DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and alpha-Est4

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_524266.1	Gene:	alpha-Est4 / 40906	FlyBaseID:	FBgn0015572	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	136/577 - (23%)
Similarity:	231/577 - (40%)	Gaps:	151/577 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 VKTKYGLLRGIVVRS--SPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNI 247
            |:|.:|.:|||:::|  .....||.|||||.||:|:|||..|.....|..:|...:
  Fly    12 VQTTHGKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSK--------- 67

  Fly   248 PIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEPKTKLS 312
                         |.::..|:..|...::. |||||||||.|           ....|:|   :.
  Fly    68 -------------PLSKCLQVSTLTKEVEG-SEDCLYLNISV-----------KTLNGDP---MP 104

  Fly   313 TVVFIHGESY-DWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKE-SAQGNFGLMDLVA 375
            .:|:|||.:: ..:|.....|.:.....||:.::|..|||..|||.....: ...||.||.|::.
  Fly   105 VMVYIHGGAFKGGDSSRRAWGPDYFMKENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVIL 169

  Fly   376 GLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPL 440
            .|.|::.|...|.|||:.||:.|:.:|::...:|:.||.:..|..|.:|::|     ::::.|.|
  Fly   170 ALRWIRANAANFNGDPERITIFGHSSGSMTVQLLLASPQSEGLFHRAILLAG-----FSMELNRL 229

  Fly   441 -FVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVKVDHPRFLVG----------------FA 488
             .::.|:|:..|..||.:         ...|.|.| :|.| |..:|.                |.
  Fly   230 PQMEYRLAKHLGYEGDNV---------DSQVLEFL-LKAD-PALIVSADFFTPLEKRQGHNMPFK 283

  Fly   489 PFVDGTVISPG----ANPLG------STTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVESYLDL 543
            |.:: :..:|.    |.|:.      |..:|:.....|..|:...:|.|.:        .|:|.
  Fly   284 PSIE-SYSTPNAVLLAEPIDLQRTTWSNRIPIILGANSGEGMSIFSFVKMN--------PSWLK- 338

  Fly   544 SAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDG 608
                 ||..|.   :|:|...:||.                  .:...|..|.  .|.:....:.
  Fly   339 -----EFQCNP---ERVLPWTLRNR------------------CDPGQRRQLG--QALIHHFCEA 375

  Fly   609 H-------TASPLIKL---GYMHS--------LRGGRA--YFLHFKHKTIEEEY-------PQRS 646
            |       ..:.|::|   |::|:        |..|:|  |...|...:.:..:       .::.
  Fly   376 HGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAPTYLYRFDFDSPDFNFYRIRFMGKEQR 440

  Fly   647 GSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVL 703
            |....:::.:...||.:  |..:.:..|....|.::.....||.|.:||....||::
  Fly   441 GVGHVDELGYIFKLPAT--FKLDKSRPEFTAIRRLVAMFVQFAATSDPNAPLTKSLV 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	136/577 (24%)
alpha-Est4	NP_524266.1	Abhydrolase	7..529	CDD:304388	136/577 (24%)
alpha-Est4	NP_524266.1	Aes	<104..>219	CDD:223730	36/114 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810