Protein Alignment Nlg2 and CEL

DIOPT Version :9

• Sequence 1: NP_001245916.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_001798.3
• Gene: CEL / 1056
• HGNCID: 1848
• Length: 753
• Species: Homo sapiens
• Alignment Length: 811
• Identity: 208/811 - (25%)
• Similarity: 304/811 - (37%)
• Gaps: 238/811 - (29%)

  Fly   162 LVLLLLTSLWPDCCECLHGGSNTVKTKYGLLRGIVVRSSPL---VEAFLGIPYASPPVGSLRFMP 223
            ||:|.||..|........|   .|.|:.|.:.|:..:...|   |:.|.|||:|:|   :.....
Human     6 LVVLGLTCCWAVASAAKLG---AVYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAP---TKALEN 64

  Fly   224 PITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIY 288
            |.....|:....|..|...|.|                 |.:.|....      ..||||||||:
Human    65 PQPHPGWQGTLKAKNFKKRCLQ-----------------ATITQDSTY------GDEDCLYLNIW 106

  Fly   289 VPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNP--------YDGSELAAHGNVIVVT 345
            ||...::..|:           |..:::|:|.::...||:.        |||.|:|..|||||||
Human   107 VPQGRKQVSRD-----------LPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVT 160

  Fly   346 INFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILV 410
            .|:|:|..|||.| |..:..||:||.|....:.|:|.|:.||||||.:|||.|...|....::..
Human   161 FNYRVGPLGFLST-GDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQT 224

  Fly   411 VSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCH-GDMLYDDLAPCLR-TKSVAEL 473
            :||....||:|.:..||.|||||.|||||||..::|||:.||. ||..  .:|.||: |...|..
Human   225 LSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDAA--RMAQCLKVTDPRALT 287

  Fly   474 LAVKV-----DHPRF-LVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIF 532
            ||.||     ::|.. .|||.|.:||..|.  |:|:..                |||....|.|.
Human   288 LAYKVPLAGLEYPMLHYVGFVPVIDGDFIP--ADPINL----------------YANAADIDYIA 334

  Fly   533 CLTSVESY----LDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLK---------NEY 584
            ...:::.:    :|:.|      .|:..:.      |.....|.|...|.:.|         :.|
Human   335 GTNNMDGHIFASIDMPA------INKGNKK------VTEEDFYKLVSEFTITKGLRGAKTTFDVY 387

  Fly   585 TD-WEKAIRNPL--SSRDATLQFLSDGHTASPL-IKLG-YMHSLRGGRAYFLHFKHKTIEEEYPQ 644
            |: |   .::|.  :.:...:.|.:|.....|. |.|. :..:.:..:.|...|.|.:....||:
Human   388 TESW---AQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPK 449

  Fly   645 RSGSVRGEDVPFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEV 709
            ..|:...:|:.:..|.|.:.  |..|..|:|.:.:.|:.|.:||||||:||.  ..|.:|
Human   450 WVGADHADDIQYVFGKPFAT--PTGYRPQDRTVSKAMIAYWTNFAKTGDPNM--GDSAVP----- 505

  Fly   710 LETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSER 774
                           ||
Human   506 ---------------TH------------------------------------------------ 507

  Fly   775 DVGSYDGDELPFWDAYDVVNQLYVELGNK---ANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSM 836
                        |:.|...|..|:|:..|   ::::...|.:.|..|......|.   .:.||
Human   508 ------------WEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALP---TVTDQ-- 555

  Fly   837 RHHQFQDDMNNRDLYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPSTNATQALNPLG-T 900
                           |....|     |..|..         .||.||:   ..:.|..:.|.| :
Human   556 ---------------EATPVP-----PTGDSE---------ATPVPPT---GDSETAPVPPTGDS 588

  Fly   901 GTPTTTECGIDGAMSVSELTTTQSPKDNRTG 931
            |.|.....|..||..|.....:.:|....||
Human   589 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	167/566 (30%)
CEL	NP_001798.3	Heparin-binding	21..121		33/139 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..753		21/99 (21%)
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745		19/78 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910