DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and Tg

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_112250.2	Gene:	Tg / 24826	RGDID:	3848	Length:	2768	Species:	Rattus norvegicus

Alignment Length:	647	Identity:	172/647 - (26%)
Similarity:	266/647 - (41%)	Gaps:	164/647 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 LHGGSNTVKTKYGLLRGIVVRSSPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPV 242
            |.|||..||         |..:...|..|||:|||:||:...||..| ....|.....|.:....
  Rat  2210 LQGGSQVVK---------VGTAWKQVYQFLGVPYAAPPLAENRFQAP-EVLNWTGSWDATKLRSS 2264

  Fly   243 CPQ---NIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTT 304
            |.|   ..|.||               |:          ||||||||::||...
  Rat  2265 CWQPGTRTPTPP---------------QI----------SEDCLYLNVFVPENL----------- 2293

  Fly   305 GEPKTKLSTVVFIHGESYDWNSGNP--YDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGN 367
               .:..|.:||.|.......||..  .|||.|||.||:||||.|:|||:||||.:|..|.| ||
  Rat  2294 ---VSNASVLVFFHNTVEMEGSGGQLNIDGSILAAVGNLIVVTANYRLGVFGFLSSGSDEVA-GN 2354

  Fly   368 FGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANI--LVVSPVASDLIQRTVLVSGSAL 430
            :||:|.||.|.|::.::.|||||||.:||.....||.:|:|  |:..|....|.::.:|:.||||
  Rat  2355 WGLLDQVAALTWVQTHIGAFGGDPQRVTLAADRGGADVASIHLLITRPTRLQLFRKALLMGGSAL 2419

  Fly   431 SPWAIQKNPLFVKRR---VAEQTGCHGDMLYDDLAPCLRTK-----SVAELLAVKVDHPRFLVGF 487
            ||.|| .:|...:::   :|::.||....: .::..|.|.|     :.|:...:.|..|....|
  Rat  2420 SPAAI-ISPDRAQQQAAALAKEVGCPNSSV-QEVVSCFRQKPANILNEAQTKLLAVSGPFHYWG- 2481

  Fly   488 APFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQDLEFGF 552
             |.|||..:....:......||:                |.||:...:..:..::.:....:|..
  Rat  2482 -PVVDGQYLRELPSRRLKRPLPV----------------KVDLLIGGSQDDGLINRAKAVKQFEE 2529

  Fly   553 NETRRD--------------------RILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSS 597
            ::.|.:                    |||...:   ::|.|..    ..::|..:.:|:.|  ::
  Rat  2530 SQGRTNSKTAFYQALQNSLGGEDSDARILAAAI---WYYSLEH----STDDYASFSRALEN--AT 2585

  Fly   598 RDATLQFLSDGHTASPLIKLGYMHSLR-GGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLP 661
            ||..:        ..|::.:..:.:.| .|..:..|     :.|.|...|..:.. ||.:..|||
  Rat  2586 RDYFI--------ICPIVNMASLWARRTRGNVFMYH-----VPESYGHGSLELLA-DVQYAFGLP 2636

  Fly   662 MSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPN------QSTAKSVLPNPNEVLETALHQQKKR 720
            ....:...::.:|:.:...:::|.|||.::||||      |..|:...|.|:.|........|:.
  Rat  2637 FYSAYQGYFSMEEQSLSLKVMQYFSNFIRSGNPNYPHEFSQKAAEFATPWPDFVPGAGGESYKEL 2701

  Fly   721 STSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDV-GSYDG 781
            |..|  ||                          |:.|:..|.:|....|.:.:|. |:.||
  Rat  2702 SAQL--PN--------------------------RQGLKKADCSFWSKYIQTLKDADGAKDG 2735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	155/571 (27%)
Tg	NP_112250.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	164..249	CDD:294100
		TY	301..359	CDD:238114
		TY	<613..658	CDD:238114
		TY	661..724	CDD:238114
		TY	730..>776	CDD:294100
		TY	<893..922	CDD:238114
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1455..1468
		GCC2_GCC3	1464..1509	CDD:285001
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1469..1485
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1486..1502
		TY	1519..1566	CDD:214561
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1602..1722
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1723..1891
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1892..1994
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1995..2127
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	2128..2185
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		172/647 (27%)
		COesterase	2198..2719	CDD:278561	166/629 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2731..2768		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910