Protein Alignment Nlg2 and Ces3a

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_941074.1
• Gene: Ces3a / 382053
• MGIID: 102773
• Length: 571
• Species: Mus musculus
• Alignment Length: 588
• Identity: 175/588 - (29%)
• Similarity: 257/588 - (43%)
• Gaps: 106/588 - (18%)

  Fly   158 ACALLVLLLLTSLWPDCCECLHGGSNTVKTKYGLLRG--IVVRSSP-LVEAFLGIPYASPPVGSL 219
            || ||::...|.:.|...:      ..|.|..|.:||  :.|:.:. :|..|||||:|..|:|.|
Mouse    19 AC-LLLIFPTTVIGPKVTQ------PEVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPLGPL 76

  Fly   220 RFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLY 284
            ||..|:.|..|:.||.|....|:|.|::....|.        |..|.:..::.|:    |||||.
Mouse    77 RFSAPLPPQPWEGVRDASINPPMCLQDVERMSNS--------RFTLNEKMKIFPI----SEDCLT 129

  Fly   285 LNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFR 349
            ||||.|         |:.|.|:   |...:|:|||.|....|...:|||.|||:|:|:|||:.:|
Mouse   130 LNIYSP---------TEITAGD---KRPVMVWIHGGSLLVGSSTSHDGSALAAYGDVVVVTVQYR 182

  Fly   350 LGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPV 414
            |||||||.||.|. ..||.|.:|:||.|.|::.|:..|||||..:|:.|...|.::.:.|::||:
Mouse   183 LGIFGFLSTGDKH-MPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPM 246

  Fly   415 ASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVKVD 479
            ::.|..|.:..||..:|......|.....:..|....| |.....:|..||..|...:|:..|..
Mouse   247 SAGLFHRAISQSGVVISKILEDLNAWSEAQNFANSVAC-GSASPAELVQCLLQKEGKDLITKKNV 310

  Fly   480 HPRFLV--GFAPFVDGTVISPGANP---LGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVES 539
            :..:.|  .|.|          ..|   |.:...|....::..:..|:.        :.|....:
Mouse   311 NISYTVNDSFFP----------QRPQKLLANKQFPTVPYLLGVTNHEFG--------WLLLKFWN 357

  Fly   540 YLD----LSAQDLEFGFNETRRDRILRTFVRNNFHYHL-NEIFAVLKNEYTD---WEKAIRNPLS 596
            .||    ||.:||    .|..|..:.        |..| .||...:.:||.|   .|.|.|..|.
Mouse   358 ILDKMEHLSQEDL----LENSRPLLA--------HMQLPPEIMPTVIDEYLDNGSDESATRYALQ 410

  Fly   597 S--RDATL--------QFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRG 651
            .  .|.||        ::|.|  ...|:....:.|:    .:.|..||...::.::...:..|.|
Mouse   411 ELLGDITLVIPTLIFSKYLQD--AGCPVFLYEFQHT----PSSFAKFKPAWVKADHSSENAFVFG 469

  Fly   652 EDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNP-----NEVLE 711
            .  ||.........|| ..|.:|:|:...|:...|.||:|||||   .|.:.|.|     .:.||
Mouse   470 G--PFLTDESSLLAFP-EATEEEKQLSLTMMAQWSQFARTGNPN---GKGLPPWPQLNQLEQYLE 528

  Fly   712 TAL 714
            ..|
Mouse   529 IGL 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	169/564 (30%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:395084	169/570 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571