DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg2 and nlgn4x

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	XP_017946613.1	Gene:	nlgn4x / 100329189	XenbaseID:	XB-GENE-6036018	Length:	833	Species:	Xenopus tropicalis

Alignment Length:	887	Identity:	267/887 - (30%)
Similarity:	399/887 - (44%)	Gaps:	217/887 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 CECLHGGSNTVKTKYGLLRGIVVRSSPL-------VEAFLGIPYASPPVGSLRFMPPITPSTWKT 232
            |:..|   ..|.|.||.:||   ..:||       ||.:||:||||||.|..||.||..||:|..
Frog    41 CQAQH---PIVPTNYGKIRG---TRTPLPIEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTG 99

  Fly   233 VRSADRFSPVCPQNIPIPPNGPEALLE--VPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYE--- 292
            :::|.:|:|||||.:     ...:||.  :|....|.|..::..:::|:|||||||||||.|
Frog   100 IKNATQFAPVCPQFL-----DERSLLNDMLPIWFTANLDTVVSYVQDQNEDCLYLNIYVPTEDGA 159

  Fly   293 -TRRQR-------RNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFR 349
             |::|.       |..|:...:|..|...:|:|||.||...:||..|||.||:||||||:|:|:|
Frog   160 TTKKQADDIANNDRGEDEDIHDPNNKKPVMVYIHGGSYMEGTGNMIDGSILASHGNVIVITVNYR 224

  Fly   350 LGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPV 414
            ||:.|||.| |.::|:||:||:|.:..|.|::||:.||||||:.:|:.|.|.||...::|.:|..
Frog   225 LGVLGFLST-GDQAAKGNYGLLDQIQALRWIEENIGAFGGDPKRVTIFGSGAGASCVSLLTLSHY 288

  Fly   415 ASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYD-DLAPCLRTKSVAELLAVKV 478
            :..|.|:.::.||:|||.||:...|....|.:|::.||  |||.. ||..|||.|:..||:...:
Frog   289 SEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGC--DMLDTIDLVECLRDKNYKELIQQSI 351

  Fly   479 DHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVE--SYL 541
            ....:.:.|.|.:||.||            |....|:...| |:.|:   |::..:...|  .::
Frog   352 TPATYHIAFGPVIDGDVI------------PDDPQILMEQG-EFLNY---DIMLGVNQGEGLKFV 400

  Fly   542 DLSAQDLEFGFNETRRDRILRTFVRNNFHY-----HLNEIFAVLKNEYTDWEKAIRNPLSSRDAT 601
            | ...|.|.|.:.:..|..:..||.|.:.|     .|.|   .:|..||||... .||.:.|...
Frog   401 D-GMVDNEDGVSLSDFDFSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDWADK-ENPETRRKTL 460

  Fly   602 LQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPM---S 663
            :...:|....:|.:....:|:..|...||..|.|....|..|..:.|..|::||:..|:||   :
Frog   461 VALFTDHQWVAPAVATADLHARYGSPTYFYAFYHHCQSEMKPTWADSAHGDEVPYVFGIPMIGPT 525

  Fly   664 PLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPN 728
            .||..|::..:..:..:::.|.:||||||:||:       |.|.:.  ..:|         |.||
Frog   526 ELFNCNFSKNDVMLSAVVMTYWTNFAKTGDPNK-------PVPQDT--KFIH---------TKPN 572

  Fly   729 LSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVV 793
                                          |..:.|                      |..||..
Frog   573 ------------------------------RFEEVA----------------------WSKYDPK 585

  Fly   794 NQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQ 858
            :|||:.:|.|..::.|||..|::.||.|:|.||   |:|:
Frog   586 DQLYLHIGLKPRVRDHYRATKVAFWLELVPHLH---NLNE------------------------- 622

  Fly   859 LQTKPAEDDNIIIMQRSRTTTPPPP--SKNPSTNATQALNP-LGTGTPTTTECGIDGAMSVSELT 920
                       |....|.||..|||  :..|.......|.| :.|..|..|
Frog   623 -----------IFQYVSTTTKVPPPDMTSYPHVTRRPPLKPRITTKRPAMT-------------- 662

  Fly   921 TTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNV 985
                |.:|..     ||||::...:|.|.           :..:.|:|.|..|:|||..||.||:
Frog   663 ----PANNAK-----ETQKNVLGENTIIT-----------EDKRDYSTELSVTIAVGASLLFLNI 707

  Fly   986 LIFAGIYHQREKRARDAKTKEELQEGDNS-----KNSSILKL 1022
            |.||.:|::::||..:...:...|....:     :|..|:.|
Frog   708 LAFAALYYKKDKRRHETHRRPSPQRNTTNDIAHIQNEEIMSL 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	197/560 (35%)
nlgn4x	XP_017946613.1	COesterase	46..610	CDD:365897	215/665 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	367	1.000	Domainoid score	I918
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H84460
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9495
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.050