Protein Alignment Nlg2 and Ces2c

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_663578.1
• Gene: Ces2c / 234671
• MGIID: 2385905
• Length: 561
• Species: Mus musculus
• Alignment Length: 574
• Identity: 164/574 - (28%)
• Similarity: 249/574 - (43%)
• Gaps: 127/574 - (22%)

  Fly   162 LVLLLLTSLWPDCCECLHGGSNTVK-TKYGLLRGIVVR---SSPLVEAFLGIPYASPPVGSLRFM 222
            |:|||:.....|..|     :|.:: |..|.::|.::.   :...|..|||||:|.||||.|||.
Mouse    17 LLLLLIHVQGQDSPE-----ANPIRNTHTGQIQGSLIHVKDTKAGVHTFLGIPFAKPPVGPLRFA 76

  Fly   223 PPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLL---PLLKNQSEDCLY 284
            ||..|..|..||.......:|.||:.:          :..|.|..::.:|   |:    ||||||
Mouse    77 PPEAPEPWSGVRDGTAHPAMCLQNLDM----------LNEAGLPDMKMMLSSFPM----SEDCLY 127

  Fly   285 LNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFR 349
            ||||.|.....            .:.|..:|:|||.:......:.:|||.|..:.:::||||.:|
Mouse   128 LNIYTPAHAHE------------GSNLPVMVWIHGGALVIGMASMFDGSLLTVNEDLVVVTIQYR 180

  Fly   350 LGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPV 414
            ||:.||..| |.:.|:||:|.:|..|.|.|:::|:..|||:|..:|:.|...|....:..||||:
Mouse   181 LGVLGFFST-GDQHARGNWGYLDQAAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPM 244

  Fly   415 ASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVK-- 477
            :..|....::.||.||.|..|.:....|...||:.:||.. |....|..|||.||.||:||:.
Mouse   245 SQGLFHGAIMESGVALLPDLISETSEMVSTTVAKLSGCEA-MDSQALVRCLRGKSEAEILAINKV 308

  Fly   478 -------VD------HPRFLVG---FAPFVDGTVISPGANPLG-STTLPLGSAIVSTSGIEYANF 525
                   ||      ||:.|:.   |.|.  .::|....:..| |..:.:|||.: ..||...|.
Mouse   309 FKMIPAVVDGEFFPRHPKELLASEDFHPV--PSIIGVNNDEFGWSIPVVMGSAQM-IKGITRENL 370

  Fly   526 PKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYT-DWEK 589
               ..:...|:|:..|.....||                               |..||. |.|.
Mouse   371 ---QAVLKDTAVQMMLPPECSDL-------------------------------LMEEYMGDTED 401

  Fly   590 AIRNPLSSRDATLQ-----FLSDGHTASPLIKLGYMHSLRGGRAYFLHFKH--KTIEEEYPQRSG 647
            |         .|||     .:.|.....|.:::.:..... ...||..|:|  ...::..|....
Mouse   402 A---------QTLQIQFTEMMGDFMFVIPALQVAHFQRSH-APVYFYEFQHPPSYFKDVRPPHVK 456

  Fly   648 SVRGEDVP------FWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPN 695
            :...:::|      || |:.:      ::|.:|..:.|.|::|.:|||:.||||
Mouse   457 ADHADEIPFVFASFFW-GMKL------DFTEEEELLSRRMMKYWANFARHGNPN 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	158/554 (29%)
Ces2c	NP_663578.1	COesterase	32..540	CDD:395084	158/554 (29%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561