Protein Alignment Nlg2 and Ces2a

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_653344.1
• Gene: Ces2a / 246252
• RGDID: 708353
• Length: 558
• Species: Rattus norvegicus
• Alignment Length: 704
• Identity: 177/704 - (25%)
• Similarity: 268/704 - (38%)
• Gaps: 199/704 - (28%)

  Fly   153 PG--HPEACALLVLLLLTSLWPDCCECLHG---GSNTVKTKYGLLRGIVVR---SSPLVEAFLGI 209
            ||  :..||.||:||          :.:||   .|....|..|.:||..|.   :...:..||||
  Rat     7 PGWLYVVACGLLLLL----------QHVHGQDSASPIRNTHTGQVRGSFVHVKDTKSGIHTFLGI 61

  Fly   210 PYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNG-PEALLEVPRARLAQLRRLLP 273
            |:|.||||.|||.||..|..|..||.|.....:|.|...:..:| .|..|.|....:
  Rat    62 PFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTDIMNLDGIKEMKLTVHPTPM-------- 118

  Fly   274 LLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAH 338
                 ||||||||||.|...|.            .:.|..:|:|||......|.:..|.|.|||.
  Rat   119 -----SEDCLYLNIYTPAHARE------------GSNLPVMVWIHGGGLVLGSASMNDASTLAAT 166

  Fly   339 GNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGA 403
            ..:::|:|.:|||:.||..| |.::|:||:|.:|.||.|.|:::|:..|||:...:|:.|...|.
  Rat   167 EEIVIVSIQYRLGVLGFFST-GDQNARGNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGG 230

  Fly   404 VLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHG-DMLYDDLAPCLRT 467
            ...:..||||::..|....::.||.||.|..|......|.:.||..:||.. |.  :.|..|||.
  Rat   231 TSVSSHVVSPMSKGLFHGAIMQSGVALLPDLISDKSEVVYKTVANLSGCEAPDS--EALIRCLRA 293

  Fly   468 KSVAELLAVK---------VD------HPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVST 517
            ||..|:||:.         ||      ||:.|:....|      .|..:.:|..|...|..|...
  Rat   294 KSKQEILAINQVFKMIPGVVDGKFLPKHPQELLASGDF------HPVPSIIGINTDECGWGIPVF 352

  Fly   518 SGIEY--ANFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVL 580
            .|:::  ....:..|...|.|..:.:.|..:.::                             ::
  Rat   353 LGLDHIIKKITRETLPTVLKSTAAQMMLPPECID-----------------------------LI 388

  Fly   581 KNEYT-DWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKH--KTIEEEY 642
            ..||. |.|    ||.:.::.....|.|.....|.:::.:....: ...||..|:|  ..|::..
  Rat   389 MEEYMGDTE----NPETLQEQFRHMLGDFMFVIPALQVAHFQRSQ-APVYFYEFQHLPSFIKQVR 448

  Fly   643 PQRSGSVRGEDVPFWLGLPMSPLFPHNY--TTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPN 705
            |....:..|:|:.|..|   |.|:...:  |.:|..:.|.:::|.:|||:|||||
  Rat   449 PSHVKADHGDDILFVFG---SYLWGMTFDLTEEEELLKRRVMKYWANFARTGNPN---------- 500

  Fly   706 PNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGI 770
                                                                             
  Rat   501 ----------------------------------------------------------------- 500

  Fly   771 SSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQ 824
                      |::||.|...|...| |::|..:..:....:..:|..|...:||
  Rat   501 ----------GEDLPHWPVLDHDEQ-YLQLNTQPAVGRALKARRLQFWTKTLPQ 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	155/573 (27%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	164/663 (25%)