Protein Alignment Nlg2 and cest-5.1

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_501022.3
• Gene: cest-5.1 / 177429
• WormBaseID: WBGene00015279
• Length: 580
• Species: Caenorhabditis elegans
• Alignment Length: 670
• Identity: 148/670 - (22%)
• Similarity: 241/670 - (35%)
• Gaps: 193/670 - (28%)

  Fly   161 LLVLLLLTSLWPDCCECLHGGSNTVKTKYGLLRGIVVRSSPLVEAFLGIPYASPPVGSLRFMPPI 225
            ||:|:.:.:.         ..|..:.|.:|.|.|..:....|   |..||:|.||||:|||..|.
 Worm     6 LLLLIFIINA---------ADSLIIHTSFGHLEGAEIGDYHL---FKKIPFAKPPVGNLRFQKPE 58

  Fly   226 TPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVP 290
            ....|..:|||..:.|.|..|        .:..:.|:             |...||||::||:..
 Worm    59 AAGKWDGIRSAIEYGPACMSN--------SSKTKSPQ-------------KWVDEDCLHVNIFTS 102

  Fly   291 YETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELA---AHGNVIVVTINFRLGI 352
            .:..:.|            ..:..|:|||....::|...::.:.|.   ...:||:|...|||||
 Worm   103 KKCLKSR------------NCAIAVYIHGGGLTYDSAVMFNDTVLLDTFVKRDVILVIPGFRLGI 155

  Fly   353 FGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVAS- 416
            |.......:..|..|..|.|:...|.::|..:.:|||:.|.|||.|:..|..||:::..|...:
 Worm   156 FSHFTVHNQNVAPNNLALYDITLALEFVKSEIHSFGGNSQKITLFGHSYGGGLASMMTFSSEINR 220

  Fly   417 --DLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDM------------LYDDLAPCLRT 467
              .|.|:.:::||...  :...|:.:...:|..|...|...:            :|  :..||:.
 Worm   221 DLSLFQQAIVMSGGFY--FEELKDHIEGTKRFVEYANCSVPLKLERKMERSQQEMY--MMKCLQK 281

  Fly   468 KSVAELLAVKVDHPRFL--VGFAPFVDGTVI----------------SPGANPL--GSTTLPLGS 512
            .|..|||.::    |.|  .|:..|  |.||                ||...|:  |.|.|....
 Worm   282 LSGMELLRIQ----RLLEDKGYPDF--GGVILREPLFPDVKKFELLKSPKNIPMLTGCTNLEFDH 340

  Fly   513 AIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIF 577
            ..:.....:|..|...|     ...|.|    ..|:|.|             |.|
 Worm   341 ESIKVPFGKYLEFENPD-----ECDEKY----RNDVESG-------------VEN---------- 373

  Fly   578 AVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEY 642
               :..:||..:.|..||                    ||...:.|......:|:      |..|
 Worm   374 ---RGNHTDKTQGIILPL--------------------KLQINNLLENNVTAYLY------EYTY 409

  Fly   643 PQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQI--GRLMLRYLSNFAKTGNP---------NQ 696
            |:.....  :|:.:.:|:       |.:...|.::  .::....:.||.|.|.|         |:
 Worm   410 PKHGRHT--DDLSYIMGV-------HAFEKDENEVHLEQVYKDMVINFIKLGEPGMGFEKSEQNE 465

  Fly   697 STAKSVLPNPNEVLETALHQQKKR---STSLTHPNLSEALNLAVLYNQRRSNAMHEKRS------ 752
            ||...:..|     ||...:.:.|   ...:|...|.|.:.    ::|:.:....:.:.
 Worm   466 STYFDIYWN-----ETTGERPRMRKYFEKEVTDYWLKEMIE----FDQKVTETKKKLKQISLKTV 521

  Fly   753 -YIRRRLRSNDAAFTQLGIS 771
             :|.:.|..||.|.|.:|:|
 Worm   522 PFIEKPLEQNDEAGTLIGVS 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	134/598 (22%)
cest-5.1	NP_501022.3	alpha/beta hydrolases	17..495	CDD:473884	134/598 (22%)