Protein Alignment Nlg2 and cest-19

DIOPT Version :9

• Sequence 1: NP_001245916.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_509187.4
• Gene: cest-19 / 180973
• WormBaseID: WBGene00020125
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 648
• Identity: 172/648 - (26%)
• Similarity: 265/648 - (40%)
• Gaps: 144/648 - (22%)

  Fly   184 TVKTKY----------GLLRG-IVVRSSPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSAD 237
            |:.|::          |.:|| .::........|.|||:|.||||.|||..|..|:.|:.|.:|.
 Worm    17 TISTRHISPFELRVNSGAIRGERLLTDGQDYSVFKGIPFAMPPVGYLRFQMPKEPAKWRGVMNAT 81

  Fly   238 RFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIY--VPYETRRQRRNT 300
            ::|.:|.|||.....|.      |...:|.:          ||||||||::  .||:      .|
 Worm    82 QYSAMCMQNIDENDAGE------PERYVAHV----------SEDCLYLNVFSPTPYQ------YT 124

  Fly   301 DDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGN-----VIVVTINFRLGIFGFLKTGG 360
            :||       ...:|||||..:...||:  |..:.|...|     ::.||.|:|||..||..| |
 Worm   125 NDT-------YPVIVFIHGGRFQTGSGS--DIPQRAILSNFVSRKIVFVTFNYRLGPLGFAST-G 179

  Fly   361 KESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLV 425
            .....||.||.|.:..|.|:|.|...|||||.:|.|:|:||||..|::|.:||.|..|.|:.:|:
 Worm   180 DSVLPGNIGLWDQIWALKWVKANAEVFGGDPSNILLMGHGTGAASASLLALSPRAEGLFQKVLLM 244

  Fly   426 SGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVKVDHPRFLVGFAPF 490
            |||||.|..::...:.....:.::.||.. ....:|..|.|.:|..|:...|..|......|.|.
 Worm   245 SGSALQPGVVRNTQVNATWNMNDRFGCRA-FNSSELLDCARKRSKEEIFQYKRLHFDDYEEFVPI 308

  Fly   491 VDGT-VISPGANPLGSTTL-----PLGSAIVST----SGIEYANFPKRDLIFCLTSVESYLDLSA 545
            :||. .|.|  .|....||     |:   ::.|    |.:......::||.|...:.|:...| |
 Worm   309 IDGVGGILP--EPPEQLTLHRRKTPI---VIGTTKDESSLRILLLNEKDLNFSSITWENGETL-A 367

  Fly   546 QDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDW--------EKAIRNPLSSRDATL 602
            .:|..||.:.:..|:               |....|:||. |        |..:.|.|      |
 Worm   368 DNLTLGFKQFQNHRL---------------ISQGCKSEYV-WTQVDPSFPESVLFNSL------L 410

  Fly   603 QFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPMSPLFP 667
            :..|.....:|..:|...:.......|...|.|  |.|.:.....:..|.|......  ::|.|.
 Worm   411 KMYSHFWYDAPASQLATYYLKHDLPVYLYSFDH--ISENFYDIDRAFHGVDKLHIFN--VTPRFL 471

  Fly   668 H-----NYTTQERQIGRLMLRYLSNFAKTGNP-----------NQSTAKSVLPNPNEVLETALHQ 716
            :     |:...:|.: .:....::|||..|.|           ..:|||
 Worm   472 NKRKDMNWQLDQRVV-EIFSELVANFALYGTPTHENDGFSFNWTSTTAK---------------- 519

  Fly   717 QKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSY 779
                  .|::.:::::.::.|.|..:.    |...::..|.|.:.|....|.....:||||::
 Worm   520 ------ELSYLSITDSPSMQVGYRWQG----HVFWNWYARSLDAVDVGNIQRIAQLDRDVGNW 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	160/579 (28%)
cest-19	NP_509187.4	Abhydrolase	27..544	CDD:389770	162/608 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810