Protein Alignment Nlg2 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 1042
• Identity: 286/1042 - (27%)
• Similarity: 424/1042 - (40%)
• Gaps: 309/1042 - (29%)

  Fly   185 VKTKYGLLRGIVVRS-------SPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPV 242
            |.|.||.:||  ||.       .|:|: |||:|||:||:|:.||.||..|::|..||:|....|.
  Rat    44 VNTAYGRVRG--VRRELNNEILGPVVQ-FLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPA 105

  Fly   243 CPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGEP 307
            ||||:    :|....:.:|......|......::||||||||||:|||.|.....:..|:.|..|
  Rat   106 CPQNL----HGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNP 166

  Fly   308 -------KTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQ 365
                   ..|...::|:||.||...:||.:|||.|||:|||||.|:|:|||:.|||.| |.::|:
  Rat   167 PDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLST-GDQAAK 230

  Fly   366 GNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSAL 430
            ||:||:|.:..|.||.||:..|||||:.||:.|.|.||...|:|::|..:..|.|:.:..||:|:
  Rat   231 GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAI 295

  Fly   431 SPWAIQKNPLFVKRRVAEQTGCHGDMLYD--DLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDG 493
            |.|::...||...|.:|.:.||..:   |  :...|||.||..||:...|...|:.:.|.|.|||
  Rat   296 SSWSVNYQPLKYTRLLAAKVGCDRE---DSTEAVECLRRKSSRELVDQDVQPARYHIAFGPVVDG 357

  Fly   494 TVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVE--SYLDLSAQDLEFGFNETR 556
            .|:            |....|:...| |:.|:   |::..:...|  .:::.||:. |.|.:.:.
  Rat   358 DVV------------PDDPEILMQQG-EFLNY---DMLIGVNQGEGLKFVEDSAES-EDGVSASA 405

  Fly   557 RDRILRTFVRNNFHYH-----LNEIFAVLKNEYTDWEKAIR-NPLSSRDATLQFLSDGHTASPLI 615
            .|..:..||.|.:.|.     |.|   .:|..||||  |.| |....|...|...:|....:|.:
  Rat   406 FDFTVSNFVDNLYGYPEGKDVLRE---TIKFMYTDW--ADRDNGEMRRKTLLALFTDHQWVAPAV 465

  Fly   616 KLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPM---SPLFPHNYTTQERQI 677
            ....:|:......||..|.|....|..|:.:.:..|:::|:..|:||   :.|||.|::..:..:
  Rat   466 ATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVML 530

  Fly   678 GRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQR 742
            ..:::.|.:||||||:|||       |.|.:.  ..:|         |.||..|.:
  Rat   531 SAVVMTYWTNFAKTGDPNQ-------PVPQDT--KFIH---------TKPNRFEEV--------- 568

  Fly   743 RSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQ 807
                                                       .|..::...:.|:.:|.|..::
  Rat   569 -------------------------------------------VWSKFNSKEKQYLHIGLKPRVR 590

  Fly   808 SHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVR-PQLQTKPAEDDNIII 871
            .:||.:|::.||.|:|.||   |:               :.:|:....| |...|:
  Rat   591 DNYRANKVAFWLELVPHLH---NL---------------HTELFTTTTRLPPYATR--------- 628

  Fly   872 MQRSRTTTPPPPSKNPSTNATQALNPLGTGTPTTTECGIDGAMSVSELTTTQSPKDNRTGIVRVE 936
                    .||.:..|.|:.|:...|..|..|   |..||    :......:.|.|:|
  Rat   629 --------WPPRTPGPGTSGTRRPPPPATLPP---ESDID----LGPRAYDRFPGDSR------- 671

  Fly   937 TQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQREKRARD 1001
                                        .|:|.|..|||||..||.||:|.||.:|::|::|
  Rat   672 ----------------------------DYSTELSVTVAVGASLLFLNILAFAALYYKRDRR--- 705

  Fly  1002 AKTKEELQEGDNSKNSSILKLNALMGGGGACGSG-PGDIADAYTLSGSVVDSKGGVGVVFGEYSC 1065
                   ||         |:...|...||: ||| ||        .|.::.:.|.
  Rat   706 -------QE---------LRCRRLSPPGGS-GSGVPG--------GGPLLPTAGR---------- 735

  Fly  1066 YDEKTKQLKEEKLLVELPPSSSTGQTSLMIDNWGACSTSTLDLLKTKPGDPIEMVTYSALPSVME 1130
                           ||||....  .||.:...|...           .||.|.:..:..|
  Rat   736 ---------------ELPPEEEL--VSLQLKRGGGVG-----------ADPAEALRPACPP---- 768

  Fly  1131 STSAMSSKRGSFVDTTLQFNSPQQFDYAVQSSDQMSFKAIEDAVKAAAGHDSEITRDDDIPEPPP 1195
                         |.||...                 :|.:|....|.|..:.:......|.|||
  Rat   769 -------------DYTLALR-----------------RAPDDVPLLAPGALTLLPSGLGPPPPPP 803

  Fly  1196 PP 1197
            ||
  Rat   804 PP 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	197/570 (35%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	206/659 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661		13/61 (21%)
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699		12/19 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735		9/32 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836		6/15 (40%)