DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and CES4A

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	XP_011521323.1	Gene:	CES4A / 283848	HGNCID:	26741	Length:	628	Species:	Homo sapiens

Alignment Length:	761	Identity:	196/761 - (25%)
Similarity:	305/761 - (40%)	Gaps:	251/761 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 CALLVLLLL--TSLWPDCCECLHGGSNTVKTKYGLLRG--IVVRSSPLVEAFLGIPYASPPVGSL 219
            |..|.|.|:  |:|     ..||.....|.||||.|:|  :.|..:| ::.|||:|::.||:|.|
Human    29 CWSLTLCLMAQTAL-----GALHTKRPQVVTKYGTLQGKQMHVGKTP-IQVFLGVPFSRPPLGIL 87

  Fly   220 RFMPPITPSTWKTVRSADRFSP-----------------------------VCPQNIPIPPNGPE 255
            ||.||..|..||.:|.|..:.|                             :.||  |:...|..
Human    88 RFAPPEPPEPWKGIRDATTYPPGWSLALSPGWSAVARSRLTATSASRVQASLLPQ--PLSIWGYR 150

  Fly   256 ALLE----------VPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEPKTK 310
            .|.|          ..|.|...||        .||||||||:|.|..          ..|:|  :
Human   151 CLQESWGQLASMYVSTRERYKWLR--------FSEDCLYLNVYAPAR----------APGDP--Q 195

  Fly   311 LSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGK---ESAQGNFGLMD 372
            |..:|:..|.::...:.:.|:||:|||...|::|.:..||||||||:..|:   ..|:||:||:|
Human   196 LPVMVWFPGGAFIVGAASSYEGSDLAAREKVVLVFLQHRLGIFGFLRWRGRTDDSHARGNWGLLD 260

  Fly   373 LVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQK 437
            .:|.|.|::||:.||||||.::||.|...||:..:.|::||:||.|..|.:..||:||....|..
Human   261 QMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAISQSGTALFRLFITS 325

  Fly   438 NPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVKVDHPRFLV------------GFAPF 490
            |||.|.::||...||:.:.. ..|..|||..|..:::.|. :..|||.            ..:|.
Human   326 NPLKVAKKVAHLAGCNHNST-QILVNCLRALSGTKVMRVS-NKMRFLQLNFQRDPEEIIWSMSPV 388

  Fly   491 VDGTVISPGANPLGSTTLPLGSAI---VSTSGIEY-------ANFP-------KRDLIFCLTSVE 538
            |||.||..  :||...|....|::   :..:.:|:       ..||       |..:...|.|..
Human   389 VDGVVIPD--DPLVLLTQGKVSSVPYLLGVNNLEFNWLLPYIMKFPLNRQAMRKETITKMLWSTR 451

  Fly   539 SYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSS--RDAT 601
            :.|:::.:.:.....|                 :|:.:     ||: || |.:||.:..  :|||
Human   452 TLLNITKEQVPLVVEE-----------------YLDNV-----NEH-DW-KMLRNRMMDIVQDAT 492

  Fly   602 LQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKT---IEEEYPQRSGSVRGEDV------PFW 657
            ..:.:        ::..:.|...|...|...|:|..   |.:  |:..|:..|:::      ||.
Human   493 FVYAT--------LQTAHYHRDAGLPVYLYEFEHHARGIIVK--PRTDGADHGDEMYFLFGGPFA 547

  Fly   658 LGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRST 722
            .||.|.         :|:.:...|::|.:|||:|||||
Human   548 TGLSMG---------KEKALSLQMMKYWANFARTGNPN--------------------------- 576

  Fly   723 SLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFW 787
                                                                     ||: ||.|
Human   577 ---------------------------------------------------------DGN-LPCW 583

  Fly   788 DAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLI----PQLHRHF 829
            ..|: .::.|::|.....:....:..|::.|::|.    |:..|.|
Human   584 PRYN-KDEKYLQLDFTTRVGMKLKEKKMAFWMSLYQSQRPEKQRQF 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	174/613 (28%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	184/722 (25%)
CES4A	XP_011521323.1	Aes	<184..>291	CDD:223730	44/118 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810