------------YSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHESNRR 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	199/566 (35%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:306613	217/682 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I889
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6461
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.910