Protein Alignment Nlg2 and CES1

DIOPT Version :9

• Sequence 1: NP_001245916.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 720
• Identity: 179/720 - (24%)
• Similarity: 279/720 - (38%)
• Gaps: 229/720 - (31%)

  Fly   149 SAVQPGHPEACALLVLLLLTSLWPDCCECLHGGSNTVKTKYGLLRGIVVRSSPLVEAFLGIPYAS 213
            ||...|||.:             |...:.:||   .|..|:..|.|.   :.| |..|||||:|.
Human    14 SAAWAGHPSS-------------PPVVDTVHG---KVLGKFVSLEGF---AQP-VAIFLGIPFAK 58

  Fly   214 PPVGSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQ 278
            ||:|.|||.||.....|..|::|..:.|:|.|:    |...:.|.|:    ....:..:||  ..
Human    59 PPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQD----PKAGQLLSEL----FTNRKENIPL--KL 113

  Fly   279 SEDCLYLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIV 343
            ||||||||||.|.:..:            |.:|..:|:|||......:.:.|||..||||.||:|
Human   114 SEDCLYLNIYTPADLTK------------KNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVV 166

  Fly   344 VTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANI 408
            |||.:||||:||..| |.|.::||:|.:|.||.|.|:::|:.:|||:|.|:|:.|...|....::
Human   167 VTIQYRLGIWGFFST-GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSV 230

  Fly   409 LVVSPVASDLIQRTVLVSGSALSPWAIQK---NPLFVKRRVAEQTGC----HGDMLYDDLAPCLR 466
            ||:||:|.:|..|.:..||.||:...::|   .||  ..::|...||    ...|::     |||
Human   231 LVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPL--AEQIAITAGCKTTTSAVMVH-----CLR 288

  Fly   467 TKSVAELLAVKV----------DHPRF---LVGFAPFVDGTVISPGANPLGST----TLPLGSAI 514
            .|:..|||...:          ..||.   |:|  ..:||.::......|.:.    |:|.
Human   289 QKTEEELLETTLKMKFLSLDLQGDPRESQPLLG--TVIDGMLLLKTPEELQAERNFHTVPY---- 347

  Fly   515 VSTSGIEYANF----PKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHL-- 573
              ..||....|    |.:.:.:.|:  |..||          .:|....:.::       |.|
Human   348 --MVGINKQEFGWLIPMQLMSYPLS--EGQLD----------QKTAMSLLWKS-------YPLVC 391

  Fly   574 --NEIFAVLKNEY---TDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHF 633
              .|:......:|   ||      :.:..:|..|..::|.....|.:.:...|...|...|...|
Human   392 IAKELIPEATEKYLGGTD------DTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEF 450

  Fly   634 ----------KHKTIEEEYPQRSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNF 688
                      |.||:..::.....||.|           :|......:.:|.::.::::::.:||
Human   451 QYRPSFSSDMKPKTVIGDHGDELFSVFG-----------APFLKEGASEEEIRLSKMVMKFWANF 504

  Fly   689 AKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSY 753
            |:.||||
Human   505 ARNGNPN---------------------------------------------------------- 511

  Fly   754 IRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQL--YVELGNKANIQSHYRGHKLS 816
                                       |:.||.|..|   ||.  |:::|.........:..:::
Human   512 ---------------------------GEGLPHWPEY---NQKEGYLQIGANTQAAQKLKDKEVA 546

  Fly   817 MWLNL 821
            .|.||
Human   547 FWTNL 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	159/574 (28%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	170/691 (25%)
		Aes	<122..>240	CDD:223730	53/130 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810