DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg2 and ache

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	NP_571921.1	Gene:	ache / 114549	ZFINID:	ZDB-GENE-010906-1	Length:	634	Species:	Danio rerio

Alignment Length:	585	Identity:	174/585 - (29%)
Similarity:	246/585 - (42%)	Gaps:	98/585 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 LLVLLLLTSLWPDCCECLHGGSNTVKTKYGLLRG--IVVRSSPLVEAFLGIPYASPPVGSLRFMP 223
            ||..:|||.|:.:|..... ....|.|:.|.::|  :.|.....|.||||||||.||:|..||..
Zfish     8 LLPTVLLTFLFHNCFAQAE-PDLVVATRLGRVQGTRLPVPDRSHVIAFLGIPYAEPPIGKRRFKR 71

  Fly   224 PITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIY 288
            ......|..|..|..||..|.|.:.....|      .|...:....|::      ||||||||::
Zfish    72 AEPKKPWNNVFEAKEFSNACYQFVDTSYPG------FPGIEMWNPNRVM------SEDCLYLNVW 124

  Fly   289 VPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSG--NPYDGSELAAHGNVIVVTINFRLG 351
            ||...|.|             .|:.:|:|:|..:...|.  :.|||..||....|:||::|:|:|
Zfish   125 VPPTPRPQ-------------NLTVMVWIYGGGFYSGSSSLDVYDGRYLAYTEKVVVVSMNYRVG 176

  Fly   352 IFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVAS 416
            .||||...|...|.||.||.|....|.|::||:..|||:|:.:|:.|...||....:.|:||.:.
Zfish   177 AFGFLALNGSSDAPGNVGLYDQRLALQWVQENIHFFGGNPKQVTIFGESAGAASVGMHVLSPDSR 241

  Fly   417 DLIQRTVLVSGSALSPWAIQKNPLFVKR--RVAEQTGC--HGDMLYDDLAPCLRTKSVAELL--- 474
            .|..|.:|.||...:|||........:|  ::.:..||  ..|   .:|..|||.|...||:
Zfish   242 PLFTRAILQSGVPNTPWATVTFDEARRRTTKLGKLVGCTWGND---TELIDCLRNKHPQELIDQE 303

  Fly   475 -AVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVE 538
             .|......|...|.|.||| |..|..          ..|::|:...:|...    |:.......
Zfish   304 WQVLPWSSLFRFSFVPVVDG-VFFPDT----------PDAMISSGNFKYTQI----LLGVNQDEG 353

  Fly   539 SYLDLSAQDLEFGFNETRRDRILRTFVRNNFHY---HLNEI--FAVLKNEYTDWEKAIRNPLSSR 598
            ||..|....   ||::.....|.|.....:...   |.|:|  .||:. :||||... .|...:|
Zfish   354 SYFLLYGAP---GFSKDNESLISREDFLESVKMGVPHANDIGLEAVIL-QYTDWMDE-NNGQKNR 413

  Fly   599 DATLQFLSDGHTASPLIKL------------------------------GYMHSLRGGRAYFLHF 633
            ||....:.|.:...||...                              ||......|..|...|
Zfish   414 DAMDDIVGDQNVICPLQHFAKSYAQYAALHAQSSAAAPGTLGWGNSGPTGYNSGNSHGAVYLYLF 478

  Fly   634 KHKTIEEEYPQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQST 698
            .|:.....:|:..|.:.|.::.|..|||:....  |||.:|.::.|.::||.:|||:|||||.:|
Zfish   479 DHRASNLAWPEWMGVIHGYEIEFVFGLPLEKRL--NYTAEEEKLSRRIMRYWANFARTGNPNVNT 541

Fly 699 698
Zfish 542 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	167/564 (30%)
ache	NP_571921.1	COesterase	23..583	CDD:278561	167/570 (29%)
ache	NP_571921.1	AChE_tetra	598..631	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910