Protein Alignment Nlg2 and cest-16

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_741812.2
• Gene: cest-16 / 180905
• WormBaseID: WBGene00020330
• Length: 697
• Species: Caenorhabditis elegans
• Alignment Length: 777
• Identity: 177/777 - (22%)
• Similarity: 292/777 - (37%)
• Gaps: 235/777 - (30%)

  Fly   163 VLLLLTSLWPDCCECLHGGSNTVKTKYGLLRGIVVR-SSPLVEAFLGIPYASPPVGSLRFMPPIT 226
            :|||||.::......|...|.:|..:.||:||.:.. ....::.|.|:|||.||:|.|||.||:.
 Worm     4 LLLLLTFIFSWANGQLLEKSRSVWVEQGLVRGNIYNIDGKHIQIFRGVPYAEPPIGELRFKPPVK 68

  Fly   227 PSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPY 291
            .:.|.....|..:.|.|.|.:....|...|...:.|               |||||||||::.||
 Worm    69 KTRWHQELPAVEYGPPCLQFMDFHKNDKFAKTNMDR---------------QSEDCLYLNVFSPY 118

  Fly   292 ETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVI-----VVTINFRLG 351
            :       |||   |.|| ...:|:|||.|:...|.:.....|:.| .|::     .|:||:|||
 Worm   119 D-------TDD---ESKT-YPILVWIHGGSFLAGSADTGIDMEVIA-ANIVSKGIAFVSINYRLG 171

  Fly   352 IFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVAS 416
            ..||:.....:..:||||:.|:|..|.|::.|:..|.|||..:|::|...|...:::|.:||..|
 Worm   172 PLGFMNYQNGDKLEGNFGIWDMVMALQWIQSNIKQFNGDPTKVTVMGESAGGAASSLLALSPKTS 236

  Fly   417 DLIQRTVLVSGSALSPWAIQKN--PLF-VKRRVA--------------EQTG------------- 451
            .|:.:.:::|||:::.|||.::  |.: |...||              |..|
 Worm   237 GLLHQAIIMSGSSMAGWAIHRHSQPAYSVDNLVAYFRCEKWINEDDTKEVVGDEYQHLTHSVIRS 301

  Fly   452 --CH----------GDMLYDDLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLG 504
              |:          .||...|...|||.:       :....|.|....|.            .||
 Worm   302 ALCNYQNVKINCLTDDMTQMDKMNCLRKE-------LNFSSPLFRKALAA------------ELG 347

  Fly   505 STTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQDLEFG------FNETRRDRILRT 563
            .:.:.:...:|.:||:.......|  |..:|.|..        .|:|      :|..:||.:.|:
 Worm   348 VSKMVVDGDLVPSSGVSLVRNNAR--IPIMTGVAR--------KEWGHKKAMFYNMHQRDGLKRS 402

  Fly   564 FVRNNFHYHLNEIFAVLKNEY--TDWEKAIRNPLS-SRDATL---------QFLSDGHTASPLIK 616
            .|.       .:::.::.|.:  |..||...:.:. ..:||:         :|::| .....|.|
 Worm   403 DVE-------EQVYRIIDNSFHETASEKLANSTVQLIANATIVRYLETPNNEFIAD-QVVGALQK 459

  Fly   617 LG-----------------------YMHS---------LRGGRAYFLHFKHKTIEEEYPQRS--- 646
            |.                       |::|         |...|..:..|..|.:|.:..::|
 Worm   460 LESDIEFVAPCEREVAAYVDKGVPVYLYSFDYVPKSPILESERKIYSLFGTKPVEMKRTEKSEIL 524

  Fly   647 --GSVRGEDVPFWLGLPMSPLFPHN-YTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNE 708
              .:..|.|..|......|..|..: ||.:|..:.:::...|:||.|.|:|:
 Worm   525 EKAAFHGLDHAFIFSKGYSSNFEISPYTKREETMSKILCTMLTNFVKNGDPS------------- 576

  Fly   709 VLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSE 773
                        :|..:.|..|                             .|.:.:..|.:..:
 Worm   577 ------------TTRFSWPIFS-----------------------------GNSSQYVSLDVPLK 600

  Fly   774 RDVGSYDGDELPFWDAYDVVNQLYV------------ELGNKANIQ-SHYRGHKLSMWLNLI 822
            ...|.....:..||:....:...||            :|.|:..:| |.||....::|:.:|
 Worm   601 LLEGEIHFPDAQFWNTEAELITRYVSKDSETDLDPDADLTNEERVQLSAYRRSWYALWVLVI 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	155/650 (24%)
cest-16	NP_741812.2	alpha/beta hydrolases	23..608	CDD:473884	159/702 (23%)