DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and nlg-1

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_001257226.1	Gene:	nlg-1 / 181484	WormBaseID:	WBGene00006412	Length:	847	Species:	Caenorhabditis elegans

Alignment Length:	891	Identity:	272/891 - (30%)
Similarity:	402/891 - (45%)	Gaps:	217/891 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 TVKTKYGLLRGIVVRSS----PLVEAFLGIPYASPPVGSLRFMPPITPSTWKTV-RSADRFSPVC 243
            :|.|.:|::||.||...    |.|..:|||||...|.|..||...|:.:.|..: :.|.:.||||
Worm    22 SVTTSWGMVRGEVVSPEGDDLPPVAQYLGIPYGVAPTGQYRFNMAISAAKWTHMPKDARKVSPVC 86

  Fly   244 PQNIPIPPNGPEALLEVPRARL-----AQL----RRLLPLLKNQSEDCLYLNIYVPYETRRQRRN 299
                 |..:.|| |.|..|.|.     ||.    .||||.||.|||||||:|||||......|.|
Worm    87 -----IQTDMPE-LSETKRFRAFKHTSAQRFDFNHRLLPHLKKQSEDCLYMNIYVPERLEISRDN 145

  Fly   300 TDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESA 364
                      .|..:|.:|||.|.|.:||.::|:.|||:|::||||:|:|||:||||......|.
Worm   146 ----------YLPVMVIVHGEEYGWGTGNAFNGTTLAAYGHIIVVTLNYRLGVFGFLGRCESSSC 200

  Fly   365 QGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASD---LIQRTVLVS 426
            .||.|:.|||:.|..|...||:||||.:|:||.|:|:||.|.::|:.||:...   |.:|.:|:.
Worm   201 SGNSGISDLVSALTMLNVILPSFGGDSKSVTLAGWGSGASLVSLLMASPLTQPGRRLFRRAILLD 265

  Fly   427 GSALSPWAIQKNPLFVKRRVAEQTGC--------HGDMLYDDLAPCLRTKSVAEL--LAVKVDHP 481
            |||||||||.:||.....::||:..|        ..|.: |.:..|::..|...:  ..:|:|.|
Worm   266 GSALSPWAISQNPQQYFMQLAEELACAPKNRTSSFNDNV-DTIVRCMQVHSSENITKAVLKIDVP 329

  Fly   482 RFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQ 546
            .||.||||.|||.:| |. .|..|.:...||.           |.:.||:..::|..|:..:|.:
Worm   330 TFLSGFAPIVDGQLI-PN-KPQVSFSTQYGSL-----------FREIDLLVGISSNPSHHMISNE 381

  Fly   547 DLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTA 611
            ||:.|.::.:|.||.|:.|||.:.:|..||.|.:.|||||||....:|.|.|:..|..|||....
Worm   382 DLKVGISKEKRMRIFRSLVRNLYDFHREEILASIINEYTDWENPRDHPKSIRNGVLNALSDVLYT 446

  Fly   612 SPLIKLGYMHSL----RGGRAYFLHFKHKT--IEEEYPQRS--GSVRGEDVPFWLGLPMSP---- 664
            :|||:....||.    :....:...|.|:|  ..:|.|...  ||:.|:.||:..|.|::.
Worm   447 APLIETLRSHSADEVRKEANTFMFAFAHETRSWSQEQPNSGIRGSLSGDIVPYIFGYPLAQGDSE 511

  Fly   665 --LFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHP 727
              |: ..:.|.::.|.::|:.|:|||.|:|:|::       |||
Worm   512 ERLY-SGFNTDDKGISKVMMHYVSNFVKSGDPSK-------PNP--------------------- 547

  Fly   728 NLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDV 792
             :|:...:..:::   |.|                                        |..:|.
Worm   548 -MSKNFPMGDVFH---STA----------------------------------------WPQFDQ 568

  Fly   793 VN-QLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVR 856
            .| :.|:|:.::..::::||..::..|.|.|||||::....:.....|....|...:|.|.|..|
Worm   569 PNREAYLEITDRPRVKNYYRNAQVGFWNNFIPQLHKNGKETEPVGEEHHLLSDHFRKDSYFGKTR 633

  Fly   857 PQLQTKPAEDDNIIIMQRSRTTTP-PPPSKNPSTNATQALNPLGTGTPTTTECGIDGAMSVSELT 920
                           ...|....| |||...||........|..:.:|||.:            |
Worm   634 ---------------HFSSYANLPFPPPPMPPSPPPELTTKPKPSESPTTLQ------------T 671

  Fly   921 TTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNV 985
            ||             |::|..|.:.||        :.|||            .:.:||..||:||
Worm   672 TT-------------ESEKAAAGSFTG--------KALGG------------VIFIGCGFLIMNV 703

  Fly   986 LIFAGIYHQREKRARDAKTKEELQEGDNSKNSSILKLNALMGGGGA 1031
            .:...:..:..|:.|:.| |.:||....:.|.          ||||
Worm   704 CLLIAVRREWGKKRRNEK-KFQLQYQTYNSNH----------GGGA 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	210/568 (37%)
nlg-1	NP_001257226.1	COesterase	22..595	CDD:365897	220/675 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	330	1.000	Domainoid score	I615
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H84460
Inparanoid	1	1.050	363	1.000	Inparanoid score	I1271
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14500
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.100