DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and alpha-Est10

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	147/570 - (25%)
Similarity:	229/570 - (40%)	Gaps:	119/570 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 NTVKTKYGLLRGIVVRSSPL----VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVC 243
            :.:|||.|.:||  |:.:.:    ..:|..||:|.||||.|||..|.....|.  :..|..||.
  Fly    49 SVIKTKSGPVRG--VKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWD--QELDCTSPA- 108

  Fly   244 PQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEPK 308
                           :.|.......|:..     .||||||||:||           .|.  :|.
  Fly   109 ---------------DKPLQTHMFFRKYA-----GSEDCLYLNVYV-----------KDL--QPD 140

  Fly   309 TKLSTVVFIHGESYDWN--SGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKE-SAQGNFGL 370
            .....:|:|:|..|...  |.:.| ..:.....:|::||:.:|||..|||.....: :..||.||
  Fly   141 KLRPVMVWIYGGGYQVGEASRDMY-SPDFFMSKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGL 204

  Fly   371 MDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWA- 434
            .|.:..|.|:::|:.|||||..:|||.|...|....:.|.:||....||.:.:::|||.|.||.
  Fly   205 KDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQ 269

  Fly   435 -IQKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRT-------KSVAELLAVKVDHPRFLVGFAPFV 491
             .:.|..:   |:|::.|..||.....:...||:       |:.|.:|:....|.|.|..|.|.|
  Fly   270 PPRNNWAY---RLAQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVV 331

  Fly   492 -----DGTVISPGANPL----GSTTLPLGSAIVSTSG-IEYANFPKRDLIFCLTSVESYLDLSAQ 546
                 :.||::...:.|    .|..:|:.....|..| :.|....:|..  .|..|.:..:|...
  Fly   332 EPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPA--TLDEVGNCKNLLPS 394

  Fly   547 DLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDAT--LQFLSDGH 609
            ||  |.|       |...:|.|:...|.:.:      :.|      .|.:..:..  |:..|...
  Fly   395 DL--GLN-------LDPKLRENYGLQLKKAY------FGD------EPCNQANMMKFLELCSYRE 438

  Fly   610 TASPLIKLGYMHSLRGGRA--YFLHFKHKT-------IEEEYPQRSGSVRGEDVPFWL------- 658
            ...|:.:.. ::.:|...|  |...|.|.:       |.....|..|...|:|:.:..
  Fly   439 FWHPIYRAA-LNRVRQSSAPTYLYRFDHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQ 502

  Fly   659 GLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNE 708
            ..|.||         |.::...|:...::||..|:||..:.||:...|.|
  Fly   503 SAPDSP---------EHKVITGMVDVWTSFAAHGDPNCESIKSLKFAPIE 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	147/570 (26%)
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	145/567 (26%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	49/163 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810