Protein Alignment Nlg2 and Ces2h

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_001037723.1
• Gene: Ces2h / 498940
• RGDID: 1560889
• Length: 558
• Species: Rattus norvegicus
• Alignment Length: 725
• Identity: 178/725 - (24%)
• Similarity: 282/725 - (38%)
• Gaps: 227/725 - (31%)

  Fly   158 ACALLVLLLL---TSLWPDCCECLHGGSNTVKTKY-GLLRGIVVRSSPL---VEAFLGIPYASPP 215
            ||.||:||.:   .||.|            ::|.: |.:.|.::....|   |.:|||||:|.||
  Rat    14 ACGLLLLLQVQGQDSLSP------------IRTTHTGQILGSLIHMKGLDVGVHSFLGIPFAKPP 66

  Fly   216 VGSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSE 280
            :|.|||.||..|..|..||.......:|.|:|        ..:.:...:|  |:..|||:. .||
  Rat    67 IGPLRFAPPEAPEPWSGVRDGTSHPAMCLQDI--------TAMNMQAFKL--LKLTLPLIP-MSE 120

  Fly   281 DCLYLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVT 345
            ||||||||.|.....            .:.|..:|:|||.:......:.||||.|||..||:|||
  Rat   121 DCLYLNIYTPNHAHE------------GSNLPVMVWIHGGALVIGMASLYDGSMLAAMENVVVVT 173

  Fly   346 INFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILV 410
            |.:|||:.||..| |.:.|:||:|.:|.||.|||:::|:..|||:|..:|:.|...|....:..|
  Rat   174 IQYRLGVLGFFST-GDQHARGNWGYLDQVAALHWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHV 237

  Fly   411 VSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAELLA 475
            |||::..|....::.||.||....|..:...|.|.||..:||. .:....|..|||.||..|:::
  Rat   238 VSPMSRGLFHGAIMESGVALMSSLISVSSDVVYRTVANLSGCE-QVDSKALVNCLRGKSEEEIMS 301

  Fly   476 VK---------VD------HPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYA-N 524
            :.         ||      ||:.|:..|.|          :|:.|        |:..:..||. .
  Rat   302 INKAFRIISGIVDGIFLPRHPKELLASADF----------HPIPS--------IIGVNNDEYGWI 348

  Fly   525 FPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKN------- 582
            .|.     .:|:.:|              :.:.||.:              :.|:|:.
  Rat   349 IPS-----SMTTTDS--------------KKKMDRQM--------------VQAILQKRVAQMMW 380

  Fly   583 --EYTD--WEKAIRNPLSSRDATLQF---LSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKT--I 638
              |::|  .|:.:.:....:...:||   :.|.....|.:::.:... .....||..|:|:.  .
  Rat   381 PPEFSDLLLEEYMGDSEDPQFLQVQFKEMMEDFTFVIPALQVAHFQR-SNAPVYFYEFQHRPSFF 444

  Fly   639 EEEYPQRSGSVRGEDV-----PFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQST 698
            ::..|....:..|:::     .||.|..:      :.|.:|..:.|.|::|.:|||:.||||
  Rat   445 KDSKPPHVKADHGDEILFIFRSFWGGTQV------DLTEEEELLSRRMMKYWANFARQGNPN--- 500

  Fly   699 AKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDA 763
                                                                             
  Rat   501 ----------------------------------------------------------------- 500

  Fly   764 AFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRH 828
                             .:.||:|..:|...| |::|..:..:....:..:|..|...:|:..|
  Rat   501 -----------------SEGLPYWPVFDHDEQ-YLQLDTQPAVGRALKAKRLQFWTKTLPEKIR- 546

  Fly   829 FNINDQSMRH 838
             .:.|...||
  Rat   547 -ELKDTEDRH 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	155/587 (26%)
Ces2h	NP_001037723.1	COesterase	30..537	CDD:395084	164/687 (24%)