Protein Alignment Nlg2 and cest-12

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_499576.4
• Gene: cest-12 / 176642
• WormBaseID: WBGene00013540
• Length: 850
• Species: Caenorhabditis elegans
• Alignment Length: 920
• Identity: 194/920 - (21%)
• Similarity: 321/920 - (34%)
• Gaps: 269/920 - (29%)

  Fly   162 LVLLLLTSLWPDCCECLHGGSN--------TVKTKYGLLRGIVVR--------SSPLVEAFLGIP 210
            |:.|.|.|.:.:.....:...|        ||....|.::|..|.        .|....||.|||
 Worm     6 LLFLTLFSAFSNVSNAQYQNQNQNQQSNYVTVSCSQGSVQGRQVNLGNDQSQLYSGQANAFTGIP 70

  Fly   211 YASPPVGSLRFMPPITPSTWK-TVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPL 274
            |...|||:||..||...:.:. |:..|..|.|.|||   :...||
 Worm    71 YCQAPVGNLRLQPPQPLNQFNTTLHDATYFRPKCPQ---LNAGGP-------------------- 112

  Fly   275 LKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSG---NPYDG--SE 334
               .:|||||||:|.|     |..||:       ..||.:|.|.|.:...|.|   |...|  |.
 Worm   113 ---TNEDCLYLNVYTP-----QAGNTN-------ANLSVLVLIDGSNGFSNGGCDQNQEKGIISN 162

  Fly   335 LAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGY 399
            |... .::|||:.:|:|..||..| ...|.|.|.|::|.|..:.|:|..:..|||:|..||:.|.
 Worm   163 LVQR-QIVVVTMQYRIGALGFFTT-YTNSVQSNLGMLDQVQAMRWIKTEIVNFGGNPNQITVAGQ 225

  Fly   400 GTGAVLANILVVSPVASDLIQRTVLVSGSALSPW----AIQKNP---LFVKRRVAEQTGC----- 452
            ..||...:...:||::.:|..:.::.|||..|.:    |:..||   :...|.:.:|:..
 Worm   226 DDGACAVSAHCLSPMSQNLFNQAIVQSGSVYSCYNPTPAVPTNPQVQVTTPRPMYDQSNTGYGNA 290

  Fly   453 --------------------HGDMLYDD----LAPCL-----------RTKSVAELLA-VKVDHP 481
                                ..:..|||    ||..|           :|:::...:. ..||
 Worm   291 GYQNNYGYQPQPITSTSSYNSANAQYDDPSQQLAQTLCNISPDQWNNGQTQNIQNCMKNYTVD-- 353

  Fly   482 RFLVGFAP--------FVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVE 538
             |.|...|        .|..|...||:....:|..|....|:.|...|.|     |..|.|.:..
 Worm   354 -FFVNQQPGGPNATWMIVRDTSFLPGSIDSLTTRRPNIPIIIGTVQDEDA-----DYAFKLINTG 412

  Fly   539 SYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQ 603
            ...|.:..| ::.|:..|::::.:|        ..|::..::.|.|    ......|..:.|.:.
 Worm   413 KGSDPNNLD-DWIFDFARKNKLNQT--------QANQVSNIISNNY----GVNTGALGQQGAQVN 464

  Fly   604 FLSDGHTASPLIKLGYMHSL-----------RGGR------AYF---LHFKHKTIEEEYPQRSGS 648
            ....|......:...|.::.           :||:      ||:   :..:..|.:.:...:.|.
 Worm   465 SQYQGSGTGQQVNNQYQNTQGQQTNNQYQYDQGGQQTNNQGAYYGGVVAGQQTTYQNQNQNQQGV 529

  Fly   649 VRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGN-----PNQSTAKSVLPNPNE 708
            .|.:.           .:.:.|:.|.:|:......|.....:..|     .||....|...|.|:
 Worm   530 QRDQG-----------SYQNQYSNQNQQVYNNPGSYQQQQQQQSNNQQVYSNQGNTYSQTNNQNQ 583

  Fly   709 VLETALHQQKKRSTSL------THPNLSEALNLAVLYNQRR------------------------ 743
            ...:..:|.:.:.||.      .:.|:::..|:...|..:|
 Worm   584 YGSSGQNQNQNQQTSNQYQNNGVYTNVTQYSNVNNNYGYQRDQPATTGMQTVNGNGNGVTDFSQL 648

  Fly   744 ----SNAMHEKRSYIRRRLRS---NDA------AFT---QLGISSERDVGS-----YDGDELPF- 786
                |.|..:..|....:::|   |.|      .||   ::|.::..|.|:     :.|.::.|
 Worm   649 RTISSIASDQSTSLTTTQIQSYMQNGARHVRVYQFTHVSEVGRNTVPDTGANWKPVFKGQDMYFI 713

  Fly   787 ------W-------DAYDVVNQL------YVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNIN 832
                  |       ....|.||:      :|:.||.||            |.....|.:.:.|:|
 Worm   714 TMSETIWTNSNYTPQDRQVANQMGQRWSDFVKTGNVAN------------WDTTNQQNYNYCNLN 766

  Fly   833 DQSMRHHQFQDDMNNRDLYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPP-----SKNPSTNAT 892
            .|:.:..|:  ....|.:::..|.|.::..    .|...|..:::...|..     |:.|.|...
 Worm   767 TQATQQAQY--GQQARRVFQDQVNPIVRIA----QNNYAMANNQSIPYPSASGSQISRAPGTAQA 825

  Fly   893 QALNPLGTGT 902
            |..|....|:
 Worm   826 QYTNNANGGS 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	146/655 (22%)
cest-12	NP_499576.4	alpha/beta hydrolases	40..>400	CDD:473884	106/402 (26%)
		alpha/beta hydrolases	<678..774	CDD:473884	21/107 (20%)