Protein Alignment Nlg2 and LOC1280747

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: XP_061513099.1
• Gene: LOC1280747 / 1280747
• VectorBaseID: AGAMI1_007562
• Length: 1118
• Species: Anopheles gambiae
• Alignment Length: 1275
• Identity: 410/1275 - (32%)
• Similarity: 585/1275 - (45%)
• Gaps: 327/1275 - (25%)

  Fly   138 PRRRHLHYPGHSAVQPGHPE------ACALLVL----------LLLTSLWPDCCECLHG------ 180
            |:|.:.|  .....|...||      :||..||          :.|..||   |.|...
Mosquito     7 PKRSYRH--DRQQQQQPEPEVSSRVTSCAGFVLQTKLVPARATIWLWVLW---CACSFAVAPARA 66

  Fly   181 ----GSNTVKTKYGLLRGIV--VRSSPL--VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSAD 237
                .|..|.||.|.:||::  :.|..|  ||.|..:|||:||:|||||.||.....||..:.||
Mosquito    67 GPRYSSRIVDTKSGAIRGVILELNSKHLEPVEVFKAVPYATPPIGSLRFEPPKKLPPWKGTKLAD 131

  Fly   238 RFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDD 302
            .|..||||:.|...|...|||.:|:.|...|:||.|||.|||||||.||||||....|..
Mosquito   132 TFGSVCPQSFPDISNRTAALLSMPKGRYQHLKRLQPLLANQSEDCLTLNIYVPGSGSRGL----- 191

  Fly   303 TTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKES--AQ 365
                 :...|...:||||:|||.||||||||.||::|:|||||:||||||.|||||....|  :.
Mosquito   192 -----EAPYSIFFYIHGEAYDWGSGNPYDGSVLASYGHVIVVTVNFRLGILGFLKTRASLSPGSG 251

  Fly   366 GNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSAL 430
            ||.||||::..|.|:::|:.:|||||:.||::|:.|||.|||:.::|.....|:||.:|:|||||
Mosquito   252 GNLGLMDIILALQWVRDNIASFGGDPKRITIVGHDTGAALANLALISKAGKGLVQRAILLSGSAL 316

  Fly   431 SPWAIQKNPLFVKRRVAEQTGCH-------GDMLYDDLAPCLRTKSVAELLAVKVDHPRFLVGFA 488
            ||||:..:|..|:..|::|..||       .....||:..|||.|.:..|:.|::...||:..:.
Mosquito   317 SPWALIPDPDAVRLEVSQQMACHLVPGRNGRKPTTDDITECLRDKPIEALMGVRLTSVRFMPSWG 381

  Fly   489 PFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYA--NFPKRDLIFCLTSVESYLDLSAQDLEFG 551
            ||                 |||..::.....:|::  .|...:|:..:|:.|||.|.||.|:::|
Mosquito   382 PF-----------------LPLEDSMDPEFAMEHSGEGFITSELMLGMTTTESYSDFSASDIQYG 429

  Fly   552 FNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIK 616
            ..|.:|:|:|||::||.|.:||||||:.::||||||:|.|::|::.||:|::.||||||.:|:||
Mosquito   430 LEEDQRNRLLRTYIRNAFTFHLNEIFSAVRNEYTDWDKPIQHPINIRDSTMEALSDGHTVAPIIK 494

  Fly   617 LGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPM---SPLFPHNYTTQERQIG 678
            :.|:|:.||.:.|..||.:::.|.|||||.|||||||:|:..|||:   .|:||.||:.|:..:.
Mosquito   495 VAYLHARRGAKTYMFHFGYQSKESEYPQRLGSVRGEDLPYIFGLPLVQGGPVFPQNYSRQDMGVN 559

  Fly   679 RLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRR 743
            ..:|.:::||.|||:||:                |.|||    .:..||:...|..
Mosquito   560 EAVLNFVTNFCKTGDPNE----------------AGHQQ----AAPLHPDYGTAKE--------- 595

  Fly   744 SNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQS 808
                       |.|.|                        |..|:.|:...|.|:.:..|..::|
Mosquito   596 -----------RTRFR------------------------LITWETYETTTQQYLSISTKPKMRS 625

  Fly   809 HYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTKPA---EDDNII 870
            ||||||:::||||||||||..: .:.|||||.|::  .....|.|.||.:..::|.   ::..|.
Mosquito   626 HYRGHKMALWLNLIPQLHRPGD-PEVSMRHHHFRE--REPHYYAGSVRAESFSRPRSLYQNGVIN 687

  Fly   871 IMQRSR-----TTTPPPPSKNPSTNATQALNPLGTGTPTTTECGIDGAMSVSELTTTQSPKDNRT 930
            ..|.||     |...|.|:..      :.|...|.|       |..|            |.|..|
Mosquito   688 DAQESRQESFGTECTPDPTMG------EVLQENGVG-------GGGG------------PGDTLT 727

  Fly   931 GIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQR 995
            .::..|.::             |||.:|..:.:.|||.||..||.|||.||:||:|||||||:||
Mosquito   728 NVLSEEEEE-------------ELLEKLANRHYYSYTAALGVTVGVGCLLLLLNMLIFAGIYYQR 779

  Fly   996 EKRARDAKTKEE----------------------------------------------------- 1007
            ::..|.::|.:.
Mosquito   780 DRTKRKSQTSQSSGTVGGSGVTSGTSASLSGSNGTPDESEIPLTSIPSPSPVKAKRTIEPPPSYA 844

  Fly  1008 ---LQEGDNSKNSSI-------LKLNALMGGGGA------CGSGPGDIADAYTLSGSVVDSKGGV 1056
               .:.|:|..::.|       ..|:..:.||.:      .||.|   ...:..:|:....:.|.
Mosquito   845 TLPKRTGNNGASTGIHHQHQHHHHLHQHLAGGSSGTKDTKLGSPP---TSTHLRTGASTLGRSGT 906

  Fly  1057 GVVFGEYSCYDEKTK-----QLKEEKLLVE---LPPSSSTGQTSLMIDNWGACST--STLDLLKT 1111
            |      |.||..|.     |.:::..|.:   .|.|::.|.|::.|....|..:  .||.....
Mosquito   907 G------SFYDSSTSSRQQHQQQQQPYLTQQVIAPHSTNVGHTAVTITPAAATVSHHQTLPRASK 965

  Fly  1112 KPGDPIEMVTYS----------ALPSVMESTSAMSSKRGSFVDTTLQFNSPQQFDYAVQS----- 1161
            .|..||...|.|          |..||:..||.:.:...:   ||...|:.|...|..||
Mosquito   966 APLPPIRSTTCSSSSASSSSGTASTSVVPLTSILVNSNST---TTNNNNNHQPHHYQQQSCEMAN 1027

  Fly  1162 --------SDQMSFKAIEDAVKAAAGHDSEITRDDDIPEPPPPPRSFLAAQQQQQQQQQQQQTGI 1218
                    |..::...:..|..|||.....        .||      ....|.|.|.........
Mosquito  1028 ATLPPQPNSSVITVDLVSSATVAAAAATGS--------SPP------TVLGQHQHQHHHHHHHAH 1078

  Fly  1219 LRQTGAGGTSTSGSASGSG----------KKRVHIQEISV 1248
            ...:|:|..:|....:|.|          ||||.|||::|
Mosquito  1079 HHASGSGSVTTGSGPAGGGPAAPGSTATLKKRVQIQEVTV 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	246/564 (44%)
LOC1280747	XP_061513099.1	None