Protein Alignment Nlg2 and Ces2b

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_937814.1
• Gene: Ces2b / 234669
• MGIID: 2448547
• Length: 556
• Species: Mus musculus
• Alignment Length: 611
• Identity: 169/611 - (27%)
• Similarity: 263/611 - (43%)
• Gaps: 121/611 - (19%)

  Fly   187 TKYGLLRGIVVR---SSPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIP 248
            |..|.:||.:|.   :...|..|||||:|.||||.|||.||..|..|..||.......:|.||:.
Mouse    38 THTGQVRGSLVHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMCLQNLG 102

  Fly   249 IPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEPKTKLST 313
            :               :.:::..||.: :.||||||||||.|.....            .:.|..
Mouse   103 V---------------MKEIKLKLPPV-STSEDCLYLNIYTPAHAHE------------GSNLPV 139

  Fly   314 VVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLH 378
            :|:|||........:.||||.|||..:::||||.:|||:.||..| |.:.|:||:|.:|.||.|.
Mouse   140 MVWIHGGGLVAGMASMYDGSLLAAIEDLVVVTIQYRLGVLGFFST-GDQHARGNWGFLDQVAALR 203

  Fly   379 WLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVK 443
            |:::|:..|||.|..:|:.|...|....:..||||::..|....::.||.||.|:.|......|.
Mouse   204 WIQQNIAHFGGKPDRVTIFGESAGGTSVSSHVVSPMSKGLFHGAIMESGVALLPYLITDTSEMVS 268

  Fly   444 RRVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVK---------VD------HPRFLVGFAPFVDG 493
            ..||:.:||.. |..:.|..|||.||.||:||:.         ||      ||:.|:....|
Mouse   269 TTVAKLSGCEA-MDSEALVRCLRGKSEAEILAINKLVQMIPAVVDGEFFPRHPKELLASEDF--- 329

  Fly   494 TVISPGANPLGSTTLPLGSAIVSTSGIEYA-NFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRR 557
                   :|:.|        |:..:..|:. ..|     ..:.|.::..:::.::|:.....|..
Mouse   330 -------HPVPS--------IIGVNNDEFGWTIP-----VVMGSAQTIKEITRENLQAVLKNTTA 374

  Fly   558 DRILRTFVRNNFHYHLNEIFAVLKNEYT-DWEKAIRNPLSSRDATLQ-----FLSDGHTASPLIK 616
            ..:|..           |...:|..||. |.|.|         .|||     .:.|.....|.::
Mouse   375 QLMLPP-----------ECSDLLMEEYMGDTEDA---------QTLQIQFTEMMEDFMFVIPALQ 419

  Fly   617 LGYMHSLRGGRAYFLHFKHK--TIEEEYPQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGR 679
            :.|....... .||..|:|:  ::::..|....:...:::||..|.....: ..::|..|:.:.|
Mouse   420 VAYFQRSHAS-VYFYEFQHQIASLKDVRPTHVKADHADEIPFVFGYFFWDM-KLDFTEGEKLLSR 482

  Fly   680 LMLRYLSNFAKTGNPNQSTAK--SVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQR 742
            .|::|.:|||:.||||.....  .|:.:..:.|:..           |.|.:..||      ..|
Mouse   483 RMMKYWANFARHGNPNSEGLPYWPVMDHDEQYLQLD-----------TQPAVGRAL------KSR 530

  Fly   743 RSNAMHEKRSYIRRRLRSNDAAFTQL 768
            |.....:..|...:.||::....|:|
Mouse   531 RLQFWTKTLSQKIQELRASQDKHTEL 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	160/570 (28%)
Ces2b	NP_937814.1	COesterase	32..535	CDD:395084	164/588 (28%)