Protein Alignment Nlg2 and cest-2.1

DIOPT Version :9

• Sequence 1: NP_001245916.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_506508.2
• Gene: cest-2.1 / 179916
• WormBaseID: WBGene00013875
• Length: 675
• Species: Caenorhabditis elegans
• Alignment Length: 698
• Identity: 157/698 - (22%)
• Similarity: 260/698 - (37%)
• Gaps: 203/698 - (29%)

  Fly   161 LLVLLLLTSLWPDCCECLHGGSNT-VKTKYGLLRGIVVRS--SPLVE----AFLGIPYASPPVGS 218
            ||.|.||::|       ||...:| |:...|.:.|.::.|  |||..    .|||||:..||.|:
 Worm     3 LLFLFLLSTL-------LHISISTRVQLSTGTIEGKILTSTYSPLGNHTGIGFLGIPFVEPPAGN 60

  Fly   219 LRFMPPITPSTWKTVRSADRFSPVCPQNI----------PIPPNGPEALLEVPRARLAQLRRLLP 273
            |||..|..|..|..:.....:.|.|..:.          ||
 Worm    61 LRFRKPRPPIPWDGILETKEYKPACMSDAKKTYKNGVGGPI------------------------ 101

  Fly   274 LLKNQSEDCLYLNIYV-PYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAA 337
                 ||||||.|::. .|..:|:             ..|.::.:||......|.:.::...|..
 Worm   102 -----SEDCLYANVFTNQYCMKRK-------------NCSVMIVVHGGRILTESASAFNPEILVN 148

  Fly   338 H-----GNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLL 397
            :     .|::|||.|:|||.|||....| |....|.|:.|::..:.|.::.:..|||:...:|::
 Worm   149 NFVGQGRNIVVVTFNYRLGTFGFGVLNG-EKGDSNVGMFDMLEAVKWTRKEVHNFGGNKDKLTMV 212

  Fly   398 GYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFV-KRRVAEQTGCHGDML---- 457
            |:..|..|......||::..::.:.:::||:.   :.:.|...|. ...:|::.||..::.
 Worm   213 GHSAGGSLVGAFTSSPLSKGMLNQQIIMSGAL---YQMGKLANFKGMTAMAQKAGCLPEVFGFRK 274

  Fly   458 -----YDDLAPCLRTKSVAELLAVK---VDHPRFLVGFAPFVDGT-VISPGANPLGSTTL-PLGS 512
                 .|....|||..|..|:|..:   :.:..:.:. .|.:||. :::.....|.|.|: |:.|
 Worm   275 LSQVRIDKTYSCLRNISAQEVLDAQLWVLQNTTYYIS-VPHIDGEFLLNYSDEILASGTIHPINS 338

  Fly   513 AIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIF 577
            .|.:|:.      ..||.|:            ..||:   |..:::.:|:... .:..|.|
 Worm   339 MIGTTTA------ELRDPIY------------INDLK---NADKKEELLKNLC-EHIGYEL---- 377

  Fly   578 AVLKNEYTDWEKAIRNPL----SSRDATLQFLSDG---HTASPLIKLGYMHSLRGGRAYFLHFKH 635
                  ||:.|:..|...    :..||  |||:|.   :..|  ||:...|:.:..:.:...:.:
 Worm   378 ------YTEPEEFSRKCQKFYGNGDDA--QFLADDMEFYDGS--IKVANAHASKNTKVFMYSYDY 432

  Fly   636 KTIE---EEYPQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQS 697
            |...   ::|.|.......||:.:..|....     |:|.::..|.::.....::|...|||:.|
 Worm   433 KDAGPAFKKYAQAPPPHHSEDLIYVFGTSRG-----NFTEKDYVIEQIYSGMFADFVNFGNPSPS 492

  Fly   698 TAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSND 762
                             .:||.:..|                        .|||.|.   |...|
 Worm   493 -----------------KEQKWKEYS------------------------PEKREYF---LIDFD 513

  Fly   763 AAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHY 810
            ..||..|   .||  .|....|.||..          .|.| :...||
 Worm   514 KNFTMPG---TRD--GYYSRALEFWST----------AGTK-SFSEHY 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	127/577 (22%)
cest-2.1	NP_506508.2	COesterase	21..533	CDD:365897	142/648 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810