DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg2 and Nlgn3

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_766520.2	Gene:	Nlgn3 / 245537	MGIID:	2444609	Length:	825	Species:	Mus musculus

Alignment Length:	888	Identity:	267/888 - (30%)
Similarity:	400/888 - (45%)	Gaps:	206/888 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 TVKTKYGLLRGIVVRSSPL-------VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSP 241
            ||.|.:|.|||..|   ||       |:.:||:|||:||:|..||:||..|.:|..:|:|..|.|
Mouse    40 TVNTHFGKLRGARV---PLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPP 101

  Fly   242 VCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYE----TRRQRRNTDD 302
            ||||||....  ||.:|  |....|.|..:...::..:|||||||:|||.|    .::|..:..|
Mouse   102 VCPQNIHTAV--PEVML--PVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLAD 162

  Fly   303 TTGEPKTKL------STVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGK 361
            ..|:....:      ..:|:|||.||...:||..|||.||::|||||:|:|:|:|:.|||.| |.
Mouse   163 NDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYRVGVLGFLST-GD 226

  Fly   362 ESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVS 426
            ::|:||:||:|.:..|.|:.||:..|||||:.||:.|.|.||...::|.:|..:..|.||.::.|
Mouse   227 QAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQS 291

  Fly   427 GSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYD--DLAPCLRTKSVAELLAVKVDHPRFLVGFAP 489
            |||||.||:...|:.....:|::.||:   :.|  |:..|||.||..||:...:...|:.|.|.|
Mouse   292 GSALSSWAVNYQPVKYTSLLADKVGCN---VLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGP 353

  Fly   490 FVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVE--SYLDLSAQDLEFGF 552
            .:||.||            |....|:...| |:.|:   |::..:...|  .::: ...|.|.|.
Mouse   354 VIDGDVI------------PDDPEILMEQG-EFLNY---DIMLGVNQGEGLKFVE-GVVDPEDGV 401

  Fly   553 NETRRDRILRTFVRNNFHY-----HLNEIFAVLKNEYTDWEKAIR-NPLSSRDATLQFLSDGHTA 611
            :.|..|..:..||.|.:.|     .|.|   .:|..||||  |.| ||.:.|...:...:|....
Mouse   402 SGTDFDYSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDW--ADRDNPETRRKTLVALFTDHQWV 461

  Fly   612 SPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPM---SPLFPHNYTTQ 673
            .|.:....:|:..|...||..|.|.......|..|.:..|::||:..|:||   :.|||.|::..
Mouse   462 EPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKN 526

  Fly   674 ERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVL 738
            :..:..:::.|.:||||||:||:       |.|.:
Mouse   527 DVMLSAVVMTYWTNFAKTGDPNK-------PVPQD------------------------------ 554

  Fly   739 YNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNK 803
                 :..:|.|.:      |..:.|                      |..|:..:|||:.:|.|
Mouse   555 -----TKFIHTKAN------RFEEVA----------------------WSKYNPRDQLYLHIGLK 586

  Fly   804 ANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTKPAEDDN 868
            ..::.|||..|::.|.:|:|.|   :|::|  |.|:
Mouse   587 PRVRDHYRATKVAFWKHLVPHL---YNLHD--MFHY----------------------------- 617

  Fly   869 IIIMQRSRTTTPPPPSKNPSTNATQALNPLGTGTPTTTECGIDGAMSVSELTTTQSPKDNRTGIV 933
                 .|.||..|||....|::.|:  .|.|. |.:|....|..|.| :|........|...|.:
Mouse   618 -----TSTTTKVPPPDTTHSSHITR--RPNGK-TWSTKRPAISPAYS-NENAPGSWNGDQDAGPL 673

  Fly   934 RVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQREKR 998
            .||..:|                         |:|.|..|:|||..||.||||.||.:|::::||
Mouse   674 LVENPRD-------------------------YSTELSVTIAVGASLLFLNVLAFAALYYRKDKR 713

  Fly   999 ARDAKTKEELQEGDNSKNSSIL---KLNALMGG--GGACGSGP 1036
            .::...:...|.|..:......   :|.||..|  ...|.:||
Mouse   714 RQEPLRQPSPQRGTGAPELGTAPEEELAALQLGPTHHECEAGP 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	196/557 (35%)
Nlgn3	NP_766520.2	COesterase	39..601	CDD:365897	211/663 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..172		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..668		14/49 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	360	1.000	Domainoid score	I955
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8833
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.910