Protein Alignment Nlg2 and Nlg3

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: XP_061500330.1
• Gene: Nlg3 / 3290865
• VectorBaseID: AGAMI1_000316
• Length: 952
• Species: Anopheles gambiae
• Alignment Length: 1082
• Identity: 348/1082 - (32%)
• Similarity: 494/1082 - (45%)
• Gaps: 252/1082 - (23%)

  Fly   123 SATSAASAAPAGATSPRRRHLHYPGHSAVQPGHPEACALLVLLLLTSLWPDCCECLHGGSNTVKT 187
            |.:|::|::.....||....   ||.:::....       .|...||            |..|.|
Mosquito    26 SGSSSSSSSSGSGNSPSNGG---PGSNSMDENE-------TLKKSTS------------SRIVHT 68

  Fly   188 KYGLLRGIVV----RSSPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIP 248
            |||.:.|.:.    |....||||.|:||||||||:||||||:|.:.|..|:.||||||||||.:|
Mosquito    69 KYGAVSGTIEHLDGRHLDPVEAFRGVPYASPPVGNLRFMPPVTGALWSGVKKADRFSPVCPQRLP 133

  Fly   249 IPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEPKTKLST 313
            ...|...||..:||.||..||||||.|:||||||||||||||  |:...|.:..|     :|.:.
Mosquito   134 DIYNETAALERMPRGRLEYLRRLLPYLRNQSEDCLYLNIYVP--TQAGSRESSST-----SKYAV 191

  Fly   314 VVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGK--ESAQGNFGLMDLVAG 376
            |||:|||||:||||||||||.||::|.::|||||:||||.|||.....  ..|..|:||||::|.
Mosquito   192 VVFVHGESYEWNSGNPYDGSVLASYGQILVVTINYRLGILGFLNANVDRFSKAPANYGLMDIIAA 256

  Fly   377 LHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASD--LIQRTVLVSGSALSPWAIQKNP 439
            |||::||:.||||||:|:||.|:||||...:.|:.|....:  |..|.:::|||.|:||::...|
Mosquito   257 LHWIQENIEAFGGDPKSVTLAGHGTGAACVHFLIASAAVPEGLLFHRAIMMSGSGLAPWSLVGEP 321

  Fly   440 LFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISPG----- 499
            ......|:....|..|:.:..|..|||.|.:.::|:..|..|.|...|.|.|||.||..|
Mosquito   322 AKFAAYVSHHVNCSPDLPHQLLLKCLRDKPLEDILSTSVRAPDFGNAFGPSVDGVVIDTGEIQQM 386

  Fly   500 ---------ANPLGS-------TTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQDL 548
                     .||..:       .||...:||:... :......|.||:..:|..|:|...:::|:
Mosquito   387 DGTHYSDYSGNPAATKPSAHIHNTLNTINAILLRK-LAINKLSKYDLLVGVTRAEAYFAFNSEDV 450

  Fly   549 EFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASP 613
            ::|....||.:||:.:||:.:.:|||||.|.:.|||||||:.:::|::.||.||:.|||....:|
Mosquito   451 QYGIEADRRAKILKNYVRSTYSFHLNEILATIVNEYTDWERPVQHPINIRDETLEALSDARIVAP 515

  Fly   614 LIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPMSPLFPH---NYTTQER 675
            .::...:||.....::...|.::|...::|||.|.:.|||:|:..|.|:...|.|   |||..|.
Mosquito   516 AVQTADLHSADHRNSFLYVFDYQTKFGDFPQRQGCIHGEDLPYLFGAPLVGGFNHFTRNYTKSEI 580

  Fly   676 QIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYN 740
            .:...::.|.|||.:||            ||||.||
Mosquito   581 ALSEAVMIYWSNFIRTG------------NPNEQLE----------------------------- 604

  Fly   741 QRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKAN 805
                      ..::|.|.|..:..                      |..|:.|::.|:.|..|..
Mosquito   605 ----------NDHVRDRTRFKNIE----------------------WTPYESVHKKYLNLDTKPK 637

  Fly   806 IQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTKPAEDDNII 870
            :::|||.|:||.||||:|.||:..| :|....||:.:.|...:......|:|.
Mosquito   638 LKNHYRAHRLSFWLNLVPDLHKPGN-DDVPSGHHELESDDEEQPAALPTVKPL------------ 689

  Fly   871 IMQRSRTTTPPPPSKNPST---NAT-------QALNPLGTGTPTTTECGIDGAMSVSELTTTQSP 925
                      .||.::|:|   |.|       ..||....|..........|...|..:|...|.
Mosquito   690 ----------NPPQRDPATIGSNYTLFTTQVFSLLNFSSYGILPNGSRHYPGTRPVHPVTAESSE 744

  Fly   926 KDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAG 990
            ..:..|        ..|....|..|.:...:..|   |.:|:|||..|:|:||.|||||||||||
Mosquito   745 GGDDDG--------GAAGGGAGGAGGMSSSQEDG---FAAYSTALSVTIAIGCSLLILNVLIFAG 798

  Fly   991 IYHQREKRARDAKTKEELQEGDNSKNSSILKLNALMGGGGACGSGPGDIADAYTLSGSVVDSKGG 1055
            :|:||:|                      .:||...|||...| ||                 ||
Mosquito   799 VYYQRDK----------------------TRLNEPRGGGPGMG-GP-----------------GG 823

  Fly  1056 VGVVFGEYSCYDEKTKQLKE------------EKLLV--ELPPSSSTGQTSLMIDNWGACSTSTL 1106
            .|.:         :||:..|            |.|.:  :..||:..|.....:.:.........
Mosquito   824 HGTL---------QTKKRNENGQMPNNICGELESLTIHAKADPSTILGHHHPALQHHQMPPPEFA 879

  Fly  1107 DL----------LKTKPGDPIEMVTYSALPSVMESTSAMSSK 1138
            ||          ||:.|||...|:...||..:..:...::.|
Mosquito   880 DLPQRAPPPPKHLKSVPGDGGGMLPAHALQLIGSNCGTLTKK 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	237/578 (41%)
Nlg3	XP_061500330.1	None