DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg2 and Jhedup

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	152/558 - (27%)
Similarity:	236/558 - (42%)	Gaps:	133/558 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 GLLRGIVV--RSSPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPN 252
            |.:||.::  ..|...|||:|||:|.||||.||...|:....|:.|..|......|
  Fly    28 GCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSC--------- 83

  Fly   253 GPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFI 317
                   :.|:..|:...|:.:     |||||||:|      |.:...:|       ||..:|:|
  Fly    84 -------IQRSYFAKEWGLMGV-----EDCLYLNVY------RPKNRAED-------KLPVMVYI 123

  Fly   318 HGESYDWNSGNPY-DGSELAAHGN-VIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWL 380
            ||..:...|.:|. .|.|.....| |::||:|:|||.||||.| |.|...||||..|....|.|:
  Fly   124 HGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLST-GDEHMPGNFGFKDQRLALQWI 187

  Fly   381 KENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSA-LSPWAIQKNPLFVKR 444
            ::::..|||||:.:|:||:..|.:.|::.::||.:..|.|.::.::|:. ||...|.|:||...|
  Fly   188 QKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQAR 252

  Fly   445 RVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLP 509
            |:       |..|..|.|..|.::.:||.|. .|...:.||.    ||...:......|  ||||
  Fly   253 RL-------GKELAIDQAESLSSQDLAEALR-NVCPKKLLVS----VDSLKVWDNMPHL--TTLP 303

  Fly   510 LGSAIVSTSGIEYANFPKRDLIFCLTSVESY-----------LDLSAQDLEFGFNETRRDRILRT 563
            :..|            |..|.......::::           |.||::..|...      .|:|.
  Fly   304 VLEA------------PSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAGEGSL------FIMRA 350

  Fly   564 FVRNNFHYHLNEIF----AVLKN--EYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHS 622
            |:........||.|    |:|.|  |.|. .:.:...|.:.|    |..|......::||..:
  Fly   351 FINPKLRAEFNENFLEHMALLLNLPEGTP-VQMVSEILDAYD----FKGDSLNNDTMLKLAEI-- 408

  Fly   623 LRGGRAYFLHFKHKTIE--------EEYP------------------------QRSGSVRGEDVP 655
              .|...|.:..::||.        ||.|                        ...|:|..:|..
  Fly   409 --SGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGL 471

  Fly   656 FWLGLPMS-PLFPHNYTTQERQIGRLMLRYLSNFAKTG 692
            ..:.:|:| ..||.:  :::.::.:.|...:::|||||
  Fly   472 HTIRIPVSFDDFPKD--SEDAKVIQRMSSLMTDFAKTG 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	152/558 (27%)
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	151/555 (27%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	43/117 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810