Protein Alignment Nlg2 and CES3

DIOPT Version :9

• Sequence 1: NP_001245916.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 159/588 - (27%)
• Similarity: 246/588 - (41%)
• Gaps: 127/588 - (21%)

  Fly   162 LVLLLL----TSLWPDCCECLHGGSNTVKTKYGLLRG--IVVRSSP-LVEAFLGIPYASPPVGSL 219
            :|.|||    |:..|:..:      ..|.|..|.:||  :.|:.:. ||..|||||:|.||:|..
Human    15 VVCLLLACPATATGPEVAQ------PEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPD 73

  Fly   220 RFMPPITPSTWKTVRSADRFSPVCPQNIP------IPPNGPEALLEVPRARLAQLRRLLPLLKNQ 278
            ||..|.....|:.||.|....|:|.|::.      ...||.:.:..|
Human    74 RFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSV------------------ 120

  Fly   279 SEDCLYLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIV 343
            |||||.||:|.|.|       ....:|.|     .:|::||.:....:...||||.|||:|:|:|
Human   121 SEDCLVLNVYSPAE-------VPAGSGRP-----VMVWVHGGALITGAATSYDGSALAAYGDVVV 173

  Fly   344 VTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANI 408
            ||:.:|||:.||..| |.|.|.||.|.:|:||.|.|::||:..||||...:|:.|...|..:.:.
Human   174 VTVQYRLGVLGFFST-GDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISG 237

  Fly   409 LVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAEL 473
            ||:||||:.|..|.:..||...:|..|..:|..:.:::|....|.... ..::..||:.|...||
Human   238 LVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSS-PAEMVQCLQQKEGEEL 301

  Fly   474 LAVK----------VD------HPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEY 522
            :..|          ||      .|:.|:...||.....:....|...|..:|.|..::.|    .
Human   302 VLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDT----M 362

  Fly   523 ANFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDW 587
            ....:.|::...|.|.:.||:..                             |:...:.:||..
Human   363 EQMSREDMLAISTPVLTSLDVPP-----------------------------EMMPTVIDEYLG- 397

  Fly   588 EKAIRNPLSSRDATL------QFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHK-----TIEEE 641
                    |:.||..      :|:.|.....|.:.........|...:|..|:|:     .|:..
Human   398 --------SNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPA 454

  Fly   642 YPQRSGSVRGEDV---PFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVL 703
            :.:......|..|   ||.:.......|| ..|.:|:|:...|:...::||:||:||   :|::.
Human   455 WVKADHGAEGAFVFGGPFLMDESSRLAFP-EATEEEKQLSLTMMAQWTHFARTGDPN---SKALP 515

  Fly   704 PNP 706
            |.|
Human   516 PWP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	153/564 (27%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	153/571 (27%)
		Aes	<129..>247	CDD:223730	52/130 (40%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810