Protein Alignment Nlg2 and NLGN1

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 872
• Identity: 267/872 - (30%)
• Similarity: 387/872 - (44%)
• Gaps: 254/872 - (29%)

  Fly   185 VKTKYGLLRGIVVRSS-----PLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCP 244
            |.|.:|.:|||....:     |::: |||:|||:||.|..||.||..||.|..:|:|.:|:||||
Human    55 VATNFGKIRGIKKELNNEILGPVIQ-FLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCP 118

  Fly   245 QNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYE----TRRQRRNTDD--- 302
            ||| |....||.:|.|....  .|..:...:::|||||||||||||.|    |::|   |||
Human   119 QNI-IDGRLPEVMLPVWFTN--NLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQ---TDDLGD 177

  Fly   303 ----------TTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLK 357
                      .:|.||   ..:|:|||.||...:||.||||.||::|||||:|:|:|||:.|||.
Human   178 NDGAEDEDIRDSGGPK---PVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLS 239

  Fly   358 TGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVA------- 415
            | |.::|:||:||:||:..|.|..||:..|||||..||:.|.|.|....|:|.:|..:
Human   240 T-GDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSN 303

  Fly   416 --SDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCH-GDMLYDDLAPCLRTKSVAELLAVK 477
              ..|.||.:..||:|||.||:...|....|.:|.:.||: .|.:  :|..||:.|...||:...
Human   304 STKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTV--ELVECLQKKPYKELVDQD 366

  Fly   478 VDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIF------CLTS 536
            :...|:.:.|.|.:||.||            |....|:...| |:.|:   |::.      .|..
Human   367 IQPARYHIAFGPVIDGDVI------------PDDPQILMEQG-EFLNY---DIMLGVNQGEGLKF 415

  Fly   537 VESYLD----LSAQDLEFGFNETRRDRILRTFVRNNFHYH-----LNEIFAVLKNEYTDWEKAIR 592
            ||:.:|    :||.|.:|.         :..||.|.:.|.     |.|   .:|..||||... .
Human   416 VENIVDSDDGISASDFDFA---------VSNFVDNLYGYPEGKDVLRE---TIKFMYTDWADR-H 467

  Fly   593 NPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFW 657
            ||.:.|...|...:|....:|.:....:||..|...||..|.|....::.|..:.:..|::||:.
Human   468 NPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYV 532

  Fly   658 LGLPM---SPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKK 719
            ||:||   :.|||.|::..:..:..:::.|.:||||||:|||       |.|.:.  ..:|
Human   533 LGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQ-------PVPQDT--KFIH---- 584

  Fly   720 RSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDEL 784
                 |.||                              |..:.|
Human   585 -----TKPN------------------------------RFEEVA-------------------- 594

  Fly   785 PFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRD 849
              |..|...:|||:.:|.|..::.|||.:|:::||.|:|.||   |:||
Human   595 --WTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLH---NLND---------------- 638

  Fly   850 LYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPSTNAT-----QALNPLGTGTPTTTECG 909
                                 |.|.:.|||     |.|||:.|     :...|:.:..||..:
Human   639 ---------------------ISQYTSTTT-----KVPSTDITFRPTRKNSVPVTSAFPTAKQ-- 675

  Fly   910 IDGAMSVSELTTTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATV 974
                         ..||...:.. .|: |:|                         |:|.|..|:
Human   676 -------------DDPKQQPSPF-SVD-QRD-------------------------YSTELSVTI 700

  Fly   975 AVGCFLLILNVLIFAGIYHQREKRARD 1001
            |||..||.||:|.||.:|::::||..|
Human   701 AVGASLLFLNILAFAALYYKKDKRRHD 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	208/593 (35%)
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	222/682 (33%)