Protein Alignment Nlg2 and Nlgn3

DIOPT Version :9

• Sequence 1: NP_001245916.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_599163.2
• Gene: Nlgn3 / 171297
• RGDID: 621119
• Length: 848
• Species: Rattus norvegicus
• Alignment Length: 908
• Identity: 267/908 - (29%)
• Similarity: 400/908 - (44%)
• Gaps: 226/908 - (24%)

  Fly   184 TVKTKYGLLRGIVVRSSPL-------VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSP 241
            ||.|.:|.|||..|   ||       |:.:||:|||:||:|..||:||..|.:|..:|:|..|.|
  Rat    43 TVNTHFGKLRGARV---PLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPP 104

  Fly   242 VCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYE-------------- 292
            ||||||....  ||.:|  |....|.|..:...::..:|||||||:|||.|
  Rat   105 VCPQNIHTAV--PEVML--PVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPN 165

  Fly   293 ----------TRRQRRNTDDTTGEPKTKL------STVVFIHGESYDWNSGNPYDGSELAAHGNV 341
                      .::|..:..|..|:....:      ..:|:|||.||...:||..|||.||::|||
  Rat   166 KKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNV 230

  Fly   342 IVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLA 406
            ||:|:|:|:|:.|||.| |.::|:||:||:|.:..|.|:.||:..|||||:.||:.|.|.||...
  Rat   231 IVITLNYRVGVLGFLST-GDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCV 294

  Fly   407 NILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYD--DLAPCLRTKS 469
            ::|.:|..:..|.||.::.||||||.||:...|:.....:|::.||:   :.|  |:..|||.||
  Rat   295 SLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCN---VLDTVDMVDCLRQKS 356

  Fly   470 VAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCL 534
            ..||:...:...|:.|.|.|.:||.||            |....|:...| |:.|:   |::..:
  Rat   357 AKELVEQDIQPARYHVAFGPVIDGDVI------------PDDPEILMEQG-EFLNY---DIMLGV 405

  Fly   535 TSVE--SYLDLSAQDLEFGFNETRRDRILRTFVRNNFHY-----HLNEIFAVLKNEYTDWEKAIR 592
            ...|  .::: ...|.|.|.:.|..|..:..||.|.:.|     .|.|   .:|..||||  |.|
  Rat   406 NQGEGLKFVE-GVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDW--ADR 464

  Fly   593 -NPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPF 656
             ||.:.|...:...:|.....|.:....:|:..|...||..|.|.......|..|.:..|::||:
  Rat   465 DNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPY 529

  Fly   657 WLGLPM---SPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQK 718
            ..|:||   :.|||.|::..:..:..:::.|.:||||||:||:       |.|.:
  Rat   530 VFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNK-------PVPQD---------- 577

  Fly   719 KRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDE 783
                                     :..:|.|.:      |..:.|
  Rat   578 -------------------------TKFIHTKAN------RFEEVA------------------- 592

  Fly   784 LPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNR 848
               |..|:..:|||:.:|.|..::.|||..|::.|.:|:|.|   :|::|  |.|:
  Rat   593 ---WSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHL---YNLHD--MFHY--------- 640

  Fly   849 DLYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPSTNATQALNPLGTGTPTTTECGIDGA 913
                                     .|.||..|||....|::.|:  .|.|. |.:|....|..|
  Rat   641 -------------------------TSTTTKVPPPDTTHSSHITR--RPNGK-TWSTKRPAISPA 677

  Fly   914 MSVSELTTTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGC 978
            .| :|........|...|.:.||..:|                         |:|.|..|:|||.
  Rat   678 YS-NENAPGSWNGDQDAGPLLVENPRD-------------------------YSTELSVTIAVGA 716

  Fly   979 FLLILNVLIFAGIYHQREKRARDAKTKEELQEGDNSKNSSIL---KLNALMGG--GGACGSGP 1036
            .||.||||.||.:|::::||.::...:...|.|..:......   :|.||..|  ...|.:||
  Rat   717 SLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGTGAPELGTAPEEELAALQLGPTHHECEAGP 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	196/577 (34%)
Nlgn3	NP_599163.2	COesterase	40..624	CDD:395084	211/683 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..195		3/25 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..691		14/49 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	359	1.000	Domainoid score	I933
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	442	1.000	Inparanoid score	I1599
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9080
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.930