DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg2 and nlgn3

DIOPT Version :9

Sequence 1:	NP_001245916.1	Gene:	Nlg2 / 33962	FlyBaseID:	FBgn0031866	Length:	1248	Species:	Drosophila melanogaster
Sequence 2:	XP_012823589.1	Gene:	nlgn3 / 100329188	XenbaseID:	XB-GENE-977261	Length:	843	Species:	Xenopus tropicalis

Alignment Length:	933	Identity:	272/933 - (29%)
Similarity:	403/933 - (43%)	Gaps:	273/933 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 SNTVKTKYGLLRGIVVRSSPL-------VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRF 239
            |.||.|.||.|||..|   ||       |:.:||:|||:||||..||:||..|.:|..:|:|..|
Frog    35 SQTVNTHYGKLRGTRV---PLPSEILGPVDQYLGVPYAAPPVGEKRFLPPEPPPSWSGIRNATHF 96

  Fly   240 SPVCPQNI--PIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDD 302
            ||||||||  .:|.      :.:|....:.|..:...|:.|||||||||||||  |...:|.:.:
Frog    97 SPVCPQNIQNAVPD------IMMPVWFTSNLDTVTGYLQEQSEDCLYLNIYVP--TEDVKRISKE 153

  Fly   303 TTGEPKTKL--------------------------------STVVFIHGESYDWNSGNPYDGSEL 335
            ...:|..|:                                ..:|:|||.||...|||..|||.|
Frog   154 CVRKPNKKICRKGGPSAKKQGEELSDNDEDEEGDIRDTGAKPVMVYIHGGSYMEGSGNMIDGSVL 218

  Fly   336 AAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYG 400
            |::|||:|:|:|:|:|:.|||.| |.::|:||:||:|.:..|.|:.||:..|||||..||:.|.|
Frog   219 ASYGNVVVITLNYRVGVLGFLST-GDQAAKGNYGLLDQIQALRWVSENVAFFGGDPHRITVFGSG 282

  Fly   401 TGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYD--DLAP 463
            .||...::|.:|..:..|.||.::.||||||.||:...|:...|.:||:.||:   :.|  |:..
Frog   283 IGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTRLLAEKVGCN---VLDTVDMVD 344

  Fly   464 CLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKR 528
            |||.||..||:...:...|:.|.|.|.:||.||            |....|:...| |:.|:
Frog   345 CLRQKSAKELVEQDIQPARYHVAFGPVIDGDVI------------PDDPEILMEQG-EFLNY--- 393

  Fly   529 DLIF------CLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHY-----HLNEIFAVLKN 582
            |::.      .|..||:.:|  |:|   |.:.:..|..:..||.|.:.|     .|.|   .:|.
Frog   394 DIMLGVNQGEGLKFVENVVD--AED---GVSGSDFDYSVSNFVDNLYGYPEGKDTLRE---TIKF 450

  Fly   583 EYTDWEKAIR-NPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRS 646
            .||||  |.| ||.:.|...:...:|.....|.:....:|:..|...||..|.|.......|..:
Frog   451 MYTDW--ADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWA 513

  Fly   647 GSVRGEDVPFWLGLPM---SPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNE 708
            .:..|::||:..|:||   :.|||.|::..:..:..:::.|.:||||||:||:       |.|.:
Frog   514 DAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNK-------PVPQD 571

  Fly   709 VLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSE 773
                                               :..:|.|.:      |..:.|
Frog   572 -----------------------------------TKFIHTKAN------RFEEVA--------- 586

  Fly   774 RDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRH 838
                         |..|:..:|||:.:|.|..::.|||..|::.|.:|:|.|   :|::|  |.|
Frog   587 -------------WSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHL---YNLHD--MFH 633

  Fly   839 HQFQDDMNNRDLYEGVVRPQLQTK-PAED--DNIIIMQRSRTTTPPPPSKNPSTNATQA-----L 895
            :                 ....|| |..|  .|..|.:|.:......|..:|:.|...|     |
Frog   634 Y-----------------TSTTTKVPPSDTTQNSHITRRPKVWDTKRPGVSPTFNGPVAKWDPEL 681

  Fly   896 NPLGTGTPTTTECGIDGAMSVSELTTTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGG 960
            :|:                   :....|.|:|
Frog   682 DPV-------------------DPVVIQDPRD--------------------------------- 694

  Fly   961 KQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQREKRARD----------AKTKEELQEGDNSK 1015
                 |:|.|..|:|||..||.||||.||.:|::.:||.:|          |.|::........:
Frog   695 -----YSTELSVTIAVGASLLFLNVLAFAALYYRNDKRRQDTQRQPSPQRPAVTRDPAHSPVPPE 754

  Fly  1016 NSSILKLNALMG-----GGGACG 1033
            ..:.|::||  |     |||..|
Frog   755 ELNSLQINA--GHPECEGGGVSG 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	204/587 (35%)
nlgn3	XP_012823589.1	COesterase	31..618	CDD:278561	219/693 (32%)
nlgn3	XP_012823589.1	Aes	<195..>302	CDD:223730	51/107 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	367	1.000	Domainoid score	I918
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9495
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.050