DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg2 and Cel

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus

Alignment Length:	805	Identity:	198/805 - (24%)
Similarity:	303/805 - (37%)	Gaps:	261/805 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 LLVLLL-LTSLWPDCCECLHGGSNTVKTKYGLLRGIVVRSSPL----VEAFLGIPYASPPVGSLR 220
            |.||.| ||......|....|   .|.|:.|.:.|:..:.|.|    |:.|.|||:|
  Rat     4 LEVLFLGLTCCLAAACAAKLG---AVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFA-------- 57

  Fly   221 FMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQ-----SE 280
                    |.||:.:        ||..|    |.:..|:....:    :|.|.....|     .|
  Rat    58 --------TAKTLEN--------PQRHP----GWQGTLKATDFK----KRCLQATITQDDTYGQE 98

  Fly   281 DCLYLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNP--------YDGSELAA 337
            |||||||:|| :.|:|..:          .|..:|:|:|.::...||..        |||.|:|.
  Rat    99 DCLYLNIWVP-QGRKQVSH----------DLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIAT 152

  Fly   338 HGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTG 402
            .|||||||.|:|:|..|||.| |..:..|||||.|....:.|:|.|:.||||||.:||:.|...|
  Rat   153 RGNVIVVTFNYRVGPLGFLST-GDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAG 216

  Fly   403 AVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRT 467
            |...::..:||....||:|.:..||.||||||||:||||..:.:|::.||          |...|
  Rat   217 AASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGC----------PTEDT 271

  Fly   468 KSVAELLAVKVDHPRFL------------------VGFAPFVDGTVISPGANPLGSTTLPLGSAI 514
            ..:|..|  |:..||.|                  :.|.|.|||..|..  :|:..
  Rat   272 AKMAGCL--KITDPRALTLAYRLPLKSQEYPIVHYLAFIPVVDGDFIPD--DPINL--------- 323

  Fly   515 VSTSGIEYANFPKRDLIFCLTSVESYL----DLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNE 575
                   |.|....|.:..:..::.:|    |:.|.|      :.::|      |.....|.|..
  Rat   324 -------YDNAADIDYLAGINDMDGHLFATVDVPAID------KAKQD------VTEEDFYRLVS 369

  Fly   576 IFAVLK---------NEYTD-W-----EKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRG 625
            ...|.|         :.||: |     ::.::..:.:.:..:.||.....|   :.....|: :.
  Rat   370 GHTVAKGLKGTQATFDIYTESWAQDPSQENMKKTVVAFETDILFLIPTEMA---LAQHRAHA-KS 430

  Fly   626 GRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAK 690
            .:.|...|.|.:....||:..|:...:|:.:..|.|.:.  |..|..|:|.:.:.|:.|.:||||
  Rat   431 AKTYSYLFSHPSRMPIYPKWMGADHADDLQYVFGKPFAT--PLGYRAQDRTVSKAMIAYWTNFAK 493

  Fly   691 TGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIR 755
            :|:||...:    |.|                  ||
  Rat   494 SGDPNMGNS----PVP------------------TH----------------------------- 507

  Fly   756 RRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNK---ANIQSHYRGHKLSM 817
                                           |..|...|..|:::..|   .:::.|.|...|..
  Rat   508 -------------------------------WYPYTTENGNYLDINKKITSTSMKEHLREKFLKF 541

  Fly   818 W---LNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTKPAEDDNIIIM---QRSR 876
            |   ..::|.:     :.|    |...:||.      |....|     |.:|..::.:   ..|:
  Rat   542 WAVTFEMLPTV-----VGD----HTPPEDDS------EAAPVP-----PTDDSQVVPVPPTDDSQ 586

  Fly   877 TTTPPPPSKNPSTNATQALNPLGTG 901
            ||..||...:.:.::.:|..|:..|
  Rat   587 TTPVPPTDNSQAGDSVEAQMPVAIG 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	162/583 (28%)
Cel	NP_058693.2	COesterase	26..542	CDD:278561	172/689 (25%)
		Aes	<118..>247	CDD:223730	56/129 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612		16/74 (22%)
		4 X 11 AA tandem repeats, O-glycosylated region	556..599		12/53 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910