Protein Alignment Nlg2 and cest-3

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_510042.2
• Gene: cest-3 / 181385
• WormBaseID: WBGene00008451
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 626
• Identity: 143/626 - (22%)
• Similarity: 224/626 - (35%)
• Gaps: 191/626 - (30%)

  Fly   178 LHG-GSNTVKTKYGLLRGIVVRSSPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSP 241
            |:| |...:.|.||.|.|..|....  ..|..:|:|.||:|.|||..|...:.||.:|:|..:||
 Worm    16 LNGSGQRIISTTYGKLEGKTVNVDQ--HMFKNVPFAKPPLGKLRFSLPEWTNPWKNIRNATEYSP 78

  Fly   242 VCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGE 306
            .|..|..:..:.                ...|:    ||||||||::           |::...:
 Worm    79 SCFSNSSMRTDS----------------NFFPM----SEDCLYLNVF-----------TNEYCLK 112

  Fly   307 PKTKLSTVVFIHGESYDWNSGNPYDGS---ELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNF 368
            .| ..||||:.||...:.:|...::.:   |.....||:.:...:||||||.|..|.......|.
 Worm   113 SK-NCSTVVYYHGGGINMDSAVQFNDTFILERYVKENVVFIIPAYRLGIFGLLYFGSNNLVPQNL 176

  Fly   369 GLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVS-PVASD--LIQRTVLVSGSAL 430
            .:.|....|.::.:.:..|||....|.|:|:..||.::.|...| .:..|  ||.|.::     |
 Worm   177 AIHDCELALRFIHQEISNFGGHKDDINLMGHSAGAHISLIFGFSRHIDPDHKLINRIIV-----L 236

  Fly   431 SPWAIQKNP-LFVKR--RVAEQTGCHGDMLY---DDLAPCLRTKSVAELLAVK--VDHPR----- 482
            ||......| |.:|.  ..||:.||:...:.   .::..|||.|....|::::  :::.|
 Worm   237 SPVPSYDMPELLIKNCYDFAERVGCYKRNVTARDTEIVKCLRKKDARGLMSMQRLMENDRLYFWN 301

  Fly   483 FLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQD 547
            ||.| .||:                                                |.|.|..|
 Worm   302 FLAG-EPFM------------------------------------------------YRDESIAD 317

  Fly   548 LEFGFNE--TRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPL------------SSR 598
                |.|  .:||.::...|.......|.:....:...:.|||    ||.            :..
 Worm   318 ----FKEYAVKRDMLIGNTVDEVKWKRLKKENPAIAGSFMDWE----NPYEVAHKFNFYHDSAPV 374

  Fly   599 DATLQFLSDG---HTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGL 660
            ::|.:..:.|   .||:    .....:..||..|..        :...|.|..|  .|:.:::|
 Worm   375 NSTYESFTQGIFVSTAT----YAEAQANAGGTVYLF--------QSNQQPSSHV--SDMQYFVG- 424

  Fly   661 PMSPLFPHNYTTQERQI-GRLMLRYLSNFAKTGNPNQ-----------------STAKSVLPNPN 707
                ....:|.|.:..| .....:.:.||.|.|:|:.                 :|.|.:.|...
 Worm   425 ----THREDYHTSDMDIMDTFYSKMIVNFTKFGSPSPVWEPLVPSRMNYYALEVNTEKGIWPRME 485

  Fly   708 E---------------VLETALHQQKKRS--TSLT----HP 727
            |               ..:..:.:|||.|  ||||    ||
 Worm   486 EDFHESDVNFWFINMTAFDREVTRQKKTSNGTSLTWSPMHP 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	140/621 (23%)
cest-3	NP_510042.2	alpha/beta hydrolases	21..496	CDD:473884	130/589 (22%)