DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and NLGN3

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_851820.1	Gene:	NLGN3 / 54413	HGNCID:	14289	Length:	848	Species:	Homo sapiens

Alignment Length:	908	Identity:	267/908 - (29%)
Similarity:	400/908 - (44%)	Gaps:	226/908 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 TVKTKYGLLRGIVVRSSPL-------VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSP 241
            ||.|.:|.|||..|   ||       |:.:||:|||:||:|..||:||..|.:|..:|:|..|.|
Human    43 TVNTHFGKLRGARV---PLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPP 104

  Fly   242 VCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYE-------------- 292
            ||||||....  ||.:|  |....|.|..:...::..:|||||||:|||.|
Human   105 VCPQNIHTAV--PEVML--PVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPN 165

  Fly   293 ----------TRRQRRNTDDTTGEPKTKL------STVVFIHGESYDWNSGNPYDGSELAAHGNV 341
                      .::|..:..|..|:....:      ..:|:|||.||...:||..|||.||::|||
Human   166 KKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNV 230

  Fly   342 IVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLA 406
            ||:|:|:|:|:.|||.| |.::|:||:||:|.:..|.|:.||:..|||||:.||:.|.|.||...
Human   231 IVITLNYRVGVLGFLST-GDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCV 294

  Fly   407 NILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYD--DLAPCLRTKS 469
            ::|.:|..:..|.||.::.||||||.||:...|:.....:|::.||:   :.|  |:..|||.||
Human   295 SLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCN---VLDTVDMVDCLRQKS 356

  Fly   470 VAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCL 534
            ..||:...:...|:.|.|.|.:||.||            |....|:...| |:.|:   |::..:
Human   357 AKELVEQDIQPARYHVAFGPVIDGDVI------------PDDPEILMEQG-EFLNY---DIMLGV 405

  Fly   535 TSVE--SYLDLSAQDLEFGFNETRRDRILRTFVRNNFHY-----HLNEIFAVLKNEYTDWEKAIR 592
            ...|  .::: ...|.|.|.:.|..|..:..||.|.:.|     .|.|   .:|..||||  |.|
Human   406 NQGEGLKFVE-GVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDW--ADR 464

  Fly   593 -NPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPF 656
             ||.:.|...:...:|.....|.:....:|:..|...||..|.|.......|..|.:..|::||:
Human   465 DNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPY 529

  Fly   657 WLGLPM---SPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQK 718
            ..|:||   :.|||.|::..:..:..:::.|.:||||||:||:       |.|.:
Human   530 VFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNK-------PVPQD---------- 577

  Fly   719 KRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDE 783
                                     :..:|.|.:      |..:.|
Human   578 -------------------------TKFIHTKAN------RFEEVA------------------- 592

  Fly   784 LPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNR 848
               |..|:..:|||:.:|.|..::.|||..|::.|.:|:|.|   :|::|  |.|:
Human   593 ---WSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHL---YNLHD--MFHY--------- 640

  Fly   849 DLYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPSTNATQALNPLGTGTPTTTECGIDGA 913
                                     .|.||..|||....|::.|:  .|.|. |.:|....|..|
Human   641 -------------------------TSTTTKVPPPDTTHSSHITR--RPNGK-TWSTKRPAISPA 677

  Fly   914 MSVSELTTTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGC 978
            .| :|........|...|.:.||..:|                         |:|.|..|:|||.
Human   678 YS-NENAQGSWNGDQDAGPLLVENPRD-------------------------YSTELSVTIAVGA 716

  Fly   979 FLLILNVLIFAGIYHQREKRARDAKTKEELQEGDNSKNSSIL---KLNALMGG--GGACGSGP 1036
            .||.||||.||.:|::::||.::...:...|.|..:......   :|.||..|  ...|.:||
Human   717 SLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGAGAPELGAAPEEELAALQLGPTHHECEAGP 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	196/577 (34%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	211/683 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..195		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..694		15/52 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I954
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1598
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8600
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.960