Protein Alignment Nlg2 and Ces1c

DIOPT Version :9

• Sequence 1: NP_001245916.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_031980.2
• Gene: Ces1c / 13884
• MGIID: 95420
• Length: 554
• Species: Mus musculus
• Alignment Length: 661
• Identity: 162/661 - (24%)
• Similarity: 272/661 - (41%)
• Gaps: 149/661 - (22%)

  Fly   169 SLWPDCCECLHGGSNTVKTKYGLLRGIVVRSSPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTV 233
            ||.|...:...|   .|..||..|.|.   ..| |..|||:|:|.||:|||||.||.....|..|
Mouse    20 SLLPPVVDTTQG---KVLGKYISLEGF---EQP-VAVFLGVPFAKPPLGSLRFAPPQPAEPWSFV 77

  Fly   234 RSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRR 298
            ::|..:.|:|.|:        ....::.....:..:.:|||  ..||||||||||.|.:..:
Mouse    78 KNATSYPPMCSQD--------AGWAKILSDMFSTEKEILPL--KISEDCLYLNIYSPADLTK--- 129

  Fly   299 NTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKES 363
                     .::|..:|:|||........:||:|..|:||.||:||||.:||||:|...| |.|.
Mouse   130 ---------SSQLPVMVWIHGGGLVIGGASPYNGLALSAHENVVVVTIQYRLGIWGLFST-GDEH 184

  Fly   364 AQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGS 428
            :.||:..:|.:|.|.|:::|:..|||:|.|:|:.|..:|.:..::||:||:..||..|.:..||.
Mouse   185 SPGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGV 249

  Fly   429 ALSPWAIQKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDG 493
            .::....:||...|...:|..:.|: |.....:..|||.|:.:|||.:.....::.:..:..:||
Mouse   250 VINTNVGKKNIQAVNEIIATLSQCN-DTSSAAMVQCLRQKTESELLEISGKLVQYNISLSTMIDG 313

  Fly   494 TVISPGANPLGSTTLPLGSAIVSTSGIEY-ANFPKRDLIFCLTSVESYLDLSAQDL--EFGFNET 555
            .|:......:        .|..|.:.:.| ..|.|::..:       .:.:..|:|  |...||.
Mouse   314 VVLPKAPEEI--------LAEKSFNTVPYIVGFNKQEFGW-------IIPMMLQNLLPEGKMNEE 363

  Fly   556 RRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYM 620
            ....:||     .||..||...:::......:.:.:.:|....:..|....|.....|.:.|.
Mouse   364 TASLLLR-----RFHSELNISESMIPAVIEQYLRGVDDPAKKSELILDMFGDIFFGIPAVLLS-- 421

  Fly   621 HSLR--GGRAYFLHFKHKT--IEEEYPQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLM 681
            .|||  |...|...|:::.  :.::.||......|:::.|..|   :||.....:.:|..:.:::
Mouse   422 RSLRDAGVSTYMYEFRYRPSFVSDKRPQTVEGDHGDEIFFVFG---APLLKEGASEEETNLSKMV 483

  Fly   682 LRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNA 746
            :::.:|||:.||||
Mouse   484 MKFWANFARNGNPN--------------------------------------------------- 497

  Fly   747 MHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYR 811
                                              |:.||.|..|| ..:.|:::|.........:
Mouse   498 ----------------------------------GEGLPHWPEYD-EQEGYLQIGATTQQAQRLK 527

  Fly   812 GHKLSMWLNLI 822
            ..:::.|..|:
Mouse   528 AEEVAFWTELL 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	148/536 (28%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	157/641 (24%)
		Aes	<121..>234	CDD:223730	45/125 (36%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810