Protein Alignment Nlg2 and nlg-1

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_001257226.1
• Gene: nlg-1 / 181484
• WormBaseID: WBGene00006412
• Length: 847
• Species: Caenorhabditis elegans
• Alignment Length: 891
• Identity: 272/891 - (30%)
• Similarity: 402/891 - (45%)
• Gaps: 217/891 - (24%)

  Fly   184 TVKTKYGLLRGIVVRSS----PLVEAFLGIPYASPPVGSLRFMPPITPSTWKTV-RSADRFSPVC 243
            :|.|.:|::||.||...    |.|..:|||||...|.|..||...|:.:.|..: :.|.:.||||
 Worm    22 SVTTSWGMVRGEVVSPEGDDLPPVAQYLGIPYGVAPTGQYRFNMAISAAKWTHMPKDARKVSPVC 86

  Fly   244 PQNIPIPPNGPEALLEVPRARL-----AQL----RRLLPLLKNQSEDCLYLNIYVPYETRRQRRN 299
                 |..:.|| |.|..|.|.     ||.    .||||.||.|||||||:|||||......|.|
 Worm    87 -----IQTDMPE-LSETKRFRAFKHTSAQRFDFNHRLLPHLKKQSEDCLYMNIYVPERLEISRDN 145

  Fly   300 TDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESA 364
                      .|..:|.:|||.|.|.:||.::|:.|||:|::||||:|:|||:||||......|.
 Worm   146 ----------YLPVMVIVHGEEYGWGTGNAFNGTTLAAYGHIIVVTLNYRLGVFGFLGRCESSSC 200

  Fly   365 QGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASD---LIQRTVLVS 426
            .||.|:.|||:.|..|...||:||||.:|:||.|:|:||.|.::|:.||:...   |.:|.:|:.
 Worm   201 SGNSGISDLVSALTMLNVILPSFGGDSKSVTLAGWGSGASLVSLLMASPLTQPGRRLFRRAILLD 265

  Fly   427 GSALSPWAIQKNPLFVKRRVAEQTGC--------HGDMLYDDLAPCLRTKSVAEL--LAVKVDHP 481
            |||||||||.:||.....::||:..|        ..|.: |.:..|::..|...:  ..:|:|.|
 Worm   266 GSALSPWAISQNPQQYFMQLAEELACAPKNRTSSFNDNV-DTIVRCMQVHSSENITKAVLKIDVP 329

  Fly   482 RFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQ 546
            .||.||||.|||.:| |. .|..|.:...||.           |.:.||:..::|..|:..:|.:
 Worm   330 TFLSGFAPIVDGQLI-PN-KPQVSFSTQYGSL-----------FREIDLLVGISSNPSHHMISNE 381

  Fly   547 DLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTA 611
            ||:.|.::.:|.||.|:.|||.:.:|..||.|.:.|||||||....:|.|.|:..|..|||....
 Worm   382 DLKVGISKEKRMRIFRSLVRNLYDFHREEILASIINEYTDWENPRDHPKSIRNGVLNALSDVLYT 446

  Fly   612 SPLIKLGYMHSL----RGGRAYFLHFKHKT--IEEEYPQRS--GSVRGEDVPFWLGLPMSP---- 664
            :|||:....||.    :....:...|.|:|  ..:|.|...  ||:.|:.||:..|.|::.
 Worm   447 APLIETLRSHSADEVRKEANTFMFAFAHETRSWSQEQPNSGIRGSLSGDIVPYIFGYPLAQGDSE 511

  Fly   665 --LFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHP 727
              |: ..:.|.::.|.::|:.|:|||.|:|:|::       |||
 Worm   512 ERLY-SGFNTDDKGISKVMMHYVSNFVKSGDPSK-------PNP--------------------- 547

  Fly   728 NLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDV 792
             :|:...:..:::   |.|                                        |..:|.
 Worm   548 -MSKNFPMGDVFH---STA----------------------------------------WPQFDQ 568

  Fly   793 VN-QLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVR 856
            .| :.|:|:.::..::::||..::..|.|.|||||::....:.....|....|...:|.|.|..|
 Worm   569 PNREAYLEITDRPRVKNYYRNAQVGFWNNFIPQLHKNGKETEPVGEEHHLLSDHFRKDSYFGKTR 633

  Fly   857 PQLQTKPAEDDNIIIMQRSRTTTP-PPPSKNPSTNATQALNPLGTGTPTTTECGIDGAMSVSELT 920
                           ...|....| |||...||........|..:.:|||.:            |
 Worm   634 ---------------HFSSYANLPFPPPPMPPSPPPELTTKPKPSESPTTLQ------------T 671

  Fly   921 TTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNV 985
            ||             |::|..|.:.||        :.|||            .:.:||..||:||
 Worm   672 TT-------------ESEKAAAGSFTG--------KALGG------------VIFIGCGFLIMNV 703

  Fly   986 LIFAGIYHQREKRARDAKTKEELQEGDNSKNSSILKLNALMGGGGA 1031
            .:...:..:..|:.|:.| |.:||....:.|.          ||||
 Worm   704 CLLIAVRREWGKKRRNEK-KFQLQYQTYNSNH----------GGGA 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	210/585 (36%)
nlg-1	NP_001257226.1	COesterase	19..595	CDD:395084	220/675 (33%)