DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and cest-1.1

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_506506.1	Gene:	cest-1.1 / 179915	WormBaseID:	WBGene00011362	Length:	673	Species:	Caenorhabditis elegans

Alignment Length:	803	Identity:	164/803 - (20%)
Similarity:	289/803 - (35%)	Gaps:	233/803 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LLLLTSLWPDCCECLHGGSNTVKTKYGLLRGIVVRSSPL----VEAFLGIPYASPPVGSLRFMPP 224
            :|||..::  .|:.:...|.|::.|.     :.:..|||    ...|||||:..||:|.||:..|
Worm     7 VLLLIQMY--VCKRVQLSSGTIEGKI-----LNISYSPLGNQSATVFLGIPFVEPPIGDLRYRKP 64

  Fly   225 ITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQ-----SEDCLY 284
            ..|.:|:.|...:.:...|..|                        .....||:     ||||||
Worm    65 RPPKSWEGVLVTNEYKSACMSN------------------------ATKTYKNKFGGPISEDCLY 105

  Fly   285 LNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDG----SELAAHG-NVIVV 344
            ||:.           |::...|.| ..|.::.:||..|...|.:.::.    :.....| |::||
Worm   106 LNVL-----------TNEYCLENK-NCSVMMIVHGGGYLTESASTFNPEILINNFVGQGRNIVVV 158

  Fly   345 TINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANIL 409
            |.|:|||:|.|.:..| :....||||.|::..::|::..:..|||:...|||.|:..||.:....
Worm   159 TFNYRLGLFSFGQFNG-DRGDKNFGLYDMIESVNWVRREIENFGGNKNRITLAGHSAGASMIVAF 222

  Fly   410 VVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRV-AEQTGCHGDML---------YDDLAPC 464
            ..||:...|:.:.:::|....:   :.|...|....| |:..||..:.:         .::...|
Worm   223 TSSPLTKGLVHQQIIMSAPMTN---MSKKSNFKGMTVMAQMVGCLSEEIGFNKLSEEQVENTYSC 284

  Fly   465 LRTKSVAELLAVK---VDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFP 526
            ||.||..::|..:   :.:..:.:|..|..:..:.....|...|.::...:.::.|:.:|
Worm   285 LRKKSAQQILDAQLWLLQNSTYFLGAPPIDEHFLTDYPENLYASKSIYPINTLIGTTTLE----- 344

  Fly   527 KRDLIFCLTSVESY-LDLSAQDLEFGFNETRRDRI-------LRTFVRNNFHYHLNEIFAV-LKN 582
                    ....|| :|.:..|.:....|...|.|       ..||.:.....::|...:: |.|
Worm   345 --------VEESSYIIDPAFADKKVELLENLCDHIGYVLYEEPETFSKKCQKQYMNGNSSMNLSN 401

  Fly   583 EYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRG-GRAYFLHFKHKTIEEEYPQRS 646
            |...:..||.            .:|.||:.......|.:..|| |.||     .:.:|...|..|
Worm   402 EMEFYTPAID------------FADSHTSGNTKVFLYSYDYRGAGPAY-----DRYLEVRSPHHS 449

  Fly   647 GSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNP--------NQSTAKS-- 701
                 ||:.:..|.......|.:|..::...|     ..::|....||        ||.|.::
Worm   450 -----EDLIYVFGTHRGIFAPKDYIIEKIYSG-----MFADFVNFENPLPSGDQKWNQYTKENRE 504

  Fly   702 ----------VLPNPNEVLETALHQ-----QKKRSTSLTHPNLSE---ALNLAVLYNQRRSNAMH 748
                      :.|...:...|..::     .||.......|:|..   ||.::.|.
Worm   505 HFLINFDKNFITPGMRDNYYTEAYEFWSTVGKKSFKEEWSPSLDTFTCALVISPLV--------- 560

  Fly   749 EKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGH 813
               |::::...:.|..|.|..:                         ||.|..|....:...|..
Worm   561 ---SHMKQTTTAFDKTFEQTEL-------------------------LYKEEVNFLKREKLERTQ 597

  Fly   814 KLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTKPAEDD----------- 867
            :|.|      :..|    .|:::|....::.:.|:::.||         ..||:
Worm   598 ELKM------ETKR----RDKALRIQNRKNGLANKEITEG---------DEEDESSKLDILLIIS 643

  Fly   868 --------------NIIIMQRSR 876
                          |:|:.:|:|
Worm   644 AGTLFGGILYVTLPNVILQKRAR 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	129/586 (22%)
cest-1.1	NP_506506.1	COesterase	19..531	CDD:278561	130/596 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810