DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and Nlgn2

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_001351066.1	Gene:	Nlgn2 / 216856	MGIID:	2681835	Length:	836	Species:	Mus musculus

Alignment Length:	1042	Identity:	287/1042 - (27%)
Similarity:	425/1042 - (40%)	Gaps:	309/1042 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 VKTKYGLLRGIVVRS-------SPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPV 242
            |.|.||.:||  ||.       .|:|: |||:|||:||:|:.||.||..|::|..||:|....|.
Mouse    44 VNTAYGRVRG--VRRELNNEILGPVVQ-FLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPA 105

  Fly   243 CPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEP 307
            ||||:    :|....:.:|......|......::||||||||||:|||.|.....:..|:.|..|
Mouse   106 CPQNL----HGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNP 166

  Fly   308 -------KTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQ 365
                   ..|...::|:||.||...:||.:|||.|||:|||||||:|:|||:.|||.| |.::|:
Mouse   167 PDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVVTLNYRLGVLGFLST-GDQAAK 230

  Fly   366 GNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSAL 430
            ||:||:|.:..|.||.||:..|||||:.||:.|.|.||...|:|::|..:..|.|:.:..||:|:
Mouse   231 GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAI 295

  Fly   431 SPWAIQKNPLFVKRRVAEQTGCHGDMLYD--DLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDG 493
            |.|::...||...|.:|.:.||..:   |  :...|||.||..||:...|...|:.:.|.|.|||
Mouse   296 SSWSVNYQPLKYTRLLAAKVGCDRE---DSTEAVECLRRKSSRELVDQDVQPARYHIAFGPVVDG 357

  Fly   494 TVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVE--SYLDLSAQDLEFGFNETR 556
            .|:            |....|:...| |:.|:   |::..:...|  .:::.||:. |.|.:.:.
Mouse   358 DVV------------PDDPEILMQQG-EFLNY---DMLIGVNQGEGLKFVEDSAES-EDGVSASA 405

  Fly   557 RDRILRTFVRNNFHYH-----LNEIFAVLKNEYTDWEKAIR-NPLSSRDATLQFLSDGHTASPLI 615
            .|..:..||.|.:.|.     |.|   .:|..||||  |.| |....|...|...:|....:|.:
Mouse   406 FDFTVSNFVDNLYGYPEGKDVLRE---TIKFMYTDW--ADRDNGEMRRKTLLALFTDHQWVAPAV 465

  Fly   616 KLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPM---SPLFPHNYTTQERQI 677
            ....:|:......||..|.|....|..|:.:.:..|:::|:..|:||   :.|||.|::..:..:
Mouse   466 ATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVML 530

  Fly   678 GRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQR 742
            ..:::.|.:||||||:|||       |.|.:.  ..:|         |.||..|.:
Mouse   531 SAVVMTYWTNFAKTGDPNQ-------PVPQDT--KFIH---------TKPNRFEEV--------- 568

  Fly   743 RSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQ 807
                                                       .|..::...:.|:.:|.|..::
Mouse   569 -------------------------------------------VWSKFNSKEKQYLHIGLKPRVR 590

  Fly   808 SHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVR-PQLQTKPAEDDNIII 871
            .:||.:|::.||.|:|.||   |:               :.:|:....| |...|:
Mouse   591 DNYRANKVAFWLELVPHLH---NL---------------HTELFTTTTRLPPYATR--------- 628

  Fly   872 MQRSRTTTPPPPSKNPSTNATQALNPLGTGTPTTTECGIDGAMSVSELTTTQSPKDNRTGIVRVE 936
                    .||.:..|.|:.|:...|..|..|   |..||    :......:.|.|:|
Mouse   629 --------WPPRTPGPGTSGTRRPPPPATLPP---ESDID----LGPRAYDRFPGDSR------- 671

  Fly   937 TQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQREKRARD 1001
                                        .|:|.|..|||||..||.||:|.||.:|::|::|
Mouse   672 ----------------------------DYSTELSVTVAVGASLLFLNILAFAALYYKRDRR--- 705

  Fly  1002 AKTKEELQEGDNSKNSSILKLNALMGGGGACGSG-PGDIADAYTLSGSVVDSKGGVGVVFGEYSC 1065
                   ||         |:...|...||: ||| ||        .|.::.:.|.
Mouse   706 -------QE---------LRCRRLSPPGGS-GSGVPG--------GGPLLPTAGR---------- 735

  Fly  1066 YDEKTKQLKEEKLLVELPPSSSTGQTSLMIDNWGACSTSTLDLLKTKPGDPIEMVTYSALPSVME 1130
                           ||||....  .||.:...|...           .||.|.:..:..|
Mouse   736 ---------------ELPPEEEL--VSLQLKRGGGVG-----------ADPAEALRPACPP---- 768

  Fly  1131 STSAMSSKRGSFVDTTLQFNSPQQFDYAVQSSDQMSFKAIEDAVKAAAGHDSEITRDDDIPEPPP 1195
                         |.||...                 :|.:|....|.|..:.:......|.|||
Mouse   769 -------------DYTLALR-----------------RAPDDVPLLAPGALTLLPSGLGPPPPPP 803

  Fly  1196 PP 1197
            ||
Mouse   804 PP 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	195/553 (35%)
Nlgn2	NP_001351066.1	COesterase	42..601	CDD:306613	207/659 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..661		13/61 (21%)
		Required for interaction with LHFPL4. /evidence=ECO:0000269\|PubMed:28279354	679..699		12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..735		9/32 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..836		6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	360	1.000	Domainoid score	I955
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8833
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.880