Protein Alignment Nlg2 and nlgn4xb

DIOPT Version :10

• Sequence 1: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Sequence 2: NP_001159809.1
• Gene: nlgn4xb / 100147967
• ZFINID: ZDB-GENE-100309-1
• Length: 795
• Species: Danio rerio
• Alignment Length: 847
• Identity: 252/847 - (29%)
• Similarity: 382/847 - (45%)
• Gaps: 209/847 - (24%)

  Fly   184 TVKTKYGLLRGI-VVRSSPL---VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPVCP 244
            ||.|.||.|||: |...|.:   ||.|||:|||..|.|..||..|..|.:|..:|:|.:|:||||
Zfish    24 TVTTNYGKLRGLRVALPSEILGPVEQFLGVPYAMAPTGERRFQAPEPPLSWPGIRNATQFAPVCP 88

  Fly   245 QNIPIPPNGPEALL---EVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGE 306
            |.:      .:.||   .:|....|.|..:...:.:|||||||||||||.|...|    ||...:
Zfish    89 QFL------EDRLLLTDMLPVWFTANLDTVATYVHDQSEDCLYLNIYVPTEEETQ----DDAGLK 143

  Fly   307 PKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFGLM 371
            |     .:|:|||.||...:||..|||.||::|||||||:|:|||:.|||.| |.::|:||:||:
Zfish   144 P-----VMVYIHGGSYVEGTGNMIDGSVLASYGNVIVVTVNYRLGVLGFLST-GDQAAKGNYGLL 202

  Fly   372 DLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWAIQ 436
            |.:..|.|:|||:.:|.|||:.:|:.|.|.||...::|.:|..:.||.|:.::.||:|||.||:.
Zfish   203 DQIQALRWVKENIQSFSGDPERVTIFGSGAGASCVSLLTLSHYSEDLFQKAIIHSGTALSSWAVN 267

  Fly   437 KNPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKSVAELLAVKVDHPRFLVGFAPFVDGTVISPGAN 501
            ..|....|.:||:.||:.|... :|..||::|:..||:...:...::.:.|.|.:||.||
Zfish   268 YQPAKYTRLLAEKVGCNEDDTL-ELIECLQSKNYKELIEQNITPAKYHIAFGPVIDGDVI----- 326

  Fly   502 PLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCLTSVESY------LD----LSAQDLEFGFNETR 556
                   |....|:...| |:.|:   |::..:...|.|      ||    :::.|.||..:|
Zfish   327 -------PDDPQILMEQG-EFLNY---DIMLGVNQGEGYKFVDGILDSEDRVTSNDFEFAISE-- 378

  Fly   557 RDRILRTFVRNNFHY-----HLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIK 616
                   ||.:.:.|     .|.|   .:|..||||... .||...|...:...:|....:|.:.
Zfish   379 -------FVDHLYGYPEGKDTLRE---TIKFMYTDWADR-ENPEMRRKTLVALFTDHQWVAPAVA 432

  Fly   617 LGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPFWLGLPM---SPLFPHNYTTQERQIG 678
            ...:|:..|...||..|.|....:..|..:.|..|:::|:..|:||   :.||..|::..:..:.
Zfish   433 TADLHAQYGSPTYFYAFYHHCQSDMKPAWADSSHGDELPYVFGIPMIGPTDLFNCNFSKNDIMLS 497

  Fly   679 RLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRR 743
            .:::.|.:||||||:|||       |.|.:.  ..:|         |.||
Zfish   498 AVVMTYWTNFAKTGDPNQ-------PVPQDT--KFIH---------TKPN--------------- 529

  Fly   744 SNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQS 808
                           |..:.|                      |..|:..:|||:.:|.|..::.
Zfish   530 ---------------RFEEVA----------------------WSKYNPKDQLYLHIGLKPRVRD 557

  Fly   809 HYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTKPAEDDNIIIMQ 873
            |||..|::.||.|:|.||   |||                :|::.|
Zfish   558 HYRATKIAFWLELVPHLH---NIN----------------ELFQYV------------------- 584

  Fly   874 RSRTTTPPPPSKNPSTNATQALNPLGTGTPTTTECGIDGAMSVSELTTTQSPKDNRTGIVRVETQ 938
             |.||..||....|.:...:..|.|   .|:||........:..:::..|...::..|.|.:|.
Zfish   585 -SSTTKIPPQDTTPFSYTKRLSNKL---FPSTTRHPPAPPANTKQMSDQQKTSEHADGTVIIEA- 644

  Fly   939 KDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGCFLLILNVLIFAGIYHQREKRARDAK 1003
                                     :.|:|.|..|:|||..||.||:|.||.:|::::|...::.
Zfish   645 -------------------------RDYSTELSVTIAVGASLLFLNILAFAALYYKKDKHRLESS 684

  Fly  1004 TK 1005
            .:
Zfish   685 RR 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	196/569 (34%)
nlgn4xb	NP_001159809.1	COesterase	24..567	CDD:395084	210/658 (32%)