DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and cest-32

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_504397.1	Gene:	cest-32 / 178909	WormBaseID:	WBGene00016862	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	137/557 - (24%)
Similarity:	235/557 - (42%)	Gaps:	104/557 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 LTSLWPDC-CECLHGGSNTVKTKYGLLRGIVVRSSPLVEAFLGIPYASPPVGSLRFMPPITPSTW 230
            |:.|.|:. .|.|:.....|      :..|......:|..:||||:|..|:..|||..|:....|
Worm     5 LSHLKPEASLEVLNASCGPV------IGNIYRHDDKIVNGYLGIPFAKAPICELRFKKPVEAEKW 63

  Fly   231 KTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSED-CLYLNIYVPYETR 294
            ....:..::.|.|||:..:..|                 .|.|..:..:|| ||.|||:.|
Worm    64 TKPLNCHKYGPGCPQSGHMISN-----------------LLPPGYREFAEDNCLNLNIFAP---- 107

  Fly   295 RQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAH---GNVIVVTINFRLGIFGFL 356
             ..::.:...|.|     .:|:.||..::....:.:|...|:..   .:|||||.|:|:|..||:
Worm   108 -SWKSEEFPNGLP-----IMVYFHGGGFEIGFSSMFDDYSLSGTLPLKDVIVVTANYRVGPLGFM 166

  Fly   357 KTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQR 421
            .| |.|.::||:||.|....|.|::|::.:|||:|..:|:.|...|.|.|.:|.:||.::.|..|
Worm   167 TT-GDEVSRGNYGLWDQTLALKWVQEHIKSFGGNPNIVTVCGTSAGGVSAGLLALSPHSNKLFHR 230

  Fly   422 TVLVSGSALSPWAI----QKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVA---ELLAVKVD 479
            .:.:||||...::|    |:..:|  |..|:..|..|:. .:.|....:::.::   |....:..
Worm   231 FMAMSGSAFCEFSIRTKEQEAEIF--RNFAKHHGYEGED-SESLLEWYKSQPLSKFQETATFEKK 292

  Fly   480 HPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANF------PKRDLIFCLTSVE 538
            ...||. |.|..||.......:.| |...|...|:.:....|...|      .:.|:....:|..
Worm   293 ASGFLT-FIPNFDGDFFPKPFDEL-SREAPKLDAMATVDEYEGLGFLTMFQSRRNDMDIIKSSFG 355

  Fly   539 SYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQ 603
            |.:..:|.|::        .||:..:::|           :.||:    :||:...|      :|
Worm   356 SDVVENAVDVQ--------KRIMEFYMKN-----------IDKND----DKAVEKRL------IQ 391

  Fly   604 FLSDGHTASPLIKLGYMHSLR-----GGRAYFLHFKHKTIEEEYPQRS-----GSVRGEDVPFWL 658
            .:||.     ...:|.:.:::     |..||...|.:..:....|..:     .:..|.::.:.|
Worm   392 LISDS-----WFNIGALETVKTSTKYGSNAYLGSFDYYNMGSNDPYATWFPFKAANHGSELKYML 451

  Fly   659 GLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPN 695
            |..|....|   ..:|.::..:|....:||.|.||||
Worm   452 GEGMGKFSP---IEEEFKVIDMMGTLTANFVKYGNPN 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	132/541 (24%)
cest-32	NP_504397.1	COesterase	15..516	CDD:278561	134/547 (24%)
cest-32	NP_504397.1	Aes	<104..>227	CDD:223730	42/133 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810