Protein Alignment Nlg2 and CES4A

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 761
• Identity: 196/761 - (25%)
• Similarity: 305/761 - (40%)
• Gaps: 251/761 - (32%)

  Fly   159 CALLVLLLL--TSLWPDCCECLHGGSNTVKTKYGLLRG--IVVRSSPLVEAFLGIPYASPPVGSL 219
            |..|.|.|:  |:|     ..||.....|.||||.|:|  :.|..:| ::.|||:|::.||:|.|
Human    29 CWSLTLCLMAQTAL-----GALHTKRPQVVTKYGTLQGKQMHVGKTP-IQVFLGVPFSRPPLGIL 87

  Fly   220 RFMPPITPSTWKTVRSADRFSP-----------------------------VCPQNIPIPPNGPE 255
            ||.||..|..||.:|.|..:.|                             :.||  |:...|..
Human    88 RFAPPEPPEPWKGIRDATTYPPGWSLALSPGWSAVARSRLTATSASRVQASLLPQ--PLSIWGYR 150

  Fly   256 ALLE----------VPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEPKTK 310
            .|.|          ..|.|...||        .||||||||:|.|..          ..|:|  :
Human   151 CLQESWGQLASMYVSTRERYKWLR--------FSEDCLYLNVYAPAR----------APGDP--Q 195

  Fly   311 LSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGK---ESAQGNFGLMD 372
            |..:|:..|.::...:.:.|:||:|||...|::|.:..||||||||:..|:   ..|:||:||:|
Human   196 LPVMVWFPGGAFIVGAASSYEGSDLAAREKVVLVFLQHRLGIFGFLRWRGRTDDSHARGNWGLLD 260

  Fly   373 LVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQK 437
            .:|.|.|::||:.||||||.::||.|...||:..:.|::||:||.|..|.:..||:||....|..
Human   261 QMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAISQSGTALFRLFITS 325

  Fly   438 NPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVKVDHPRFLV------------GFAPF 490
            |||.|.::||...||:.:.. ..|..|||..|..:::.|. :..|||.            ..:|.
Human   326 NPLKVAKKVAHLAGCNHNST-QILVNCLRALSGTKVMRVS-NKMRFLQLNFQRDPEEIIWSMSPV 388

  Fly   491 VDGTVISPGANPLGSTTLPLGSAI---VSTSGIEY-------ANFP-------KRDLIFCLTSVE 538
            |||.||..  :||...|....|::   :..:.:|:       ..||       |..:...|.|..
Human   389 VDGVVIPD--DPLVLLTQGKVSSVPYLLGVNNLEFNWLLPYIMKFPLNRQAMRKETITKMLWSTR 451

  Fly   539 SYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSS--RDAT 601
            :.|:::.:.:.....|                 :|:.:     ||: || |.:||.:..  :|||
Human   452 TLLNITKEQVPLVVEE-----------------YLDNV-----NEH-DW-KMLRNRMMDIVQDAT 492

  Fly   602 LQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKT---IEEEYPQRSGSVRGEDV------PFW 657
            ..:.:        ::..:.|...|...|...|:|..   |.:  |:..|:..|:::      ||.
Human   493 FVYAT--------LQTAHYHRDAGLPVYLYEFEHHARGIIVK--PRTDGADHGDEMYFLFGGPFA 547

  Fly   658 LGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRST 722
            .||.|.         :|:.:...|::|.:|||:|||||
Human   548 TGLSMG---------KEKALSLQMMKYWANFARTGNPN--------------------------- 576

  Fly   723 SLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFW 787
                                                                     ||: ||.|
Human   577 ---------------------------------------------------------DGN-LPCW 583

  Fly   788 DAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLI----PQLHRHF 829
            ..|: .::.|::|.....:....:..|::.|::|.    |:..|.|
Human   584 PRYN-KDEKYLQLDFTTRVGMKLKEKKMAFWMSLYQSQRPEKQRQF 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	174/630 (28%)
CES4A	XP_011521323.1	COesterase	50..613	CDD:395084	183/718 (25%)