Protein Alignment Nlg2 and cest-4

DIOPT Version :9

• Sequence 1: NP_001245916.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_501043.1
• Gene: cest-4 / 177445
• WormBaseID: WBGene00015930
• Length: 592
• Species: Caenorhabditis elegans
• Alignment Length: 722
• Identity: 147/722 - (20%)
• Similarity: 235/722 - (32%)
• Gaps: 268/722 - (37%)

  Fly   182 SNTVKTKYGLLRGIVVRSSPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCPQN 246
            |..|.|..|.:.|..:.|..|   |..||.|.||:|.|||..|..|..|..||:|..:.|.|..|
 Worm    26 SAIVSTSLGQIDGDQIGSFHL---FKHIPLAKPPIGKLRFQKPEPPEKWTGVRNAKAYGPACISN 87

  Fly   247 IPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEPKTKL 311
            ..: ...|:..::                    ||||::||:           |.|...:.| ..
 Worm    88 SSV-STSPQKWID--------------------EDCLHINIF-----------TSDKCLKSK-DC 119

  Fly   312 STVVFIHGESYDWNSGNPYDGSELA---AHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDL 373
            :.|.:.||....::|...::.:.|.   .:.:||:....||||||.......:..|..|..|.|:
 Worm   120 AVVTYFHGGGLMYDSAVMFNDTYLLGTFVNQDVIIAIPAFRLGIFSHFVVEDQSIAPTNLALYDI 184

  Fly   374 VAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVAS---DLIQRTV-LVSGSALSPWA 434
            :.|:.::|..:..|||:.|..|::|:..|..:.|||..|...:   .|.|::: :.||.......
 Worm   185 LLGVEFVKNEIHNFGGNNQKNTIMGHSYGGSIVNILTFSSKINHDLSLFQQSICMSSGHDFETLE 249

  Fly   435 IQKNPLFVKRRVAEQTGCHGDMLYD--------DL--APCLRTKSVAELLAVK-----VDHPR-- 482
            ||   :....|.|:..||....:.:        ||  ..||:.|...|||.|:     ..:|.
 Worm   250 IQ---IQKTNRFAKHAGCTVPSIIEKKMTTRQSDLYRMKCLQNKDALELLRVQRLLEDEGYPTYG 311

  Fly   483 FLVGFAPFVDGT-----VISPGANPL--GSTTL---------PLGSAIVSTSGIE-----YANFP 526
            :||...|.:...     :.||...|:  |.|..         |:|.|:    |.|     |..|.
 Worm   312 YLVQREPLIQEIPYQEFMKSPKKIPMLTGCTRYEMDHSPAPKPIGQAL----GFENPEEVYMKFR 372

  Fly   527 KRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAI 591
            |              |...:..||| |.:...:.:...||...:..|::.......|||
 Worm   373 K--------------DWDDEVYEFG-NHSDETQAIMVQVRVRVNNLLSKNVPAYLYEYT------ 416

  Fly   592 RNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPF 656
                                                 |..|.:|.               :|:.:
 Worm   417 -------------------------------------YPKHARHT---------------DDLFY 429

  Fly   657 WLGLPMSPLFPHNYTTQERQI--GRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKK 719
            .:|:       |.:...|.:|  |::......||||.|:|
 Worm   430 LMGV-------HRFEKDENEIELGKVYETIFMNFAKFGDP------------------------- 462

  Fly   720 RSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDEL 784
                      .|...||        ||  |..||                         |:
 Worm   463 ----------KEGFELA--------NA--ENESY-------------------------YE---- 478

  Fly   785 PFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHF---------------NINDQ 834
            .:||.         |.|.:..:::.:....::.||..:.:..:|.               ...::
 Worm   479 VYWDG---------ETGERPQMKTKFEEKIINYWLKDMVEYDKHITELKNQKISIRKPVVRFYEE 534

  Fly   835 SMRHHQF 841
            |.::||:
 Worm   535 SSKYHQY 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	128/576 (22%)
cest-4	NP_501043.1	Abhydrolase	28..503	CDD:389770	140/680 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810