Protein Alignment Nlg2 and cest-6

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_501070.1
• Gene: cest-6 / 177459
• WormBaseID: WBGene00020688
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 128/589 - (21%)
• Similarity: 210/589 - (35%)
• Gaps: 170/589 - (28%)

  Fly   161 LLVLLLLTSLWPDCCECLHGGSNTVKTKYGLLRGIVVRSSPLVEAFLGIPYASPPVGSLRFMPPI 225
            :.|||::.|.:..|      .:..:.|..|.:.|..:.|   .:.|..||:|.||:|.|||..|:
 Worm     8 IFVLLIVYSAYKSC------EAGVITTSLGSINGNQIGS---YQTFKKIPFAKPPIGKLRFQKPM 63

  Fly   226 TPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVP 290
            ....|:.:.:|..:.|.|..| ......|:..::                    ||||::||:
 Worm    64 AAEKWEGILNATEYGPACMSN-SSTSKSPQKWID--------------------EDCLHINIF-- 105

  Fly   291 YETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSEL---AAHGNVIVVTINFRLGI 352
                     |.||....| ..|.|.::||....::|...::...|   .:..:||:|...||||:
 Worm   106 ---------TTDTCLSSK-NCSVVFYVHGGELVYDSAVMFEDKYLFDTFSSRDVILVIPAFRLGL 160

  Fly   353 FGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVS-PVAS 416
            |.......:..|..|..|.|::..|.::|..:..|||....:|..|:..|..:.:::..| .:.:
 Worm   161 FSHFVVEDQNVAPNNLALYDILLALEFVKSEIHNFGGSSDRVTAFGHSYGGHVVSVMAFSTEINT 225

  Fly   417 DL--IQRTVLVSGSALSPW-----AIQKNPLFV-----------KRRVAEQTGCHGDMLYDDLAP 463
            ||  .||.:.:  |:::.|     .|:|...|:           |.|:   |....|..   :..
 Worm   226 DLSYFQRVICM--SSVNVWDSLEFEIEKTMRFIQYANCSVPQDLKSRM---TSFEQDSY---MME 282

  Fly   464 CLRTKSVAELLAVK-----VDHPRF--LVGFAPFVDGTVI-----SPGANP--LGSTTLPLGS-- 512
            ||:.....|||.::     ..||.:  ||...|.:...::     .|...|  .|.|...|..
 Worm   283 CLQDIDSMELLRIQRSLEDEGHPIYSGLVLREPLIQNVLVQDFYEKPKNIPTLTGCTYKELDKFH 347

  Fly   513 ---AIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLN 574
               .||.|.|  |.|:.:.|        :.|.|    |.::|              |.:.:.|.:
 Worm   348 AYHNIVETLG--YENYKECD--------DKYRD----DRKYG--------------RFDLNKHAD 384

  Fly   575 EIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIE 639
            |.|.:|.......:|.:.                               :|...||       .|
 Worm   385 ETFGILAQTKLKVDKQLD-------------------------------KGIPTYF-------YE 411

  Fly   640 EEYPQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRY---LSNFAKTGNPNQSTAKS 701
            ..||:.....  :|:.:.:|:       |.:...|.:| .|...|   ..||.|.|.|......|
 Worm   412 YSYPKHPSHT--DDLSYIMGV-------HAFEKDENEI-HLAKSYQEMFMNFVKFGEPGGGFEMS 466

  Fly   702 VLPN 705
            ...|
 Worm   467 TFEN 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	123/568 (22%)
cest-6	NP_501070.1	alpha/beta hydrolases	25..500	CDD:473884	123/566 (22%)