DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nlg2 and CES3

DIOPT Version :10

Sequence 1:NP_523496.1 Gene:Nlg2 / 33962 FlyBaseID:FBgn0031866 Length:1248 Species:Drosophila melanogaster
Sequence 2:NP_079198.2 Gene:CES3 / 23491 HGNCID:1865 Length:571 Species:Homo sapiens


Alignment Length:588 Identity:159/588 - (27%)
Similarity:246/588 - (41%) Gaps:127/588 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 LVLLLL----TSLWPDCCECLHGGSNTVKTKYGLLRG--IVVRSSP-LVEAFLGIPYASPPVGSL 219
            :|.|||    |:..|:..:      ..|.|..|.:||  :.|:.:. ||..|||||:|.||:|..
Human    15 VVCLLLACPATATGPEVAQ------PEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPD 73

  Fly   220 RFMPPITPSTWKTVRSADRFSPVCPQNIP------IPPNGPEALLEVPRARLAQLRRLLPLLKNQ 278
            ||..|.....|:.||.|....|:|.|::.      ...||.:.:..|                  
Human    74 RFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSV------------------ 120

  Fly   279 SEDCLYLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIV 343
            |||||.||:|.|.|       ....:|.|     .:|::||.:....:...||||.|||:|:|:|
Human   121 SEDCLVLNVYSPAE-------VPAGSGRP-----VMVWVHGGALITGAATSYDGSALAAYGDVVV 173

  Fly   344 VTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANI 408
            ||:.:|||:.||..| |.|.|.||.|.:|:||.|.|::||:..||||...:|:.|...|..:.:.
Human   174 VTVQYRLGVLGFFST-GDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISG 237

  Fly   409 LVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAEL 473
            ||:||||:.|..|.:..||...:|..|..:|..:.:::|....|.... ..::..||:.|...||
Human   238 LVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSS-PAEMVQCLQQKEGEEL 301

  Fly   474 LAVK----------VD------HPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEY 522
            :..|          ||      .|:.|:...||.....:....|...|..:|.|..::.|    .
Human   302 VLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDT----M 362

  Fly   523 ANFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDW 587
            ....:.|::...|.|.:.||:..                             |:...:.:||.. 
Human   363 EQMSREDMLAISTPVLTSLDVPP-----------------------------EMMPTVIDEYLG- 397

  Fly   588 EKAIRNPLSSRDATL------QFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHK-----TIEEE 641
                    |:.||..      :|:.|.....|.:.........|...:|..|:|:     .|:..
Human   398 --------SNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPA 454

  Fly   642 YPQRSGSVRGEDV---PFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVL 703
            :.:......|..|   ||.:.......|| ..|.:|:|:...|:...::||:||:||   :|::.
Human   455 WVKADHGAEGAFVFGGPFLMDESSRLAFP-EATEEEKQLSLTMMAQWTHFARTGDPN---SKALP 515

  Fly   704 PNP 706
            |.|
Human   516 PWP 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nlg2NP_523496.1 COesterase 182..729 CDD:395084 153/564 (27%)
CES3NP_079198.2 COesterase 32..547 CDD:395084 153/571 (27%)
Prevents secretion from ER. /evidence=ECO:0000255 568..571
Blue background indicates that the domain is not in the aligned region.

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