Protein Alignment Nlg2 and NLGN4Y

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 930
• Identity: 277/930 - (29%)
• Similarity: 407/930 - (43%)
• Gaps: 261/930 - (28%)

  Fly   159 CALL---VLLLLTSL------------WPDCCECLHGGSNTVKTKYGLLRGIVVRSSPL------ 202
            |.:|   |||.:|:|            :|           .|.|.||.::|:   .:||
Human    18 CVMLNSNVLLWITALAIKFTLIDSQAQYP-----------VVNTNYGKIQGL---RTPLPSEILG 68

  Fly   203 -VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALL---EVPRA 263
             ||.:||:||||||.|..||.||.:||:|..:|:|.:||.||||::      .|..|   .:|..
Human    69 PVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQFSAVCPQHL------DERFLLHDMLPIW 127

  Fly   264 RLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQ-RRNTDDTT----GEPK------TKLSTVVFI 317
            ....|..|:..:::|:|||||||||||.|.... :||.||.|    ||.|      :|...:|:|
Human   128 FTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSNDHGEDKDIHEQNSKKPVMVYI 192

  Fly   318 HGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKE 382
            ||.||...:||..|||.||::|||||:|||:||||.|||.| |.::|:||:||:|.:..|.|::|
Human   193 HGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLST-GDQAAKGNYGLLDQIQALRWIEE 256

  Fly   383 NLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVA 447
            |:.||||||:.:|:.|.|.||...::|.:|..:..|.|:.::.||:|||.||:...|....|.:|
Human   257 NVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILA 321

  Fly   448 EQTGCHGDML-YDDLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLG 511
            ::.||  :|| ..|:..||:.|:..||:...:....:.:.|.|.:||.||            |..
Human   322 DKVGC--NMLDTTDMVECLKNKNYKELIQQTITPATYHIAFGPVIDGDVI------------PDD 372

  Fly   512 SAIVSTSGIEYANFPKRDLIFCLTSVE--SYLDLSAQDLEFGFNETRRDRILRTFVRNNFHY--- 571
            ..|:...| |:.|:   |::..:...|  .::| ...|.|.|......|..:..||.|.:.|
Human   373 PQILMEQG-EFLNY---DIMLGVNQGEGLKFVD-GIVDNEDGVTPNDFDFSVSNFVDNLYGYPEG 432

  Fly   572 --HLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFK 634
              .|.|   .:|..||||... .||.:.|...:...:|....:|.:....:|:..|...||..|.
Human   433 KDTLRE---TIKFMYTDWADK-ENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFY 493

  Fly   635 HKTIEEEYPQRSGSVRGEDVPFWLGLPM---SPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQ 696
            |....|..|..:.|..|::||:..|:||   :.||..|::..:..:..:::.|.:||||||:|||
Human   494 HHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQ 558

  Fly   697 STAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSN 761
                   |.|.:.  ..:|         |.||                              |..
Human   559 -------PVPQDT--KFIH---------TKPN------------------------------RFE 575

  Fly   762 DAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLH 826
            :.|                      |..|:..:|||:.:|.|..::.|||..|::.||.|:|.||
Human   576 EVA----------------------WSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLH 618

  Fly   827 RHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPSTNA 891
               |:|:                                     |.|...|||..||....|.
Human   619 ---NLNE-------------------------------------IFQYVSTTTKVPPPDMTSF-- 641

  Fly   892 TQALNPLGTGT------PTTTECGIDGAMSVSELTTTQSPK----DNRTG----IVRVETQKDLA 942
                 |.||..      |||....|         |...:||    .::||    .|.:||::|
Human   642 -----PYGTRRSPAKIWPTTKRPAI---------TPANNPKHSKDPHKTGPEDTTVLIETKRD-- 690

  Fly   943 TASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQREKRARDAKTKEE 1007
                                   |:|.|..|:|||..||.||:|.||.:|::::||..:......
Human   691 -----------------------YSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRHPS 732

  Fly  1008 LQEGDNS-----KNSSILKL 1022
            .|....:     :|..|:.|
Human   733 PQRNTTNDITHIQNEEIMSL 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	202/578 (35%)
NLGN4Y	NP_001352513.1	COesterase	44..610	CDD:395084	217/679 (32%)