Protein Alignment Nlg2 and nlgn2a

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: XP_009301340.1
• Gene: nlgn2a / 556158
• ZFINID: ZDB-GENE-090918-2
• Length: 828
• Species: Danio rerio
• Alignment Length: 923
• Identity: 270/923 - (29%)
• Similarity: 406/923 - (43%)
• Gaps: 229/923 - (24%)

  Fly   140 RRHLHYPGHSAVQPGHPEACALLVLLLLTSLWPDCCEC--LHGGSN--TVKTKYGLLRGIVVRSS 200
            :|.|.|..:|.|.  |      .:.|...:||.....|  :..|:.  ||.|.||.||||....:
Zfish     8 KRDLGYAHNSEVT--H------TIALFWLALWITLASCQRIDPGTKYPTVTTNYGKLRGIKKELN 64

  Fly   201 -----PLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNG--PEALL 258
                 | ||.:||:|||:.|:|..||.||..|.:|:.||:|.:|:||||||:    :|  ||.:|
Zfish    65 NEILGP-VEQYLGVPYATAPIGDRRFQPPEAPGSWQEVRNATQFAPVCPQNV----HGVLPEIML 124

  Fly   259 EVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTT-GEP-------KTKLSTVV 315
              |......|......::||||||||||:|||.|.....:..|::| ..|       :.|...::
Zfish   125 --PVWFTDSLDVAATYIQNQSEDCLYLNVYVPTEDGPLTKKHDESTLNRPRDEDIRDRRKKPVML 187

  Fly   316 FIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWL 380
            ||||.||...:||.:|.|.|||:|||||||:|:|||:.|||.| |.:||:||:||:|.:..|.||
Zfish   188 FIHGGSYMEGTGNMFDASVLAAYGNVIVVTMNYRLGVLGFLST-GDQSAKGNYGLLDQIQALRWL 251

  Fly   381 KENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRR 445
            .||:..|||||:.||:.|.|.||...|:|::|..:..|.||.:..||||:|.|:|...||...:.
Zfish   252 NENIGHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQRAIAQSGSAISSWSISYQPLKYTKI 316

  Fly   446 VAEQTGC-HGDMLYDDLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLP 509
            :|.:.|| :|:..  ||..|||.|:..||:...:...|:.:.|.|.:||.|:            |
Zfish   317 LARKVGCTYGETA--DLVDCLRRKNFRELVDQDIQPARYHIAFGPVMDGDVV------------P 367

  Fly   510 LGSAIVSTSGIEYANFPKRDLIFCLTSVE--SYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYH 572
            ....|:...| |:.|:   ||:..:...|  .::|....:.|.|.:....|..:..||.|.:.|.
Zfish   368 DDPEILMQQG-EFLNY---DLLIGVNQGEGLKFVDDGGTESEEGISAAAFDYTISNFVDNLYGYP 428

  Fly   573 LNE--IFAVLKNEYTDWEKAIR-NPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFK 634
            ..:  :...:|..||||  |.| |....|...|...:|....:|.|....:|:......||..|.
Zfish   429 KGKDILRETIKFMYTDW--ADRDNGEMRRKTLLALFTDHQWVAPAIATAKLHADYQSPVYFYTFY 491

  Fly   635 HKTIEEEYPQRSGSVRGEDVPFWLGLPM---SPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQ 696
            |....|..|:.:.:..|:::|:..|:||   :.|||.|::..:..:..:::.|.:||||||:||
Zfish   492 HHCQTETRPEWADAAHGDEIPYVFGVPMIGATDLFPCNFSKNDIMLSAVVMTYWTNFAKTGDPN- 555

  Fly   697 STAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSN 761
                  ||.|.:.  ..:|         |.||..|.:
Zfish   556 ------LPVPQDT--KFIH---------TKPNRFEEV---------------------------- 575

  Fly   762 DAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLH 826
                                    .|..::..::.|:.:|.|..|:.:||.:|::.||.|:|.||
Zfish   576 ------------------------IWTKFNSKDKQYLHIGLKPRIRDNYRANKVAFWLELVPHLH 616

  Fly   827 RHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPSTNA 891
               |::::                                    :...:.|..||..::.|...
Zfish   617 ---NLHEE------------------------------------VFSTATTRLPPGTARTPHWK- 641

  Fly   892 TQALNPLGTGTPTTTECGIDGAMSVSELTTTQSPK------DNRTGIVRVETQKDLATASTGIIG 950
                   |.| |.||...|....|..:..:::.|:      |.|
Zfish   642 -------GQG-PRTTRHPIPTFPSELDPDSSEQPRFPPFPSDTR--------------------- 677

  Fly   951 NLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQREKRARDAKTKEELQEG---- 1011
                          .|:|.|..|||||..||.||:|.||.:|::|:||....:.:...|.|
Zfish   678 --------------DYSTELSVTVAVGASLLFLNILAFAALYYKRDKRHEMRRHRLSPQRGVAAN 728

  Fly  1012 --DNSKNSSILKL 1022
              .:|:...|:.|
Zfish   729 DLAHSQEEEIMSL 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	204/572 (36%)
nlgn2a	XP_009301340.1	COesterase	47..608	CDD:395084	214/658 (33%)