DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg2 and ace-1

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_510660.1	Gene:	ace-1 / 181706	WormBaseID:	WBGene00000035	Length:	620	Species:	Caenorhabditis elegans

Alignment Length:	750	Identity:	187/750 - (24%)
Similarity:	283/750 - (37%)	Gaps:	246/750 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 LHGGS----NTVKTKYGLLRGIVVRSSPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADR 238
            ||.||    ..|.::.|         .||.. |.|||:|.||||:|||..|.....|:
Worm    23 LHDGSPLFGEEVLSQTG---------KPLTR-FQGIPFAEPPVGNLRFKKPKPKQPWR------- 70

  Fly   239 FSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQ-------------------SEDCLY 284
                .|.|...|||.                    .::::                   ||||||
Worm    71 ----IPLNATTPPNS--------------------CIQSEDTYFGDFYGSTMWNANTKLSEDCLY 111

  Fly   285 LNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSG----NPYDGSELAAHGNVIVVT 345
            ||:|||.:.            :|..||:.:|:::|..: | ||    :.|||..|....|||:|.
Worm   112 LNVYVPGKV------------DPNKKLAVMVWVYGGGF-W-SGTATLDVYDGRILTVEENVILVA 162

  Fly   346 INFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILV 410
            :|:|:.|||||.....| |.||.|:.|.:..:.|:.:|:..||||...|||.|...||...:|.:
Worm   163 MNYRVSIFGFLYMNRPE-APGNMGMWDQLLAMKWVHKNIDLFGGDLSRITLFGESAGAASVSIHM 226

  Fly   411 VSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVA--EQTGCHGDML-----YDDLAPCLRTK 468
            :||.::....|.::.||||.|||||:...:.:.|.|.  ....| |:|.     ||.:..|.: :
Worm   227 LSPKSAPYFHRAIIQSGSATSPWAIEPRDVALARAVILYNAMKC-GNMSLINPDYDRILDCFQ-R 289

  Fly   469 SVAELLAVKV--------DHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANF 525
            :.|:.|....        |.|     :.|.|||..:...|    .|:|..|            ||
Worm   290 ADADALRENEWAPVREFGDFP-----WVPVVDGDFLLENA----QTSLKQG------------NF 333

  Fly   526 PKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAV----LKNEYTD 586
            .|..|:......||...|:                          |.|.:||.|    .|.::..
Worm   334 KKTQLLAGSNRDESIYFLT--------------------------YQLPDIFPVADFFTKTDFIK 372

  Fly   587 ----WEKAIRN-------------------------PLSSRD---ATLQFLSDGHTASPLIKLGY 619
                |.|.:::                         |::.||   |..:.|.|.|....:.::..
Worm   373 DRQLWIKGVKDLLPRQILKCQLTLAAVLHEYEPQDLPVTPRDWINAMDKMLGDYHFTCSVNEMAL 437

  Fly   620 MHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRY 684
            .|:..||..|:.:|.|:..::.:|:..|.:.|.::.|..|.|::.. ..|||.:||::....:||
Worm   438 AHTKHGGDTYYYYFTHRASQQTWPEWMGVLHGYEINFIFGEPLNQK-RFNYTDEERELSNRFMRY 501

  Fly   685 LSNFAKTGNPNQ----STAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSN 745
            .:||||||:||:    |..:.|.|..|.|
Worm   502 WANFAKTGDPNKNEDGSFTQDVWPKYNSV------------------------------------ 530

  Fly   746 AMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHY 810
                ...|:...:.|:..:..::|....|       .|..||.||     |...:...|::...|
Worm   531 ----SMEYMNMTVESSYPSMKRIGHGPRR-------KECAFWKAY-----LPNLMAAVADVGDPY 579

  Fly   811 RGHKLSM--WLN-LIPQLHRHFNINDQSMRHHQFQ 842
            ...|..|  |.| .|.....||   :|..|:..::
Worm   580 LVWKQQMDKWQNEYITDWQYHF---EQYKRYQTYR 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	163/611 (27%)
ace-1	NP_510660.1	COesterase	13..561	CDD:278561	171/690 (25%)
ace-1	NP_510660.1	Aes	<114..>249	CDD:223730	53/149 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910