Protein Alignment Nlg2 and cest-1.2

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_506504.2
• Gene: cest-1.2 / 179914
• WormBaseID: WBGene00011364
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 612
• Identity: 149/612 - (24%)
• Similarity: 232/612 - (37%)
• Gaps: 165/612 - (26%)

  Fly   182 SNTVKTKYGLLRGIVVRS--SPL----VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFS 240
            |..|:...|::.|..:.|  ||.    ..|||||||..||:|.|||..|....||..|....:|.
 Worm    18 STKVQLSTGIIEGKQLNSTYSPFGNQSAIAFLGIPYVEPPIGDLRFRKPRPQKTWSGVLETKKFK 82

  Fly   241 PVCPQNI-----------PIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETR 294
            |.|..|.           ||                             ||||||||:.
 Worm    83 PACMSNSTKTYKNGGIGGPI-----------------------------SEDCLYLNVL------ 112

  Fly   295 RQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAH-----GNVIVVTINFRLGIFG 354
                 |:....|.| ..|.|:.:||..|.:.|...::...|..:     .|::|||||:||||||
 Worm   113 -----TNQYCLENK-NCSVVIIVHGGGYLFESAATFNHEILVNNFVGQDRNIVVVTINYRLGIFG 171

  Fly   355 FLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLI 419
            |....|.|..: |.|:.|.:..:.|::..:..|||:...|||.|:..||.:.....:||:...||
 Worm   172 FGHLNGFEGDK-NVGIFDTLEAVKWVRREIKQFGGNKDRITLAGHSAGAGVVAAFTISPLTKGLI 235

  Fly   420 QRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHG-------------DMLYDDLAPCLRTKSVA 471
            .:.:::||...:  ..:|:.......:||:.|||.             :.:|.    |||.|...
 Worm   236 HQQIVMSGPMTN--MSKKSNFKGMTAMAERVGCHSKKYGFNKLPEHEVEQVYS----CLRKKPAQ 294

  Fly   472 ELLAVK---VDHPRFLVGFAPFVDGTVISPGANP-------------LGSTTLPL-GSAIVSTSG 519
            |||..:   :.:..|..| ||.|||..|:...:.             ||:||..| .:..:|.|
 Worm   295 ELLDAQLWLLQNSTFYFG-APPVDGEFITDYPDNLYSEKSIFSINTLLGTTTRELQDTGYISNS- 357

  Fly   520 IEYANFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEY 584
             .|:.|                            ||:     .||::|.......||:...::..
 Worm   358 -NYSKF----------------------------ETK-----ETFLKNLCDQIGIEIYKESEDFS 388

  Fly   585 TDWEKAIRNPLSSRDAT--LQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKH--------KTIE 639
            :..:|...|...|:..:  ::|.:..      |.|...|:.:|.:.|...:.:        |.::
 Worm   389 SKCQKWYINGSDSKSLSDDMEFYTQA------INLADAHARKGKKVYMYSYAYSGAGPAFKKYMK 447

  Fly   640 EEYPQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLP 704
            .:.|..|     ||:.:..|.......|.:|..:....|     ..::|....:|:.||.:..|.
 Worm   448 VKSPHHS-----EDLIYTFGTHRGVFAPKDYVIEYIYSG-----MFADFINFEDPSPSTDQPWLQ 502

  Fly   705 NPNEVLETALHQQKKRSTSLTHPNLSE 731
            ...|..|..|....:   :||.|.:.:
 Worm   503 YTKENKEYFLVDFDQ---NLTMPGMKK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	149/608 (25%)
cest-1.2	NP_506504.2	COesterase	18..536	CDD:395084	149/612 (24%)