Protein Alignment Nlg2 and Ces2a

DIOPT Version :9

• Sequence 1: NP_001245916.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_598721.1
• Gene: Ces2a / 102022
• MGIID: 2142491
• Length: 558
• Species: Mus musculus
• Alignment Length: 622
• Identity: 176/622 - (28%)
• Similarity: 264/622 - (42%)
• Gaps: 152/622 - (24%)

  Fly   158 ACALLVLLLLTSLWPDCCECLHG---GSNTVKTKYGLLRGIVVR---SSPLVEAFLGIPYASPPV 216
            ||.||:||          :.:||   .|....|..|.:||..|.   :...|.||||||:|.|||
Mouse    14 ACGLLLLL----------QHVHGQDSASPIRNTHRGQVRGSFVHVKDTKSGVHAFLGIPFAKPPV 68

  Fly   217 GSLRFMPPITPSTWKTVRSADRFSPVCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSED 281
            |.|||.||..|..|..||.......:|.|        |: ::.:..|:  ::..:||.: :.|||
Mouse    69 GLLRFAPPEDPEPWSGVRDGTSQPAMCLQ--------PD-IMNLEDAK--EMNLILPPI-SMSED 121

  Fly   282 CLYLNIYVPYETRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTI 346
            |||||||.|            |..:..:.|..:|:|||......|.:..|.|:|||...:::|.|
Mouse   122 CLYLNIYTP------------THAQEGSNLPVMVWIHGGGLVVGSASMNDVSKLAATEEIVIVAI 174

  Fly   347 NFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVV 411
            .:|||:.||..| |.:.|:||:|.:|.||.|.|:::|:..|||:...:|:.|...|....:..::
Mouse   175 QYRLGVLGFFST-GDQHARGNWGYLDQVAALRWVQKNIAYFGGNRDRVTIFGVSAGGTSVSSHIL 238

  Fly   412 SPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHG-DMLYDDLAPCLRTKSVAELLA 475
            ||::..|....::.||.||.|..|......|.:.||..:||.. |.  :.|..|||.||..|:||
Mouse   239 SPMSKGLFHGAIMQSGVALLPDLISDTSEVVYKTVANLSGCEATDS--EALIHCLRAKSKQEILA 301

  Fly   476 VK---------VD------HPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANF 525
            :.         ||      ||:.|:....|          :|:.|        |:..:..|
Mouse   302 INQVFKMIPAVVDGEFLPKHPQELLTSMDF----------HPVPS--------IIGVNTDE---- 344

  Fly   526 PKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKN-------- 582
                   |...|..::.|              |.|::...|..       :.|||||
Mouse   345 -------CGWGVPMFMGL--------------DHIIKNITRET-------LPAVLKNTAARMMLP 381

  Fly   583 ---------EYT-DWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKT 637
                     ||. |.|    :|.:.:....:.|.|.....|.:::.:....: ...||..|:|.:
Mouse   382 PECSHLLVEEYMGDTE----DPETLQAQFREMLGDFMFVIPALQVAHFQRSQ-APVYFYEFQHLS 441

  Fly   638 --IEEEYPQRSGSVRGEDVPFWLGLPMSPLFPHN--YTTQERQIGRLMLRYLSNFAKTGNPNQST 698
              |:...|....:..|:||.|..|   |.|:..|  .|.:|..:.|:|::|.:|||:.||||...
Mouse   442 SFIKHVRPSHVKADHGDDVAFVFG---SYLWDMNLDLTEEEELLKRMMMKYWANFARNGNPNSEG 503

  Fly   699 AKS--VLPNPNEVLETALHQQKKRSTSLTHPNLSEAL 733
            ..|  ||.:..:.|:..           |.|.:..||
Mouse   504 LPSWPVLDHDEQYLQLD-----------TQPAVGRAL 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	164/572 (29%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:278561	168/596 (28%)
		Aes	<127..>230	CDD:223730	39/115 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810