DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and cest-25

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_497609.1	Gene:	cest-25 / 175390	WormBaseID:	WBGene00022178	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	631	Identity:	160/631 - (25%)
Similarity:	237/631 - (37%)	Gaps:	182/631 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 SNTVKTKYGLLRG--IVVRSSPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCP 244
            |..|.|.||.:.|  ::......|:||.|||||:||:|:|||..|.....|..||....|.
Worm    16 SRQVLTSYGPIEGRRLIHEGEKQVDAFQGIPYAAPPIGNLRFALPQPHEKWTEVRETKSFG---- 76

  Fly   245 QNIPIPPNGPEALLEVPRARLAQLRRLL-PLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEPK 308
                              ||..|...:| |....||||.|.|||:.|..|.:      :.||.|
Worm    77 ------------------ARGIQKDHVLSPKTSPQSEDNLTLNIFTPVWTPK------NETGFP- 116

  Fly   309 TKLSTVVFIHGESYDWNSGNPYDGSELAAH---GNVIVVTINFRLGIFGFLKTGGKESAQGNFGL 370
                .:::|||..:..:|.:.|....:..|   .:|:||||.:|||..||..| |..|...|..|
Worm   117 ----VILYIHGGGFVSDSAHKYGDMSICQHLVTKDVVVVTIQYRLGFLGFWTT-GDSSIPDNVAL 176

  Fly   371 MDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAI 435
            .|:|..|.|:|||:..|.|||.:|||:|...|....:.|.:|||:.||.|:.:.:.|:|...|||
Worm   177 HDMVFALKWVKENIGLFNGDPNNITLMGQSAGGASVDFLSISPVSRDLFQKVIPMGGNASCSWAI 241

  Fly   436 QKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRT------KSVAELLAV--KVDHPRFLVGFAPFVD 492
            ...||...|..|::.|....|...|....||.      .|...:.||  |.| |..|:|  |..|
Worm   242 HPRPLNACRNRAQEIGVFDGMNTLDWVEKLRELPADKFASALNMEAVDTKTD-PELLIG--PKYD 303

  Fly   493 GTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRR 557
            ...|......|.... |:...::..:..|       .|:|..               ||.|
Worm   304 NLFIPRPVMELRKEA-PMKPRLLGCAKSE-------GLVFAF---------------FGLN---- 341

  Fly   558 DRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHS 622
                   .::..|....::.|:|.      ||..  ||.:||...:.|      ..||::|..||
Worm   342 -------TKHPLHAVQQDVSAILS------EKLF--PLKARDYQEKAL------EKLIEIGTDHS 385

  Fly   623 LRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGL-----------PMSPLFPH-------- 668
                            :||:.:....::|:.. ..:|:           |.:|::.:
Worm   386 ----------------KEEWQRAMVDLKGDSF-LNVGIQQNVLDVLETQPSTPIYMYSFDYCNPK 433

  Fly   669 --------------------------------NYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKS 701
                                            ::..::.::..:..|..:||||.||||
Worm   434 AYGIMGFKLPFKDATHCTDISYVVGNHIVNSFDFNEEDYKMIEITTRLWTNFAKYGNPN------ 492

  Fly   702 VLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAV----LYNQRR 743
                 .|..:.|..::|....::..|....||.|..    :|.|.|
Worm   493 -----GEGDDVAHLEEKWEPATIESPQTHMALTLQPKLHHVYKQGR 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	151/594 (25%)
cest-25	NP_497609.1	COesterase	18..536	CDD:365897	159/629 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810