Protein Alignment Nlg2 and CES5A

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_001177087.1
• Gene: CES5A / 221223
• HGNCID: 26459
• Length: 604
• Species: Homo sapiens
• Alignment Length: 660
• Identity: 175/660 - (26%)
• Similarity: 266/660 - (40%)
• Gaps: 173/660 - (26%)

  Fly   187 TKYGLLRG--IVVRSSPL-VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIP 248
            |:.|.::|  :.|..||: |..|||:|:|:||:|||||..|...|.|..:|.|..:..:|.||
Human    64 TRLGWIQGKQVTVLGSPVPVNVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQN-- 126

  Fly   249 IPPNGPEALLEVPRARLAQLRRLLPLLK------NQSEDCLYLNIYVPYETRRQRRNTDDTTGEP 307
                 .|.||      |.|     .:||      ..||||||||||.|...         .||
Human   127 -----SEWLL------LDQ-----HMLKVHYPKFGVSEDCLYLNIYAPAHA---------DTG-- 164

  Fly   308 KTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMD 372
             :||..:|:..|.::...|.:.:|||.|||:.:|:||.:.:|||||||..| ..:.|.||:...|
Human   165 -SKLPVLVWFPGGAFKTGSASIFDGSALAAYEDVLVVVVQYRLGIFGFFTT-WDQHAPGNWAFKD 227

  Fly   373 LVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQK 437
            .||.|.|:::|:..|||||.|:|:.|...||:..:.|::||:|..|..:.::.||.|:.|:....
Human   228 QVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAKGLFHKAIMESGVAIIPYLEAH 292

  Fly   438 NPLFVKRRVAEQTGCH--GDMLYDD--LAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISP 498
            :   .::....|...|  |:...|.  |..|||||...|||.:.    :....|...|||... |
Human   293 D---YEKSEDLQVVAHFCGNNASDSEALLRCLRTKPSKELLTLS----QKTKSFTRVVDGAFF-P 349

  Fly   499 GANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRT 563
            . .||...:.....||.|..|:.     ..:..|.|...|      |.::..|.|::    :...
Human   350 N-EPLDLLSQKAFKAIPSIIGVN-----NHECGFLLPMKE------APEILSGSNKS----LALH 398

  Fly   564 FVRNNFH-----YHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSL 623
            .::|..|     .||      :.|||...:.::   ...||:.|..|.|.....|.:.....|..
Human   399 LIQNILHIPPQYLHL------VANEYFHDKHSL---TEIRDSLLDLLGDVFFVVPALITARYHRD 454

  Fly   624 RGGRAYFLHFKHK--TIEEEYPQRSGSVRGEDVPFWLG---LPMSPLFPHNYTTQERQIGRLMLR 683
            .|...||..|:|:  ..|:..|....:...::|.|..|   |....:.....|.:|:.:.|.|::
Human   455 AGAPVYFYEFRHRPQCFEDTKPAFVKADHADEVRFVFGGAFLKGDIVMFEGATEEEKLLSRKMMK 519

  Fly   684 YLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMH 748
            |.:.||:|||||
Human   520 YWATFARTGNPN----------------------------------------------------- 531

  Fly   749 EKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGH 813
                                            |::|..|.||::..| |::|....::....:..
Human   532 --------------------------------GNDLSLWPAYNLTEQ-YLQLDLNMSLGQRLKEP 563

  Fly   814 KLSMWLNLIP 823
            ::..|.:.||
Human   564 RVDFWTSTIP 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	164/564 (29%)
CES5A	NP_001177087.1	COesterase	58..568	CDD:395084	172/653 (26%)