DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg2 and cest-30

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_504407.1	Gene:	cest-30 / 181871	WormBaseID:	WBGene00015071	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	591	Identity:	151/591 - (25%)
Similarity:	245/591 - (41%)	Gaps:	118/591 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 CALLVLL---LLTSLWPDCCECLHGGSNTVKTKYGLLRGIVVR---SSPLVEAFLGIPYASPPVG 217
            |.||.::   .|.:|.|:      ..|..:....|.:||.:.:   .:.:|:.:||||:|..|||
Worm    11 CLLLSIVEGGFLVNLTPE------KNSQILNAPCGPIRGNIYKHKNGTKIVDGYLGIPFAKAPVG 69

  Fly   218 SLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDC 282
            :|:|..|:....|...|....:.|.|||.     ....||.....|..|:            |:|
Worm    70 ALKFKKPVAAEKWTEPRDCYEYGPGCPQT-----GRFAALTAKSTAAFAE------------ENC 117

  Fly   283 LYLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAH---GNVIVV 344
            |.||::.|    |.:      ..|....|..:|:|:|..|:....:..|...|...   .:||||
Worm   118 LTLNVFAP----RWK------LAEFPKGLPVLVYIYGGGYEIGFTSYMDDYSLTGTLPLKDVIVV 172

  Fly   345 TINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANIL 409
            |:|:|||..||| |.....|.||:||.|....|.|:::|:.:|||:|:|:||.|...||...:.|
Worm   173 TMNYRLGPLGFL-TIADGIANGNYGLWDQTLALQWVQDNIASFGGNPESVTLSGTSAGATSTDFL 236

  Fly   410 VVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQ-------TGCHGDMLYDDLAPCLRT 467
            .:||.::.|.||::.:||:|...:||:  |..|:..|.::       ||.....|:|
Worm   237 SLSPHSNQLFQRSISMSGTAFCNFAIR--PKDVEVGVCKEFAQFQGYTGTDSQSLFD-------- 291

  Fly   468 KSVAELLAVKVDHPRFLVGFAPFVDGTV-ISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLI 531
                ..:|..|...:.:.||.....|.| ..|..:         |........|.....||:|.:
Worm   292 ----WYMAQNVSKFKEVAGFQSTAAGAVPFIPNFD---------GDFFPKPFDILRREAPKKDAL 343

  Fly   532 FCLTSVESYLDLSAQDLEFG---FNETRRDRILRTFVRNNFHYHLNEIFAV-LKNEYTDWEKA-- 590
            ..:.::||          .|   ||.      |.....|||...:||.:.. :.:.|.|.:|.
Worm   344 ITVVTMES----------VGMIIFNP------LFANAYNNFEGFINETYGPDVTDYYADVKKKLT 392

  Fly   591 ---IRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLR-----GGRAY---FLHFKHKT---IEEE 641
               :::..:|..||:......:.:..:...|.:.:::     |.:.|   |.:|...|   :|..
Worm   393 GFYLKDVNASDKATVNRRVVDYVSDSVFNSGTLDAVKSYVKYGNKVYLGSFNYFNDATKDMVELM 457

  Fly   642 YPQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPN-QSTAKSVLP- 704
            .|.:..| ...|..::.|..:...|  ..|.:|.::..:....::||.|.|:|| :|..|...|
Worm   458 QPFKEAS-HSSDFKYYFGSGVMANF--TPTDEEMEVMDMSGTLMANFVKYGDPNGKSGTKPWKPY 519

  Fly   705 ---NPN 707
               .||
Worm   520 TILKPN 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	145/565 (26%)
cest-30	NP_504407.1	COesterase	31..539	CDD:278561	145/565 (26%)
cest-30	NP_504407.1	Aes	<122..>230	CDD:223730	40/118 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900