DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg2 and alpha-Est7

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	140/561 - (24%)
Similarity:	220/561 - (39%)	Gaps:	136/561 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 TKYGLLRGIVVRSSPLVE----AFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNI 247
            |:||.:|||  :...|.:    :|.|||||.||||.|||..|..|..|:.||.       |.|
  Fly    37 TEYGQVRGI--KRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD-------CSQ-- 90

  Fly   248 PIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEPKTKLS 312
                         |:.:..|::.:...::. ||||||||:|           |::.  :|.....
  Fly    91 -------------PKDKAVQVQFVFDKVEG-SEDCLYLNVY-----------TNNV--KPDKARP 128

  Fly   313 TVVFIHGESYDWNSGN-PYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKE-SAQGNFGLMDLVA 375
            .:|:|||..:.....| .:.|.:.....:|::|||.:|||..||:.....| :..||.||.|.|.
  Fly   129 VMVWIHGGGFIIGEANREWYGPDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVL 193

  Fly   376 GLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWA----IQ 436
            .|.|:|.|..:|||||..||:.|...|....:.::::.....|..|.:|.||||:.|||    |.
  Fly   194 ALKWIKNNCASFGGDPNCITVFGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDIT 258

  Fly   437 KNPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVKVD-------HPRFLVGFAPFVDGT 494
            .||.    |:|:..|..|:....|:...|:.....:|:.|:.:       ..:.:..|.|.::
  Fly   259 HNPY----RIAKLVGYKGEDNDKDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLE-- 317

  Fly   495 VISPGANP--------------LGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVESYLDLSA 545
               |.:.|              ..|.::|:.....|..|:.:.  |:..|   :..|...||...
  Fly   318 ---PFSTPECVISKPPKEMMKTAWSNSIPMFIGNTSYEGLLWV--PEVKL---MPQVLQQLDAGT 374

  Fly   546 QDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAV--LKNEYTDWEKAIRN-----PLSSRDATLQ 603
            ..:.                        .|:.|.  .|.:...|...||:     ..|:.|..:.
  Fly   375 PFIP------------------------KELLATEPSKEKLDSWSAQIRDVHRTGSESTPDNYMD 415

  Fly   604 FLSDGHTASPLIKLGYMHS----LRGGRAYFLHFKHKTIEEEYPQR--------SGSVRGEDVPF 656
            ..|..:...|.:::  :||    ..|...||..:...:.|..:|.|        .|....:|:.:
  Fly   416 LCSIYYFVFPALRV--VHSRHAYAAGAPVYFYRYDFDSEELIFPYRIMRLGRGVKGVSHADDLSY 478

  Fly   657 WLGLPMSPLFP---HNYTTQERQIGRLMLRYLSNFAKTGNP 694
            .....::...|   ..|...||.:|     ..:.||.||||
  Fly   479 QFSSLLARRLPKESREYRNIERTVG-----IWTQFAATGNP 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	140/561 (25%)
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	138/559 (25%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	37/117 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810